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Noah Dephoure
Researcher at Cornell University
Publications - 78
Citations - 12695
Noah Dephoure is an academic researcher from Cornell University. The author has contributed to research in topics: Phosphorylation & Cell cycle. The author has an hindex of 35, co-authored 70 publications receiving 11125 citations. Previous affiliations of Noah Dephoure include University of California, San Francisco & NewYork–Presbyterian Hospital.
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Journal ArticleDOI
Global analysis of protein expression in yeast
Sina Ghaemmaghami,Won-Ki Huh,Kiowa Bower,Russell W. Howson,Archana Belle,Noah Dephoure,Erin K. O'Shea,Jonathan S. Weissman +7 more
TL;DR: A Saccharomyces cerevisiae fusion library is created where each open reading frame is tagged with a high-affinity epitope and expressed from its natural chromosomal location, and it is found that about 80% of the proteome is expressed during normal growth conditions.
Journal ArticleDOI
A quantitative atlas of mitotic phosphorylation.
Noah Dephoure,Chunshui Zhou,Judit Villén,Sean A. Beausoleil,Corey E. Bakalarski,Stephen J. Elledge,Steven P. Gygi +6 more
TL;DR: Analysis of non-proline site-containing phosphopeptides identified two unique motifs that suggest there are at least two undiscovered mitotic kinases, suggesting that many of the proteins identified may be CDK substrates.
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A mitochondrial pyruvate carrier required for pyruvate uptake in yeast, Drosophila, and humans.
Daniel K. Bricker,Eric B. Taylor,John C. Schell,Thomas Orsak,Audrey Boutron,Yu-Chan Chen,James E. Cox,Caleb M. Cardon,Jonathan G. Van Vranken,Noah Dephoure,Claire Redin,Sihem Boudina,Steven P. Gygi,Michèle Brivet,Carl S. Thummel,Jared Rutter +15 more
TL;DR: Human genetic studies of three families with children suffering from lactic acidosis and hyperpyruvatemia revealed a causal locus that mapped to MPC1, changing single amino acids that are conserved throughout eukaryotes, demonstrating that Mpc1 and Mpc2 form an essential part of the mitochondrial pyruvate carrier.
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SDH5, a Gene Required for Flavination of Succinate Dehydrogenase, Is Mutated in Paraganglioma
Huai Xiang Hao,Oleh Khalimonchuk,Margit Schraders,Noah Dephoure,Jean-Pierre Bayley,Henricus P. M. Kunst,Peter Devilee,Cor W. R. J. Cremers,Joshua D. Schiffman,Brandon G. Bentz,Steven P. Gygi,Dennis R. Winge,Hannie Kremer,Jared Rutter +13 more
TL;DR: A combination of bioinformatics, yeast genetics, biochemistry, and human genetics was used to show that a previously uncharacterized mitochondrial protein (Sdh5) is required for the activity of respiratory complex II, leading to the discovery of a human tumor susceptibility gene.
Journal ArticleDOI
A chromatin localization screen reveals poly (ADP ribose)-regulated recruitment of the repressive polycomb and NuRD complexes to sites of DNA damage
Danny M. Chou,Brittany Susan Adamson,Noah Dephoure,Xu Tan,Amanda C. Nottke,Kristen E. Hurov,Steven P. Gygi,Monica P. Colaiácovo,Stephen J. Elledge +8 more
TL;DR: It is proposed that PARP sets up a transient repressive chromatin structure at sites of DNA damage to block transcription and facilitate DNA repair.