V
Venugopal Gunda
Researcher at University of Nebraska Medical Center
Publications - 47
Citations - 1910
Venugopal Gunda is an academic researcher from University of Nebraska Medical Center. The author has contributed to research in topics: Pancreatic cancer & Cancer. The author has an hindex of 18, co-authored 46 publications receiving 1336 citations. Previous affiliations of Venugopal Gunda include Eppley Institute for Research in Cancer and Allied Diseases & Indian Institute of Chemical Technology.
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Journal ArticleDOI
Combination of ERK and autophagy inhibition as a treatment approach for pancreatic cancer
Kirsten L. Bryant,Clint A. Stalnecker,Daniel Zeitouni,Jennifer E. Klomp,Sen Peng,Andrey P. Tikunov,Venugopal Gunda,Mariaelena Pierobon,Adele Waters,Samuel D. George,Garima Tomar,Björn Papke,G. Aaron Hobbs,Liang Yan,Tikvah K. Hayes,J. Nathaniel Diehl,Gennifer D. Goode,Nina V. Chaika,Yingxue Wang,Guo-Fang Zhang,Agnieszka K. Witkiewicz,Erik S. Knudsen,Emanuel F. Petricoin,Pankaj K. Singh,Jeffrey M. Macdonald,Nhan L. Tran,Costas A. Lyssiotis,Haoqiang Ying,Alec C. Kimmelman,Adrienne D. Cox,Channing J. Der +30 more
TL;DR: It is concluded that combinations of pharmacologic inhibitors that concurrently block both ERK MAPK and autophagic processes that are upregulated in response to ERK inhibition may be effective treatments for PDAC.
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MUC1 and HIF-1alpha Signaling Crosstalk Induces Anabolic Glucose Metabolism to Impart Gemcitabine Resistance to Pancreatic Cancer.
Surendra K. Shukla,Vinee Purohit,Kamiya Mehla,Venugopal Gunda,Nina V. Chaika,Enza Vernucci,Ryan J. King,Jaime Abrego,Gennifer D. Goode,Aneesha Dasgupta,Alysha L. Illies,Teklab Gebregiworgis,Bingbing Dai,Jithesh J. Augustine,Divya Murthy,Kuldeep S. Attri,Oksana Mashadova,Paul M. Grandgenett,Robert Powers,Quan P. Ly,Audrey J. Lazenby,Jean L. Grem,Fang Yu,José M. Matés,John M. Asara,Jung Whan Kim,Jordan Hankins,Colin D. Weekes,Michael A. Hollingsworth,Natalie J. Serkova,Aaron R. Sasson,Jason B. Fleming,Jennifer M. Oliveto,Costas A. Lyssiotis,Lewis C. Cantley,Lyudmyla Berim,Pankaj K. Singh,Pankaj K. Singh +37 more
TL;DR: A widely prevalent mechanism of resistance to gemcitabine in pancreatic cancer is established, whereby increased glycolytic flux leads to glucose addiction in cancer cells and a corresponding increase in pyrimidine biosynthesis to enhance the intrinsic levels of deoxycytidine triphosphate (dCTP).
Journal ArticleDOI
Metabolic reprogramming induced by ketone bodies diminishes pancreatic cancer cachexia
Surendra K. Shukla,Teklab Gebregiworgis,Vinee Purohit,Vinee Purohit,Nina V. Chaika,Venugopal Gunda,Prakash Radhakrishnan,Kamiya Mehla,Iraklis I. Pipinos,Robert Powers,Fang Yu,Pankaj K. Singh +11 more
TL;DR: The studies demonstrate that the cachectic phenotype is in part due to metabolic alterations in tumor cells, which can be reverted by a ketogenic diet, causing reduced tumor growth and inhibition of muscle and body weight loss.
Journal ArticleDOI
De Novo Lipid Synthesis Facilitates Gemcitabine Resistance through Endoplasmic Reticulum Stress in Pancreatic Cancer.
Saber Tadros,Surendra K. Shukla,Ryan J. King,Venugopal Gunda,Enza Vernucci,Jaime Abrego,Nina V. Chaika,Fang Yu,Audrey J. Lazenby,Lyudmyla Berim,Jean L. Grem,Aaron R. Sasson,Pankaj K. Singh +12 more
TL;DR: It is demonstrated that fatty acid biosynthesis pathway manipulation can help overcome the gemcitabine resistance in pancreatic cancer by regulating ER stress and stemness.
Journal ArticleDOI
Long non-coding RNAs and nuclear factor-κB crosstalk in cancer and other human diseases.
Subash C. Gupta,Nikee Awasthee,Vipin Rai,Srinivas Chava,Venugopal Gunda,Kishore B. Challagundla +5 more
TL;DR: The discovery of lncRNAs have provided a new type of regulation for the NF-κB signaling and thus could be explored for therapeutic interventions as well as the challenges associated with the therapeutic interventions of this crosstalk are discussed.