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Michael Spencer Chapman
Researcher at Wellcome Trust Sanger Institute
Publications - 21
Citations - 1242
Michael Spencer Chapman is an academic researcher from Wellcome Trust Sanger Institute. The author has contributed to research in topics: Biology & Haematopoiesis. The author has an hindex of 7, co-authored 15 publications receiving 176 citations. Previous affiliations of Michael Spencer Chapman include Cambridge University Hospitals NHS Foundation Trust & Imperial College Healthcare.
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Journal ArticleDOI
Hospital admission and emergency care attendance risk for SARS-CoV-2 delta (B.1.617.2) compared with alpha (B.1.1.7) variants of concern: a cohort study.
Katherine A Twohig,Tommy Nyberg,Asad Zaidi,Simon Thelwall,Mary Sinnathamby,Shirin Aliabadi,Shaun R. Seaman,Ross J Harris,Russell Hope,Jamie Lopez-Bernal,Eileen Gallagher,Andre Charlett,Daniela De Angelis,Daniela De Angelis,Anne M. Presanis,Anne M. Presanis,Gavin Dabrera,Cherian Koshy,Amy Ash,Emma L. Wise,Nathan Moore,Matilde Mori,Nick Cortes,Jessica Lynch,Stephen P. Kidd,Derek Fairley,Tanya Curran,James McKenna,Helen Adams,Christophe Fraser,Tanya Golubchik,David Bonsall,Mohammed O Hassan-Ibrahim,Cassandra S Malone,Benjamin J Cogger,Michelle Wantoch,Nicola Reynolds,Ben Warne,Joshua Maksimovic,Karla Spellman,Kathryn McCluggage,Michaela John,Robert Beer,Safiah Afifi,Sian Morgan,Angela Marchbank,Anna Price,Christine Kitchen,Huw Gulliver,Ian Merrick,Joel Southgate,Martyn Guest,Robert J. Munn,Trudy Workman,Thomas R. Connor,William D. Fuller,Catherine Bresner,Luke B Snell,Amita Patel,Themoula Charalampous,Gaia Nebbia,Rahul Batra,Jonathan D. Edgeworth,Samuel Robson,Angela Helen Beckett,David M. Aanensen,Anthony Underwood,Corin Yeats,Khalil Abudahab,Ben Taylor,Mirko Menegazzo,Gemma Clark,Wendy Smith,Manjinder Khakh,Vicki M. Fleming,Michelle Lister,Hannah C. Howson-Wells,Louise Berry,Tim Boswell,Amelia Joseph,Iona Willingham,Carl Jones,Christopher W Holmes,Paul W Bird,Thomas Helmer,Karlie Fallon,Julian Tang,Veena Raviprakash,Sharon Campbell,Nicola Sheriff,Victoria Blakey,Lesley-Anne Williams,Matthew Loose,Nadine Holmes,Christopher I. Moore,Matthew Carlile,Victoria Wright,Fei Sang,Johnny Debebe,Francesc Coll,Adrian W Signell,Gilberto Betancor,Harry D Wilson,Sahar Eldirdiri,Anita Kenyon,Thomas R. A. Davis,Oliver G. Pybus,Louis du Plessis,Alex Zarebski,Jayna Raghwani,Moritz U. G. Kraemer,Sarah François,Stephen W Attwood,Tetyana I. Vasylyeva,Marina Escalera Zamudio,Bernardo Gutierrez,M. Estée Török,William L Hamilton,Ian Goodfellow,Grant Hall,Aminu S Jahun,Yasmin Chaudhry,Myra Hosmillo,Malte L Pinckert,Iliana Georgana,S.E. Moses,Hannah Lowe,Luke Bedford,Jonathan D. Moore,Susanne Stonehouse,Chloe L Fisher,Ali R Awan,John Boyes,Judith Breuer,Kathryn Ann Harris,Julianne R Brown,Divya K. Shah,Laura Atkinson,Jack Cd Lee,Nathaniel Storey,Flavia Flaviani,Adela Alcolea-Medina,Rebecca Williams,Gabrielle Vernet,Michael A Chapman,Lisa J Levett,Judith Heaney,Wendy Chatterton,Monika Pusok,Li Xu-McCrae,Darren Smith,Matthew Bashton,Gregory R Young,Alison Holmes,Paul Randell,Alison Cox,Pinglawathee Madona,Frances Bolt,James I. Price,Siddharth Mookerjee,Manon Ragonnet-Cronin,Fabrícia F. Nascimento,David Jorgensen,Igor Siveroni,Robert Johnson,Olivia Boyd,Lily Geidelberg,Erik M. Volz,Aileen G. Rowan,Graham P. Taylor,Katherine Smollett,Nicholas J. Loman,Joshua Quick,Claire McMurray,Joanne D. Stockton,Samuel M. Nicholls,Will P. M. Rowe,Radoslaw Poplawski,Alan McNally,Rocio Martinez Nunez,Jenifer Mason,Trevor Robinson,Elaine O'Toole,Joanne Watts,Cassie Breen,Angela Cowell,Graciela Sluga,Nicholas W Machin,Shazaad Ahmad,Ryan P George,Fenella D. Halstead,Venkat Sivaprakasam,Wendy Hogsden,Christopher J. R. Illingworth,Christopher Jackson,E. Thomson,James Shepherd,Patawee Asamaphan,Marc Niebel,Kathy Li,Rajiv Shah,Natasha Jesudason,Lily Tong,Alice Broos,Daniel Mair,Jenna Nichols,Stephen Carmichael,Kyriaki Nomikou,Elihu Aranday-Cortes,Natasha Johnson,Igor Starinskij,Ana da Silva Filipe,David Robertson,Richard J. Orton,Joseph Hughes,Sreenu Vattipally,Joshua B Singer,Seema Nickbakhsh,Antony D Hale,Louissa R Macfarlane-Smith,Katherine L Harper,Holli Carden,Yusri Taha,Brendan A I Payne,Shirelle Burton-Fanning,Sheila Waugh,Jennifer Collins,Gary Eltringham,Steven Rushton,Sarah J. O'Brien,Amanda Bradley,Alasdair MacLean,Guy Mollett,Rachel Blacow,Kate Templeton,Martin P McHugh,Rebecca Dewar,Elizabeth Wastenge,Samir Dervisevic,Rachael Stanley,Emma Meader,Lindsay Coupland,Louise Smith,Clive Graham,Edward Barton,Debra Padgett,Garren Scott,Emma Swindells,Jane Greenaway,Andrew J. Nelson,Clare M. McCann,Wen Yew,Monique Andersson,Tim E. A. Peto,Anita Justice,David W Eyre,Derrick W. Crook,Tim J Sloan,Nichola Duckworth,Sarah Walsh,Anoop Chauhan,Sharon Glaysher,Kelly Bicknell,Sarah Wyllie,Scott Elliott,A Lloyd,Robert Impey,Nick Levene,Lynn Monaghan,Declan Bradley,Tim Wyatt,Elias Allara,Clare Pearson,Husam Osman,Andrew Bosworth,Esther Robinson,Peter Muir,Ian B Vipond,Richard Hopes,Hannah M Pymont,Stephanie Hutchings,Martin D. Curran,Surendra Parmar,Angie Lackenby,Tamyo Mbisa,Steven Platt,Shahjahan Miah,David F. Bibby,Carmen F. Manso,Jonathan Hubb,Meera Chand,Mary Ramsay,Daniel Bradshaw,Alicia Thornton,Richard H. Myers,Ulf Schaefer,Natalie Groves,David C. Lee,David J. Williams,Nicholas Ellaby,Ian Harrison,Hassan Hartman,Nikos Manesis,Vineet Patel,Chloe Bishop,Vicki Chalker,Juan Ledesma,Katherine Twohig,Matthew T. G. Holden,Sharif Shaaban,Alec Birchley,Alexander Adams,Alisha Davies,Amy Gaskin,Amy Plimmer,Bree Gatica-Wilcox,Caoimhe McKerr,Catherine Moore,Christopher Williams,David Heyburn,Elen De Lacy,Ember Hilvers,Fatima Downing,Giri Shankar,Hannah Jones,Hibo Asad,Jason Coombes,Joanne Watkins,Johnathan M Evans,Laia Fina,Laura Gifford,Lauren Gilbert,Lee Graham,Malorie Perry,M Morgan,Matthew J. Bull,Michelle Cronin,Nicole Pacchiarini,Noel Craine,Rachel Jones,Robin Howe,Sally Corden,Sara Rey,Sara Kumziene-Summerhayes,S Taylor,Simon Cottrell,Sophie Jones,Sue Edwards,Justin O'Grady,Andrew J. Page,Alison E. Mather,David Baker,Steven Rudder,Alp Aydin,Gemma L. Kay,Alexander J. Trotter,Nabil-Fareed Alikhan,Leonardo de Oliveira Martins,Thanh Le-Viet,Lizzie Meadows,Anna L. Casey,Liz Ratcliffe,David Simpson,Zoltan Molnar,Thomas Thompson,Erwan Acheson,Jane A. H. Masoli,Bridget Knight,Sian Ellard,Cressida Auckland,Christopher I. Jones,Tabitha Mahungu,Dianne Irish-Tavares,Tanzina Haque,Jennifer Hart,Eric Witele,Melisa Louise Fenton,Ashok Dadrah,Amanda Symmonds,Tranprit Saluja,Yann Bourgeois,Garry Scarlett,Katie F. Loveson,Salman Goudarzi,Christopher Fearn,Kate B. Cook,Hannah Dent,Hannah Paul,David G Partridge,Mohammad Raza,Cariad Evans,Kate Johnson,Steven Liggett,Paul Baker,Stephen Bonner,Sarah Essex,Ronan Lyons,Kordo Saeed,Adhyana I K Mahanama,Buddhini Samaraweera,Siona Silveira,Emanuela Pelosi,Eleri Wilson-Davies,Rachel Williams,Mark Kristiansen,Sunando Roy,Charlotte A Williams,Marius Cotic,Nadua Bayzid,Adam P Westhorpe,John C. Hartley,Riaz Jannoo,Helen L Lowe,Angeliki Karamani,Leah Ensell,Jacqui Prieto,Sarah Jeremiah,Dimitris Grammatopoulos,Sarojini Pandey,Lisa Berry,Katie Jones,Alex G. Richter,Andrew D Beggs,Angus I. Best,Benita Percival,Jeremy Mirza,Oliver Megram,Megan Mayhew,Liam Crawford,Fiona Ashcroft,Emma Moles-Garcia,Nicola Cumley,Colin Smith,Giselda Bucca,Andrew Hesketh,Beth Blane,Sophia T Girgis,Danielle Leek,Sushmita Sridhar,Sally Forrest,Claire Cormie,Harmeet K Gill,Joana Dias,Ellen Higginson,Mailis Maes,Jamie Young,Leanne M Kermack,Ravi Gupta,Catherine Ludden,Sharon J. Peacock,Sophie Palmer,Carol Churcher,Nazreen F. Hadjirin,Alessandro M Carabelli,Ellena Brooks,Kim S Smith,Katerina Galai,Georgina M McManus,Christopher Ruis,Rose K Davidson,Andrew Rambaut,Thomas N. Williams,Carlos Balcazar,Michael Gallagher,Áine O'Toole,Stefan Rooke,Verity Hill,Kathleen A. Williamson,Thomas D Stanton,Stephen L. Michell,Claire M Bewshea,Ben Temperton,Michelle L Michelsen,Joanna Warwick-Dugdale,Robin Manley,Audrey Farbos,James W. Harrison,Christine Sambles,David J. Studholme,Aaron R. Jeffries,Leigh M Jackson,Alistair C. Darby,Julian A. Hiscox,Steve Paterson,Miren Iturriza-Gomara,Kathryn A Jackson,Anita Lucaci,Edith Vamos,Margaret Hughes,Lucille Rainbow,Richard Eccles,Charlotte Nelson,Mark Whitehead,Lance Turtle,Sam Haldenby,Richard Gregory,Matthew Gemmell,Claudia Wierzbicki,Hermione J. Webster,Thushan I de Silva,Nikki Smith,Adrienn Angyal,Benjamin B Lindsey,Danielle C. Groves,Luke R. Green,Dennis Wang,Timothy M. Freeman,Matthew Parker,Alexander J Keeley,Paul J. Parsons,Rachel Tucker,Rebecca C H Brown,Matthew Wyles,Max Whiteley,Peijun Zhang,Marta Gallis,Stavroula F Louka,Chrystala Constantinidou,Meera Unnikrishnan,Sascha Ott,Jeffrey K. J. Cheng,Hannah E Bridgewater,Lucy R. Frost,Grace Taylor-Joyce,Richard Stark,Laura Baxter,Mohammad Tauqeer Alam,Paul E Brown,Dinesh Aggarwal,Alberto C Cerda,Tammy V Merrill,Rebekah E Wilson,Patrick McClure,Joseph G. Chappell,Theocharis Tsoleridis,Jonathan K. Ball,David Buck,John A. Todd,Angie Green,Amy Trebes,G MacIntyre-Cockett,Mariateresa de Cesare,Alex Alderton,Roberto Amato,Cristina V. Ariani,Mathew A. Beale,Charlotte Beaver,Katherine L. Bellis,Emma Betteridge,James Bonfield,John Danesh,Matthew J. Dorman,Eleanor Drury,Ben Farr,Luke Foulser,Sónia Gonçalves,Scott Goodwin,Marina Gourtovaia,Ewan M. Harrison,David A. Jackson,Dorota Jamrozy,Ian Johnston,Leanne Kane,Sally Kay,Jon-Paul Keatley,Dominic P. Kwiatkowski,Cordelia Langford,Mara K. N. Lawniczak,Laura Letchford,Rich Livett,Stephanie W. Lo,Inigo Martincorena,Samantha McGuigan,Rachel Nelson,Steve Palmer,Naomi Park,Minal Patel,Liam Prestwood,Christoph Puethe,Michael A. Quail,Shavanthi Rajatileka,Carol Scott,Lesley Shirley,John Sillitoe,Michael Spencer Chapman,Scott Aj Thurston,Gerry Tonkin-Hill,Danni Weldon,Diana Rajan,Iraad Bronner,Louise Aigrain,Nicholas M Redshaw,Stefanie V Lensing,Robert Davies,Andrew Whitwham,Jennifier Liddle,Kevin Lewis,Jaime Tovar-Corona,Steven Leonard,Jillian Durham,Andrew Bassett,Shane McCarthy,Robin J Moll,Keith D. James,Karen Oliver,Alex Makunin,Jeffrey C. Barrett,Rory Gunson +607 more
TL;DR: In this paper, the authors compared the severity of the delta variant compared with the alpha variant by determining the relative risk of hospital attendance outcomes and found that outbreaks of the Delta variant in unvaccinated populations might lead to a greater burden on health-care services than the alpha variants.
Journal ArticleDOI
SARS-CoV-2 Omicron is an immune escape variant with an altered cell entry pathway
Brian J. Willett,Joe Grove,Oscar A. MacLean,Craig Wilkie,Giuditta De Lorenzo,Wilhelm Furnon,Diego Cantoni,S. Scott,Nicola S Logan,Shirin Ashraf,M. Manali,Agnieszka M. Szemiel,Vanessa M. Cowton,Elen Vink,Chris Davis,Patawee Asamaphan,Richard J. Orton,P Holland,Vanessa Silva,David J Pascall,Kathryn Puxty,Sharif Shaaban Muhammad Shaaban,Matthew T. G. Holden,Rute Maria Pinto,Kate Templeton,Pablo R. Murcia,Arvind H. Patel,Paul Klenerman,Susanna Dunachie,Eleanor Barnes,Anthony Brown,S Adele,Barbara Kronsteiner,Sam M. Murray,P. Abraham,Alexandra Deeks,M A Ansari,Lance Turtle,Shona C Moore,James Austin,Alex G. Richter,Christopher J A Duncan,Rebecca Payne,Amy Ehrlich Ash,C. J. Koshy,Beatrix Kele,Teresa Cutino-Moguel,Derek Fairley,James McKenna,Tanya Curran,Helen Adams,Christophe Fraser,David Bonsall,Helen R. Fryer,Katrina A. Lythgoe,Laura Hayden Thomson,Tanya Golubchik,Abigail Murray,D. Singleton,Shaun M. Beckwith,A Mantzouratou,Magdalena Barrow,Sarah L. Buchan,Nicola Reynolds,Ben Warne,Joshua Maksimovic,Karla Spellman,Kathryn Mccluggage,M. John,Robert H. Beer,Safiah Afifi,Sian Natasha Morgan,Andrew L. Mack,Angela Marchbank,Anna Price,A.C. Morriss,Catherine Bresner,Christine Kitchen,I. Merrick,Joel Southgate,Martyn F Guest,Owen Bowden Jones,Robert F. Munn,Thomas R. Connor,Tom Whalley,T. Race Workman,William Oliver Fuller,Amita Patel,Bindi Patel,G. Nebbia,Jonathan D. Edgeworth,Luke B Snell,Rahul Batra,Themoula Charalampous,Angela Helen Beckett,Ekaterina Shelest,Samuel Robson,Anthony Underwood,Benjamin Taylor,Corin Yeats,David M. Aanensen,Khalil Abudahab,Mirko Menegazzo,Amelia Joseph,Gemma Clark,Hannah C. Howson-Wells,Louise Berry,Manjinder Khakh,Michelle Lister,T. Boswell,Vicki M. Fleming,Christopher W Holmes,Claire McMurray,Jessica R. Shaw,Julian W. Tang,Karlie Fallon,Minaxshi Odedra,Nicholas J. Willford,Paul W Bird,Thomas Helmer,L.A. Williams,Nicole R. Sheriff,Sharon Campbell,Veena Raviprakash,Vickie L. Blakey,Christopher I. Moore,Fei Sang,Johnny Debebe,Matthew Carlile,Matthew Loose,Nadine Holmes,Victoria Wright,M. Torok,William L Hamilton,Alessandro M Carabelli,Andrew Jermy,Beth Blane,Carol Churcher,Catherine Ludden,Dinesh Aggarwal,Elaine J. Westwick,Ellen Brigid Brooks,Georgina M. McManus,Katerina Galai,Ken R. Smith,Kim Smith,MacGregor Cox,Mireille Fragakis,Patrick Maxwell,Sarah Judges,Sharon J. Peacock,Theresa Feltwell,A. K. Kenyon,Sahar Eldirdiri,Thomas Davis,Joshua F. Taylor,NgeeKeong Tan,Alexander E. Zarebski,Bernardo Gutierrez,Jayna Raghwani,Louis du Plessis,Moritz U. G. Kraemer,Oliver G. Pybus,Sarah François,S. W. Attwood,Tetyana I. Vasylyeva,Aminu S Jahun,Ian Goodfellow,Iliana Georgana,Malte L Pinckert,Myra Hosmillo,Rhys E. Izuagbe,Yasmin Chaudhry,Felicity Ryan,Hannah Louise Lowe,Samuel Rajan Moses,Luke Bedford,James S Cargill,Warwick S. Hughes,J. Moore,Susanne Stonehouse,Divya Shah,Jack Lee,Julianne R Brown,Kathryn A. Harris,Laura Atkinson,Nathaniel Storey,Moira J. Spyer,Flavia Flaviani,Adela Alcolea-Medina,J. Sehmi,John Ramble,Natasha Ohemeng-Kumi,P. Smith,B. Bertolusso,Claire P Thomas,Gabrielle Vernet,Jessica Lynch,Nathan Moore,Nicholas Cortes,Rebecca Williams,Stephen P. Kidd,L. J. Levett,Monika Pusok,Paul Grant,Stuart Kirk,W. J. Chatterton,Li Xu-McCrae,Darren L. Smith,Gregor Young,Matthew Bashton,Katie Kitchman,Kavitha Gajee,K. Eastick,Patrick J. Lillie,Phillipa Burns,William G. Everson,Alison Cox,Alison Holmes,Frances Bolt,James R. Price,Marcus Pond,Paul Randell,Pinglawathee Madona,Siddharth Mookerjee,Erik M. Volz,Lily Geidelberg,Manon Ragonnet-Cronin,Olivia Boyd,Robert Johnson,Cassie F Pope,Adam A. Witney,Irene M. Monahan,Ken Laing,Katherine Smollett,Alan McNally,Joanne Stockton,Joshua Quick,Nicholas J. Loman,Radoslaw Poplawski,Samuel M. Nicholls,Will P. M. Rowe,Anibolina Castigador,Emily Macnaughton,Kate El Bouzidi,Malur Sudhanva,Temi Lampejo,Rocio Martinez Nunez,Cathy Breen,Graciela Sluga,Karen T. Withell,Nicholas W Machin,Ryan George,Shazaad Ahmad,David Pritchard,D. Binns,Nick Wong,Victoria L. James,Cheryl Williams,Christopher J. R. Illingworth,Christopher Jackson,Daniela De Angelis,Afrida Mukaddas,Alice Broos,Ana da Silva Filipe,Daniel Mair,David Robertson,Derek W. Wright,E. Thomson,Igor Starinskij,Ioulia Tsatsani,James Shepherd,Jenna Nichols,Joseph Hughes,Kyriaki Nomikou,Lily Tong,Sreenu B. Vattipally,William T. Harvey,Roy A. Sanderson,S. O’Brien,Steven Rushton,Jon Davis Perkins,Rachel Blacow,Rory Gunson,A. Gallagher,Elizabeth Wastnedge,Martin P McHugh,Rebecca Dewar,Seb Cotton,Lindsay Coupland,R.Suganya and Dr. Shaleesha A. Stanley,Samir Dervisevic,Lewis G. Spurgin,Louise Smith,Clive Graham,D. Padgett,Edward Barton,Garren Scott,Aidan Cross,Mariyam Mirfenderesky,E. Swindells,J Greenaway,Rebecca Denton-Smith,Robyn Turnbull,Giles Idle,Kevin Cole,Amy Louise Hollis,Andrew T. Nelson,C. McCann,Joan H Henderson,M. Crown,Wen Chyin Yew,W Stawski Stanley,Nicholas Duckworth,Phillip Clarke,Sarah Walsh,Tim J. Sloan,Kelly Bicknell,R. L. Impey,Sarah Wyllie,Scott M. Elliott,Sharon Glaysher,Declan Bradley,Nicholas Killough,Tim W. Wyatt,Andrew Bosworth,Barry Vipond,Clare Pearson,Elias Allara,E. E Robinson,Hannah M. Pymont,Husam Osman,Peter C. Muir,Richard Hopes,S. A. Hutchings,Martin D. Curran,Surendra S. Parmar,A Thornton,Angie Lackenby,Chloe Bishop,David F. Bibby,Dave Lee,Eileen Gallagher,Gavin Dabrera,Ian Harrison,Jonathan Hubb,Katherine A. Twohig,Meera Chand,Nicholas Ellaby,Nikos Manesis,R. Myers,Steven Platt,Tamyo Mbisa,Vicki Chalker,Gonzalo Yebra,Stefan Rooke,Alec Birchley,Alexander Adams,A Davies,Amy E. Gaskin,Bree Gatica-Wilcox,Caoimhe McKerr,Catherine Moore,Catryn Williams,Chris Williams,David Heyburn,Elen de Lacy,Ember Hilvers,Fatima Downing,Georgia Pugh,Hannah Jones,Hibo Asad,Jason D. Coombes,Jessica G. Hey,Jessica L. Powell,Joanne Watkins,John Evans,Laia Fina,Laura Gifford,L Gilbert,Lee H. Graham,Malorie Perry,Mari Morgan,Matthew Bull,Nicole Pacchiarini,Noel Craine,Sally Corden,Sara Kumžiene-Summerhayes,Sara Rey,Sarah Taylor,Simon Cottrell,Sophie Jones,Sue Edwards,Tara Annett,Alexander J. Trotter,Alison E. Mather,Alp Aydin,Andrew J. Page,David J. Baker,Ebenezer Foster-Nyarko,Gemma L. Kay,Justin O'Grady,Leonardo de Oliveira Martins,Lizzie Meadows,Nabil-Fareed Alikhan,Sophie J Prosolek,Steven J. Rudder,Thanh Le-Viet,Anna Casey,Liz Ratcliffe,Aditi Singh,Arun Mariappan,Chris L. Baxter,Clara Radulescu,David Simpson,Debra Redman Lavin,Fiona Rogan,Julia Miskelly,Marc Fuchs,Miao Tang,Sílvia F. Carvalho,Stephen Bridgett,Timofey Skvortsov,Zoltán Molnár,Newara Ramadan,Bridget A. Knight,Christopher R. Jones,Cressida Auckland,Helen Morcrette,Jennifer Lee Poyner,Dianne Irish-Tavares,Eric Witele,Jennifer Hart,Tabitha Mahungu,Tanzina Haque,Yann Bourgeois,Christopher Fearn,Kate Cook,Katie F. Loveson,Salman Goudarzi,Cariad Evans,David G Partridge,Katie Johnson,Mehmet Yavus,Mohammad Raza,Craig Mower,Paul Baker,Sarah Essex,Stephen Bonner,Leanne Murray,Louisa K. Watson,Steven P. Liggett,Andrew I. Lawton,Ronan A Lyons,Brendan A I Payne,G Eltringham,Jennifer Collins,Sheila Waugh,Shirelle Burton-Fanning,Yusri Taha,Christopher Jeanes,Andrea N. Gomes,Darren Murray,Maimuna Kimuli,D Dobie,Paula Ashfield,Angus I. Best,Benita Percival,Emma Moles-Garcia,F. Ashford,Jeremy Mirza,L. Crawford,Megan Mayhew,Nicola Cumley,Oliver Megram,Dan Frampton,Judith Heaney,Matthew Byott,C. Houlihan,Charlotte A Williams,Eleni Nastouli,Helen Lowe,John A. Hartley,Judith Breuer,Laurentiu Maftei,Leah Ensell,Marius Cotic,Matteo Mondani,Molly Driscoll,N. Bayzid,Rachel Williams,Sunando Sur Roy,Adhyana I K Mahanama,Buddhini Samaraweera,Eleri Wilson-Davies,Emanuela Pelosi,H.C Umpleby,Helen Wheeler,Jacqui Prieto,Kordo Saeed,Matthew Harvey,Sarah Jeremiah,Siona Silviera,Stephen Aplin,T. Sass,BS Macklin,Dorian Crudgington,Liz Sheridan,Benjamin J. Cogger,Cassandra Malone,Florence Munemo,Hannah Huckson,Jonathan Lewis,Lisa J. Easton,Manasa Mutingwende,Michelle J. Erkiert,Mohammed O. Hassan-Ibrahim,N. Chaloner,Olga Podplomyk,Paul Randell,Roberto Nicodemi,Sarah L. Lowdon,Thomas Somassa,Andrew Beggs,Andrew Hesketh,Colin P. Smith,Giselda Bucca,Christopher Ruis,Claire Cormie,Ellen E. Higginson,Jamie Young,Joana Dias,L. Kermack,Mailis Maes,Ravi Gupta,Sally Forrest,Sophia T. Girgis,Rose K Davidson,Áine O'Toole,Andrew Rambaut,Ben Jackson,Carlos Balcazar,Daniel S. Maloney,Emily Scher,J. McCrone,Katherine A. Williamson,Michael D. Gallagher,Nathan C Medd,Rachel M. Colquhoun,Thomas D. Stanton,Thomas C Williams,Verity Hill,Aaron R. Jeffries,Ben Temperton,Christine Sambles,David J. Studholme,Joanna Warwick-Dugdale,Leigh Jackson,Michelle Michelsen,R. Manley,Stephen L. Michell,Alistair C. Darby,Anita Lucaci,Charlotte Nelson,Claudia Wierzbicki,Edith E. Vamos,Hermione J. Webster,Kathryn A. Jackson,Lucille Rainbow,Margaret Lawrence Hughes,Mark Whitehead,Matthew Gemmell,Miren Iturriza-Gomara,Richard Eccles,Richard Gregory,Sam Haldenby,Steve Paterson,Adrienn Angyal,Alexander J Keeley,Benjamin Foulkes,Benjamin B Lindsey,Dennis Wang,Hailey Hornsby,Luke R. Green,Manoj Baliram Pohare,M. Gallis,Matthew Parker,M. Whiteley,Nikki Smith,P. Wolverson,Peijun Zhang,Samantha Hansford,Sharon N. Hsu,S. Louka,Thushan I de Silva,Timothy M. Freeman,Matilde Mori,Emily J. Park,Jack Hill,Jayasree Dey,Jonathan K. Ball,Joseph G. Chappell,Patrick McClure,Timothy Byaruhanga,A Fanaie,Geraldine Yaze,Rachel A. Hilson,Amy Trebes,Angie Green,David Buck,G. Macintyre-Cockett,John A. Todd,Andrew R. Bassett,Andrew Whitwham,Cordelia Langford,Diana Rajan,Dominic P. Kwiatkowski,J. Harrison,Iraad F. Bronner,Jaime M. Tovar-Corona,Jennifier Liddle,Jillian Durham,Katherine L. Bellis,Kevin Lewis,Louise Aigrain,Nicholas Redshaw,Robert L. Davies,Robin J. Moll,Shane A. McCarthy,Stefanie V Lensing,Steven Leonard,Ben Farr,C. Scott,Charlotte M. Beaver,Cristina V. Ariani,Da Weldon,David Jackson,Emma Betteridge,Gerry Tonkin-Hill,Ian Johnston,Inigo Martincorena,James K. Bonfield,Jeffrey C. Barrett,John Sillitoe,J P Keatley,Karen A. Oliver,Keith James,Lesley Shirley,Liam J. Prestwood,Luke Foulser,Marina Gourtovaia,Matthew J. Dorman,Michael A. Quail,Michael Spencer Chapman,Naomi Park,Rich Livett,Roberto Amato,Sally Kay,Scott Goodwin,Scott Thurston,Shavanthi Rajatileka,Sónia Gonçalves,Stephanie Lo,Theo Sanderson,Alasdair MacLean,Emily Goldstein,Lynne Ferguson,Rachael M. Tomb,Jana Catalan,Neil Jones,John Haughney,Massimo Palmarini,Surajit Ray +672 more
TL;DR: In this article , the authors demonstrate substantial evasion of neutralization by Omicron BA.1 and BA.2 variants in vitro using sera from individuals vaccinated with ChAdOx1, BNT162b2 and mRNA-1273.529.
Journal ArticleDOI
Somatic mutation landscapes at single-molecule resolution
Federico Abascal,Luke M. R. Harvey,Emily G. Mitchell,Emily G. Mitchell,Andrew R. J. Lawson,Stefanie V Lensing,Peter R. Ellis,Andrew Russell,Raul E. Alcantara,Adrian Baez-Ortega,Yichen Wang,Eugene Jing Kwa,Henry Lee-Six,Alex Cagan,Tim H. H. Coorens,Michael Spencer Chapman,Sigurgeir Olafsson,Steven Leonard,David T. Jones,Heather E. Machado,Megan Davies,Nina F. Øbro,Krishnaa T. Mahubani,Kieren Allinson,Moritz Gerstung,Kourosh Saeb-Parsy,David G. Kent,David G. Kent,Elisa Laurenti,Michael R. Stratton,Raheleh Rahbari,Peter J. Campbell,Peter J. Campbell,Robert J. Osborne,Inigo Martincorena +34 more
TL;DR: NanoSeq as discussed by the authors is a duplex sequencing protocol with error rates of less than five errors per billion base pairs in single DNA molecules from cell populations, enabling the study of somatic mutations in any tissue independently of clonality.
Journal ArticleDOI
Exponential growth, high prevalence of SARS-CoV-2, and vaccine effectiveness associated with the Delta variant.
Paul Elliott,D Haw,Haowei Wang,Oliver Eales,Caroline E. Walters,Kylie E. C. Ainslie,Christina Atchison,Claudio Fronterre,Peter J. Diggle,Andrew J. Page,Alexander J. Trotter,Sophie J Prosolek,Deborah Ashby,Christl A. Donnelly,Christl A. Donnelly,Wendy S. Barclay,Graham P. Taylor,Graham S Cooke,Graham S Cooke,Graham S Cooke,Helen Ward,Helen Ward,Helen Ward,Ara Darzi,Steven Riley,Samuel Robson,Nicholas J. Loman,Thomas R. Connor,Tanya Golubchik,Rocio Martinez Nunez,Catherine Ludden,Sally Corden,Ian Johnston,David Bonsall,Colin P. Smith,Ali R Awan,Giselda Bucca,M. Estée Török,Kordo Saeed,Jacqui Prieto,David K. Jackson,William L Hamilton,Luke B Snell,Catherine Moore,Ewan M. Harrison,Sónia Gonçalves,Leigh M Jackson,Ian Goodfellow,Derek Fairley,Matthew W. Loose,Joanne Watkins,Rich Livett,S.E. Moses,Roberto Amato,Samuel M. Nicholls,Matthew J. Bull,Darren Smith,Jeffrey C. Barrett,David M. Aanensen,Martin D. Curran,Surendra Parmar,Dinesh Aggarwal,James Shepherd,Matthew Parker,Sharon Glaysher,Matthew Bashton,Anthony Underwood,Nicole Pacchiarini,Katie F. Loveson,Alessandro M Carabelli,Kate Templeton,Cordelia Langford,John Sillitoe,Thushan I de Silva,Dennis Wang,Dominic P. Kwiatkowski,Andrew Rambaut,Justin O'Grady,Simon Cottrell,Matthew T. G. Holden,E. Thomson,Husam Osman,Monique Andersson,Anoop Chauhan,Mohammed O Hassan-Ibrahim,Mara K. N. Lawniczak,Ravi Gupta,Alex Alderton,Meera Chand,Chrystala Constantinidou,Meera Unnikrishnan,Alistair C. Darby,Julian A. Hiscox,Steve Paterson,Inigo Martincorena,David Robertson,Erik M. Volz,Oliver G. Pybus,Andrew R. Bassett,Cristina V. Ariani,Michael Spencer Chapman,Kathy Li,Rajiv Shah,Natasha Jesudason,Yusri Taha,Martin P McHugh,Rebecca Dewar,Aminu S Jahun,Claire McMurray,Sarojini Pandey,James McKenna,Andrew Nelson,Gregory R Young,Clare M. McCann,Scott Elliott,Hannah Lowe,Ben Temperton,Sunando Roy,Anna Price,Sara Rey,Matthew Wyles,Stefan Rooke,Sharif Shaaban,Mariateresa de Cesare,Laura Letchford,Siona Silveira,Emanuela Pelosi,Eleri Wilson-Davies,Myra Hosmillo,Áine O'Toole,Andrew Hesketh,Richard Stark,Louis du Plessis,Christopher Ruis,Helen Adams,Yann Bourgeois,Stephen L. Michell,Dimitris Grammatopoulos,Jonathan D. Edgeworth,Judith Breuer,John A. Todd,Christophe Fraser,David Buck,Michaela John,Gemma L. Kay,Steve Palmer,Sharon J. Peacock,David Heyburn,Danni Weldon,Esther Robinson,Alan McNally,Peter Muir,Ian B Vipond,John Boyes,Venkat Sivaprakasam,Tranprit Saluja,Samir Dervisevic,Emma Meader,Naomi R Park,Karen Oliver,Aaron R. Jeffries,Sascha Ott,Ana da Silva Filipe,David Simpson,Christopher B. Williams,Jane A. H. Masoli,Bridget A. Knight,Christopher R. Jones,Cherian Koshy,Amy Ash,Anna L. Casey,Andrew Bosworth,Liz Ratcliffe,Li Xu-McCrae,Hannah M Pymont,Stephanie Hutchings,Lisa Berry,Katie Jones,Fenella D. Halstead,Thomas R. A. Davis,Christopher Holmes,Miren Iturriza-Gomara,Anita Lucaci,Paul Randell,Alison Cox,Pinglawathee Madona,Kathryn Ann Harris,Julianne R Brown,Tabitha Mahungu,Dianne Irish-Tavares,Tanzina Haque,Jennifer Hart,Eric Witele,Melisa Louise Fenton,Steven Liggett,Clive Graham,Emma Swindells,Jennifer Collins,Gary Eltringham,Sharon Campbell,Patrick C McClure,Gemma Clark,Tim J Sloan,Carl Jones,Jessica Lynch,Ben Warne,Steven Leonard,Jillian Durham,Thomas N. Williams,Sam Haldenby,Nathaniel Storey,Nabil-Fareed Alikhan,Nadine Holmes,Christopher J. Moore,Matthew Carlile,Malorie Perry,Noel Craine,Ronan A Lyons,Angela Helen Beckett,Salman Goudarzi,Christopher Fearn,Kate B. Cook,Hannah Dent,Hannah Paul,Robert Davies,Beth Blane,Sophia T Girgis,Mathew A. Beale,Katherine L. Bellis,Matthew J. Dorman,Eleanor Drury,Leanne Kane,Sally Kay,Samantha McGuigan,Rachel Nelson,Liam Prestwood,Shavanthi Rajatileka,Rahul Batra,Rachel Williams,Mark Kristiansen,Angie Green,Anita Justice,Adhyana I K Mahanama,Buddhini Samaraweera,Nazreen F. Hadjirin,Joshua Quick,Radoslaw Poplawski,Leanne M Kermack,Nicola Reynolds,Grant Hall,Yasmin Chaudhry,Malte L Pinckert,Iliana Georgana,Robin J Moll,Alicia Thornton,Richard H. Myers,Joanne D. Stockton,Charlotte A Williams,Wen C Yew,Amy Trebes,G MacIntyre-Cockett,Alec Birchley,Alexander Adams,Amy Plimmer,Bree Gatica-Wilcox,Caoimhe McKerr,Ember Hilvers,Hannah Jones,Hibo Asad,Jason Coombes,Johnathan M Evans,Laia Fina,Lauren Gilbert,Lee Graham,Michelle Cronin,Sara Kumziene-Summerhayes,S Taylor,Sophie Jones,Danielle C. Groves,Peijun Zhang,Marta Gallis,Stavroula F Louka,Igor Starinskij,Jon-Paul Keatley,Joshua B Singer,Leonardo de Oliveira Martins,Corin Yeats,Khalil Abudahab,Ben Taylor,Mirko Menegazzo,John Danesh,Wendy Hogsden,Sahar Eldirdiri,Anita Kenyon,Jenifer Mason,Trevor Robinson,Alison Holmes,James V. Price,John A Hartley,Tanya Curran,Alison E. Mather,Giri Shankar,Rachel Jones,Robin Howe,Sian Morgan,Elizabeth Wastenge,Michael R Chapman,Siddharth Mookerjee,Rachael Stanley,Wendy Smith,Tim E. A. Peto,David W Eyre,Derrick W. Crook,Gabrielle Vernet,Christine Kitchen,Huw Gulliver,Ian Merrick,Martyn Guest,Robert J. Munn,Declan Bradley,Tim Wyatt,Charlotte Beaver,Luke Foulser,Sophie Palmer,Carol Churcher,Ellena Brooks,Kim S Smith,Katerina Galai,Georgina M McManus,Frances Bolt,Francesc Coll,Lizzie Meadows,Stephen W Attwood,Alisha Davies,Elen De Lacy,Fatima Downing,Sue Edwards,Garry Scarlett,Sarah Jeremiah,Nikki Smith,Danielle Leek,Sushmita Sridhar,Sally Forrest,Claire Cormie,Harmeet K Gill,Joana Dias,Ellen Higginson,Mailis Maes,Jamie Young,Michelle Wantoch,Dorota Jamrozy,Stephanie W. Lo,Minal Patel,Verity Hill,Claire M Bewshea,Sian Ellard,Cressida Auckland,Ian Harrison,Chloe Bishop,Vicki Chalker,Alex G. Richter,Andrew D Beggs,Angus I. Best,Benita Percival,Jeremy Mirza,Oliver Megram,Megan Mayhew,Liam Crawford,Fiona Ashcroft,Emma Moles-Garcia,Nicola Cumley,Richard Hopes,Patawee Asamaphan,Marc Niebel,Rory Gunson,Amanda Bradley,Alasdair MacLean,Guy Mollett,Rachel Blacow,Paul W Bird,Thomas Helmer,Karlie Fallon,Julian Tang,Antony D Hale,Louissa R Macfarlane-Smith,Katherine L Harper,Holli Carden,Nicholas W Machin,Kathryn A Jackson,Shazaad Ahmad,Ryan P George,Lance Turtle,Elaine O'Toole,Joanne Watts,Cassie Breen,Angela Cowell,Adela Alcolea-Medina,Themoula Charalampous,Amita Patel,Lisa J Levett,Judith Heaney,Aileen G. Rowan,Graham Phillip Taylor,Divya K. Shah,Laura Atkinson,Jack Cd Lee,Adam P Westhorpe,Riaz Jannoo,Helen L Lowe,Angeliki Karamani,Leah Ensell,Wendy Chatterton,Monika Pusok,Ashok Dadrah,Amanda Symmonds,Graciela Sluga,Zoltán Molnár,Paul A. Baker,Stephen Bonner,Sarah Essex,Edward Barton,Debra Padgett,Garren Scott,Jane Greenaway,Brendan A I Payne,Shirelle Burton-Fanning,Sheila Waugh,Veena Raviprakash,Nicola Sheriff,Victoria Blakey,Lesley-Anne Williams,Jonathan W. Moore,Susanne Stonehouse,Louise Smith,Rose K Davidson,Luke Bedford,Lindsay Coupland,Victoria Wright,Joseph G. Chappell,Theocharis Tsoleridis,Jonathan K. Ball,Manjinder Khakh,Vicki M. Fleming,Michelle Lister,Hannah C. Howson-Wells,Louise Berry,Tim Boswell,Amelia Joseph,Iona Willingham,Nichola Duckworth,Sarah Walsh,Emma L. Wise,Nathan Moore,Matilde Mori,Nick Cortes,Stephen P. Kidd,Rebecca Williams Bmbs,Laura Gifford,Kelly Bicknell,Sarah Wyllie,A Lloyd,Robert Impey,Cassandra S Malone,Benjamin J Cogger,Nick Levene,Lynn Monaghan,Alexander J Keeley,David G Partridge,Mohammad Raza,Cariad Evans,Kate M. Johnson,Emma Betteridge,Ben Farr,Scott Goodwin,Michael A. Quail,Carol Scott,Lesley Shirley,Scott Aj Thurston,Diana Rajan,Iraad F. Bronner,Louise Aigrain,Nicholas M Redshaw,Stefanie V Lensing,Shane A. McCarthy,Alex Makunin,Carlos Balcazar,Michael Gallagher,Kathleen A. Williamson,Thomas D Stanton,Michelle L Michelsen,Joanna Warwick-Dugdale,Robin Manley,Audrey Farbos,James W. Harrison,Christine Sambles,David J. Studholme,Angie Lackenby,Tamyo Mbisa,Steven Platt,Shahjahan Miah,David F. Bibby,Carmen F. Manso,Jonathan Hubb,Gavin Dabrera,Mary Ramsay,Daniel Bradshaw,Ulf Schaefer,Natalie Groves,Eileen Gallagher,David N. Lee,David J. Williams,Nicholas Ellaby,Hassan Hartman,Nikos Manesis,Vineet Patel,Juan Ledesma,Katherine A Twohig,Elias Allara,Clare Pearson,Jeffrey K. J. Cheng,Hannah E Bridgewater,Lucy R. Frost,Grace Taylor-Joyce,Paul E Brown,Lily Tong,Alice Broos,Daniel Mair,Jenna Nichols,Stephen Carmichael,Katherine Smollett,Kyriaki Nomikou,Elihu Aranday-Cortes,Natasha M. Johnson,Seema Nickbakhsh,Edith Vamos,Margaret Hughes,Lucille Rainbow,Richard Eccles,Charlotte Nelson,Mark Whitehead,Richard I. Gregory,Matthew Gemmell,Claudia Wierzbicki,Hermione J. Webster,Chloe L Fisher,Adrian W Signell,Gilberto Betancor,Harry D Wilson,Gaia Nebbia,Flavia Flaviani,Alberto C Cerda,Tammy V Merrill,Rebekah E Wilson,Marius Cotic,Nadua Bayzid,Thomas G. Thompson,Erwan Acheson,Steven Rushton,Sarah J. O'Brien,David Baker,Steven Rudder,Alp Aydin,Fei Sang,Johnny Debebe,Sarah François,Tetyana I. Vasylyeva,Marina Escalera Zamudio,Bernardo Gutierrez,Angela Marchbank,Joshua Maksimovic,Karla Spellman,Kathryn McCluggage,M Morgan,Robert Beer,Safiah Afifi,Trudy Workman,William D. Fuller,Catherine Bresner,Adrienn Angyal,Luke R. Green,Paul J. Parsons,Rachel Tucker,Rebecca C H Brown,Max Whiteley,James Bonfield,Christoph Puethe,Andrew Whitwham,Jennifier Liddle,Will P. M. Rowe,Igor Siveroni,Thanh Le-Viet,Amy Gaskin,Robert E. Johnson +592 more
TL;DR: In this article, the authors assessed RT-PCR swab-positivity in the REAL-time Assessment of Community Transmissibility (RACT) in many countries associated with the Delta variant.
Posted ContentDOI
Patterns of within-host genetic diversity in SARS-CoV-2
Gerry Tonkin-Hill,Inigo Martincorena,Roberto Amato,Andrew R. J. Lawson,Moritz Gerstung,Ian Johnston,David K. Jackson,Naomi R Park,Stefanie V Lensing,Michael A. Quail,Sónia Gonçalves,Cristina V. Ariani,Michael Spencer Chapman,William L Hamilton,Luke W. Meredith,Grant Hall,Aminu S Jahun,Yasmin Chaudhry,Myra Hosmillo,Malte L Pinckert,Iliana Georgana,Anna Yakovleva,Laura G Caller,Sarah L Caddy,Theresa Feltwell,Fahad A Khokhar,Charlotte J. Houldcroft,Martin D. Curran,Surendra Parmar,Alex Alderton,Rachel Nelson,Ewan Harrison,John Sillitoe,Stephen D. Bentley,Jeffrey C. Barrett,M. Estée Török,Ian Goodfellow,Cordelia Langford,Dominic P. Kwiatkowski,Dominic P. Kwiatkowski +39 more
TL;DR: In this paper, the authors describe the patterns of within-host diversity in 1,181 SARS-CoV-2 samples sequenced to high depth in duplicate and identify multiple putative examples of co-infection.