A
Aaron R. Sasson
Researcher at Stony Brook University
Publications - 108
Citations - 7334
Aaron R. Sasson is an academic researcher from Stony Brook University. The author has contributed to research in topics: Pancreatic cancer & Cancer. The author has an hindex of 40, co-authored 107 publications receiving 6220 citations. Previous affiliations of Aaron R. Sasson include Stony Brook University Hospital & Nebraska Medical Center.
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Journal ArticleDOI
Organoid profiling identifies common responders to chemotherapy in pancreatic cancer
Hervé Tiriac,Pascal Belleau,Dannielle D. Engle,Dennis Plenker,Astrid Deschênes,Tim D.D. Somerville,Fieke E. M. Froeling,Richard A. Burkhart,Robert E. Denroche,Gun-Ho Jang,Koji Miyabayashi,C. Megan Young,C. Megan Young,Hardik Patel,Michelle Ma,Joseph F. LaComb,Randze Lerie Palmaira,Ammar A. Javed,Jasmine Huynh,Molly E. Johnson,Kanika Arora,Nicolas Robine,Minita Shah,Rashesh Sanghvi,Austin Goetz,Cinthya Y. Lowder,Laura A. Martello,Else Driehuis,Nicolas Lecomte,Gokce Askan,Christine A. Iacobuzio-Donahue,Hans Clevers,Laura D. Wood,Ralph H. Hruban,Elizabeth D. Thompson,Andrew J. Aguirre,Brian M. Wolpin,Aaron R. Sasson,Joseph Kim,Maoxin Wu,Juan Carlos Bucobo,Peter J. Allen,Divyesh V. Sejpal,William Nealon,James Sullivan,Jordan M. Winter,Phyllis A. Gimotty,Jean L. Grem,Dominick J. DiMaio,Jonathan M. Buscaglia,Paul M. Grandgenett,Jonathan R. Brody,Michael A. Hollingsworth,Grainne M. O'Kane,Faiyaz Notta,Edward J. Kim,James M. Crawford,Craig Devoe,Allyson J. Ocean,Christopher L. Wolfgang,Kenneth H. Yu,Ellen Li,Christopher R. Vakoc,Benjamin Hubert,Sandra Fischer,Sandra Fischer,Julie M. Wilson,Richard A. Moffitt,Jennifer J. Knox,Alexander Krasnitz,Steven Gallinger,Steven Gallinger,Steven Gallinger,David A. Tuveson +73 more
TL;DR: A pancreatic cancer patient-derived organoid (PDO) library is generated that recapitulates the mutational spectrum and transcriptional subtypes of primary Pancreatic cancer and proposes that combined molecular and therapeutic profiling of PDOs may predict clinical response and enable prospective therapeutic selection.
Journal ArticleDOI
Gastric Cancer, Version 2.2013
Jaffer A. Ajani,David J. Bentrem,Stephen Besh,Thomas A. D'Amico,Prajnan Das,Crystal S. Denlinger,Marwan Fakih,Charles S. Fuchs,Hans Gerdes,Robert E. Glasgow,James A. Hayman,James A. Hayman,Wayne L. Hofstetter,David H. Ilson,Rajesh N. Keswani,Lawrence Kleinberg,Lawrence Kleinberg,W. Michael Korn,A. Craig Lockhart,Kenneth L. Meredith,Mary F. Mulcahy,Mark B. Orringer,Mark B. Orringer,James Posey,Aaron R. Sasson,Walter J. Scott,Vivian E. Strong,Thomas K. Varghese,Graham W. Warren,Mary Kay Washington,Christopher G. Willett,Cameron D. Wright,Nicole R. McMillian,Hema Sundar +33 more
TL;DR: The NCCN Clinical Practice Guidelines in Oncology for Gastric Cancer provide evidence- and consensus-based recommendations for a multidisciplinary approach for the management of patients with gastric cancer.
Journal ArticleDOI
Esophageal and esophagogastric junction cancers, version 1.2015.
Jaffer A. Ajani,Thomas A. D'Amico,Khaldoun Almhanna,David J. Bentrem,Stephen Besh,Joseph Chao,Prajnan Das,Crystal S. Denlinger,Paul T. Fanta,Charles S. Fuchs,Hans Gerdes,Robert E. Glasgow,James A. Hayman,Steven N. Hochwald,Wayne L. Hofstetter,David H. Ilson,Dawn E. Jaroszewski,Kory Jasperson,Rajesh N. Keswani,Lawrence Kleinberg,W. Michael Korn,Stephen Leong,A. Craig Lockhart,Mary F. Mulcahy,Mark B. Orringer,James Posey,George A. Poultsides,Aaron R. Sasson,Walter J. Scott,Vivian E. Strong,Thomas K. Varghese,Mary Kay Washington,Christopher G. Willett,Cameron D. Wright,Debra Zelman,Nicole R. McMillian,Hema Sundar +36 more
TL;DR: This portion of the NCCN Guidelines for Esophageal and EGJ Cancers discusses management of locally advanced adenocarcinoma of the esophagus andEGJ.
Journal ArticleDOI
Pancreatic Adenocarcinoma, Version 2.2014
Margaret A. Tempero,Mokenge P. Malafa,Stephen W. Behrman,Al B. Benson,Ephraim S. Casper,E. Gabriela Chiorean,Vincent Chung,Steven J. Cohen,Brian G. Czito,Anitra Engebretson,Mary Feng,William G. Hawkins,Joseph M. Herman,John P. Hoffman,Andrew H. Ko,Srinadh Komanduri,Albert C. Koong,Andrew M. Lowy,Wen Wee Ma,Nipun B. Merchant,Sean J. Mulvihill,Peter Muscarella,Eric K. Nakakura,Jorge Obando,Martha B. Pitman,Sushanth Reddy,Aaron R. Sasson,Sarah P. Thayer,Colin D. Weekes,Robert A. Wolff,Brian M. Wolpin,Jennifer L. Burns,Deborah A. Freedman-Cass +32 more
TL;DR: These NCCN Guidelines Insights summarize major discussion points from the 2014 NCCn Pancreatic Adenocarcinoma Panel meeting, which focused mainly on the management of borderline resectable and locally advanced disease.
Journal ArticleDOI
MUC1 and HIF-1alpha Signaling Crosstalk Induces Anabolic Glucose Metabolism to Impart Gemcitabine Resistance to Pancreatic Cancer.
Surendra K. Shukla,Vinee Purohit,Kamiya Mehla,Venugopal Gunda,Nina V. Chaika,Enza Vernucci,Ryan J. King,Jaime Abrego,Gennifer D. Goode,Aneesha Dasgupta,Alysha L. Illies,Teklab Gebregiworgis,Bingbing Dai,Jithesh J. Augustine,Divya Murthy,Kuldeep S. Attri,Oksana Mashadova,Paul M. Grandgenett,Robert Powers,Quan P. Ly,Audrey J. Lazenby,Jean L. Grem,Fang Yu,José M. Matés,John M. Asara,Jung Whan Kim,Jordan Hankins,Colin D. Weekes,Michael A. Hollingsworth,Natalie J. Serkova,Aaron R. Sasson,Jason B. Fleming,Jennifer M. Oliveto,Costas A. Lyssiotis,Lewis C. Cantley,Lyudmyla Berim,Pankaj K. Singh,Pankaj K. Singh +37 more
TL;DR: A widely prevalent mechanism of resistance to gemcitabine in pancreatic cancer is established, whereby increased glycolytic flux leads to glucose addiction in cancer cells and a corresponding increase in pyrimidine biosynthesis to enhance the intrinsic levels of deoxycytidine triphosphate (dCTP).