Diversity in cell surface sialic acid presentations: implications for biology and disease
Nissi Varki,Ajit Varki +1 more
TLDR
This review will provide some examples of these diverse roles of Sias, and briefly address immunohistochemical approaches to their detection.About:
This article is published in Laboratory Investigation.The article was published on 2007-09-01 and is currently open access. It has received 490 citations till now. The article focuses on the topics: Sialic Acid Binding Immunoglobulin-like Lectins.read more
Citations
More filters
Journal ArticleDOI
Biological Roles of Glycans
TL;DR: It is time for the diverse functional roles of glycans to be fully incorporated into the mainstream of biological sciences, as they are no different from other major macromolecular building blocks of life, simply more rapidly evolving and complex.
Journal ArticleDOI
Sialic Acids in the Brain: Gangliosides and Polysialic Acid in Nervous System Development, Stability, Disease, and Regeneration
Ronald L. Schnaar,Rita Gerardy-Schahn,Rita Gerardy-Schahn,Herbert Hildebrandt,Herbert Hildebrandt +4 more
TL;DR: In the brain, two families of sialoglycans are of particular interest: gangliosides and polysialic acid as discussed by the authors, which regulate cell-cell interactions, modulate the activities of their glycoprotein and glycolipid scaffolds as well as other cell surface molecules.
Journal ArticleDOI
Terminal sugars of Fc glycans influence antibody effector functions of IgGs.
TL;DR: Structural studies indicate that the presence or absence of specific terminal sugars may affect hydrophilic and hydrophobic interactions between sugar residues and amino acid residues in the Fc fragment, which in turn may impact antibody effector functions.
Journal ArticleDOI
Delivery of therapeutic proteins.
TL;DR: This review includes a general discussion on covalent attachment of poly(ethylene glycol) (PEG), polysialic acid, or glycolic acid as well as developing new formulations containing nanoparticulate or colloidal systems (e.g., liposomes, polymeric microspheres,polymeric nanoparticles).
Journal ArticleDOI
Mucins: A biologically relevant glycan barrier in mucosal protection
TL;DR: Mucin biology is dynamic and the processes of degradation and turnover are well integrated with biosynthesis to maintain a continuous mucosal protection against all external aggressive forces.
References
More filters
Book
Essentials of Glycobiology
Ajit Varki,Richard D. Cummings,Jeffrey D. Esko,Hudson H. Freeze,Pamela Stanley,Carolyn R. Bertozzi,Gerald W. Hart,Marilynn E. Etzler +7 more
TL;DR: General principles - historical background and overview saccharide structure and nomenclature evolution of glycan diversity protein-glycan Interactions exploring the biological roles of glycans biosynthesis, metabolism, and function.
Journal ArticleDOI
Siglecs and their roles in the immune system
TL;DR: The postulated functions of the recently discovered CD33-related Siglecs are discussed and the factors that seem to be driving their rapid evolution are considered.
Journal ArticleDOI
Avian flu: influenza virus receptors in the human airway.
TL;DR: An anatomical difference in the distribution in the human airway of the different binding molecules preferred by the avian and human influenza viruses is demonstrated to provide a rational explanation for why H5N1 viruses at present rarely infect and spread between humans although they can replicate efficiently in the lungs.
Journal ArticleDOI
Chemical Diversity in the Sialic Acids and Related α-Keto Acids: An Evolutionary Perspective
Takashi Angata,Ajit Varki +1 more
Journal ArticleDOI
History of lectins: from hemagglutinins to biological recognition molecules
Nathan Sharon,Halina Lis +1 more
TL;DR: A brief account of 100-plus years of lectin research is presented to show how these proteins have become the focus of intense interest for biologists and in particular for the glycobiologists among them.