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Nissi Varki
Researcher at University of California, San Diego
Publications - 193
Citations - 18035
Nissi Varki is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Sialic acid & Antibody. The author has an hindex of 75, co-authored 188 publications receiving 16502 citations. Previous affiliations of Nissi Varki include University of California, Berkeley & University of Chicago.
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Heparin and cancer revisited: Mechanistic connections involving platelets, P-selectin, carcinoma mucins, and tumor metastasis
TL;DR: Heparin treatment attenuates tumor metastasis in mice by inhibiting P-selectin-mediated interactions of platelets with carcinoma cell-surface mucin ligands, and it is suggested that heparin therapy for metastasis prevention in humans be revisited, with these mechanistic paradigms in mind.
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Disruption of forkhead transcription factor (FOXO) family members in mice reveals their functional diversification
Taisuke Hosaka,William H. Biggs,David Tieu,Antonia D. Boyer,Nissi Varki,Webster K. Cavenee,Karen C. Arden +6 more
TL;DR: It is shown that the physiological roles of Foxo genes are functionally diverse in mammals, and their in vivo physiological roles are largely unknown.
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Human uptake and incorporation of an immunogenic nonhuman dietary sialic acid
Pam Tangvoranuntakul,Pascal Gagneux,Sandra Diaz,Muriel Bardor,Nissi Varki,Ajit Varki,Elaine A. Muchmore +6 more
TL;DR: It is found that Neu5Gc is rare in poultry and fish, common in milk products, and enriched in red meats, and normal humans have variable amounts of circulating IgA, IgM, and IgG antibodies against Neu 5Gc, with the highest levels comparable to those of the previously known anti-α-galactose xenoreactive antibodies.
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Diversity in cell surface sialic acid presentations: implications for biology and disease
Nissi Varki,Ajit Varki +1 more
TL;DR: This review will provide some examples of these diverse roles of Sias, and briefly address immunohistochemical approaches to their detection.
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P-selectin deficiency attenuates tumor growth and metastasis.
TL;DR: It is shown that P-selectin, which normally binds leukocyte ligands, can promote tumor growth and facilitate the metastatic seeding of a mucin-producing carcinoma.