M
Martin K. Thomsen
Researcher at Aarhus University
Publications - 37
Citations - 1596
Martin K. Thomsen is an academic researcher from Aarhus University. The author has contributed to research in topics: Prostate & Cancer. The author has an hindex of 18, co-authored 32 publications receiving 1077 citations. Previous affiliations of Martin K. Thomsen include Institute of Cancer Research & BBVA Compass.
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Journal ArticleDOI
Sensing of HSV-1 by the cGAS-STING pathway in microglia orchestrates antiviral defence in the CNS
Line S. Reinert,Katarína Lopušná,Katarína Lopušná,Henriette Winther,Chenglong Sun,Martin K. Thomsen,Ramya Nandakumar,Trine H. Mogensen,Trine H. Mogensen,Morten Meyer,Christian Bjerggaard Vaegter,Jens R. Nyengaard,Katherine A. Fitzgerald,Søren R. Paludan +13 more
TL;DR: Sensing of HSV-1 infection in the CNS by microglia through the cGAS–STING pathway orchestrates an antiviral program that includes type I IFNs and immune-priming of other cell types.
Journal ArticleDOI
Influenza A virus targets a cGAS-independent STING pathway that controls enveloped RNA viruses
Christian K. Holm,Stine H. Rahbek,Hans Henrik Gad,Rasmus O. Bak,Martin R. Jakobsen,Zhaozaho Jiang,Anne Louise Hansen,Simon K. Jensen,Chenglong Sun,Martin K. Thomsen,Anders Laustsen,Camilla G. Nielsen,Kasper Severinsen,Yingluo Xiong,Yingluo Xiong,Dara Burdette,Veit Hornung,Robert Jan Lebbink,Mogens Duch,Katherine A. Fitzgerald,Shervin Bahrami,Jakob Giehm Mikkelsen,Rune Hartmann,Søren R. Paludan +23 more
TL;DR: A STING-dependent, cGAS-independent pathway important for full interferon production and antiviral control of enveloped RNA viruses, including influenza A virus (IAV), which is targeted by IAV is identified.
Journal ArticleDOI
Lack of immunological DNA sensing in hepatocytes facilitates hepatitis B virus infection
Martin K. Thomsen,Ramya Nandakumar,Daniela Stadler,Antje Malo,Roser Marin Valls,Fan Wang,Line S. Reinert,Frederik Dagnæs-Hansen,Anne Kruse Hollensen,Jacob Giehm Mikkelsen,Ulrike Protzer,Søren R. Paludan +11 more
TL;DR: The lack of a functional innate DNA‐sensing pathway in hepatocytes hampers efficient innate control of HBV infection; this may explain why HBV has adapted to specifically replicate in hepatocyte and could contribute to the weak capacity of this cell type to clearHBV infection.
Journal ArticleDOI
SOX9 elevation in the prostate promotes proliferation and cooperates with PTEN loss to drive tumor formation.
Martin K. Thomsen,L. Ambroisine,Sarah L Wynn,Kathryn S.E. Cheah,Christopher S. Foster,Gabrielle Fisher,Daniel M. Berney,Henrik Møller,Victor E. Reuter,Peter T. Scardino,Jack Cuzick,Narasimhan Ragavan,Paras B. Singh,Francis Martin,Christopher Michael Butler,Colin Cooper,Amanda Swain +16 more
TL;DR: Analysis of a cohort of 880 human prostate cancer samples showed that SOX9 expression was associated with increasing Gleason grades and higher Ki67 staining, identifying SOX 9 as part of a developmental pathway that is reactivated in prostate neoplasia where it promotes tumor cell proliferation.
Journal ArticleDOI
Regulation of Steatohepatitis and PPARγ Signaling by Distinct AP-1 Dimers
Sebastian C. Hasenfuss,Sebastian C. Hasenfuss,Latifa Bakiri,Martin K. Thomsen,Evan G. Williams,Johan Auwerx,Erwin F. Wagner +6 more
TL;DR: This unique antagonistic regulation of PPARγ by distinct AP-1 dimers occurs at the transcriptional level and establishesAP-1 as a link between obesity, hepatic lipid metabolism, and NAFLD.