N
Nobuhiro Yamada
Researcher at University of Tsukuba
Publications - 402
Citations - 27466
Nobuhiro Yamada is an academic researcher from University of Tsukuba. The author has contributed to research in topics: Diabetes mellitus & Cholesterol. The author has an hindex of 82, co-authored 402 publications receiving 25572 citations. Previous affiliations of Nobuhiro Yamada include University of Tokyo & Kyoto University.
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Journal ArticleDOI
Cardiorespiratory Fitness as a Quantitative Predictor of All-Cause Mortality and Cardiovascular Events in Healthy Men and Women: A Meta-analysis
Satoru Kodama,Kazumi Saito,Shiro Tanaka,Miho Maki,Yoko Yachi,Mihoko Asumi,Ayumi Sugawara,Kumiko Totsuka,Hitoshi Shimano,Yasuo Ohashi,Nobuhiro Yamada,Hirohito Sone +11 more
TL;DR: In this article, a systematic literature search was conducted for observational cohort studies using MEDLINE (1966 to December 31, 2008) and EMBASE (1980 to December 30, 2008), which reported associations of baseline cardiorespiratory fitness with CHD events, CVD events, or all-cause mortality in healthy participants.
Journal ArticleDOI
Sterol Regulatory Element-binding Protein-1 as a Key Transcription Factor for Nutritional Induction of Lipogenic Enzyme Genes
Hitoshi Shimano,Naoya Yahagi,Michiyo Amemiya-Kudo,Alyssa H. Hasty,Jun-ichi Osuga,Yoshiaki Tamura,Futoshi Shionoiri,Yoko Iizuka,Ken Ohashi,Kenji Harada,Takanari Gotoda,Shun Ishibashi,Nobuhiro Yamada +12 more
TL;DR: It is demonstrated that SREBP-1 plays a crucial role in the induction of lipogenesis but not cholesterol biosynthesis in liver when excess energy by carbohydrates is consumed.
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Targeted disruption of hormone-sensitive lipase results in male sterility and adipocyte hypertrophy, but not in obesity
Jun-ichi Osuga,Shun Ishibashi,Teruaki Oka,Hiroaki Yagyu,Ryu-ichi Tozawa,Akihisa Fujimoto,Futoshi Shionoiri,Naoya Yahagi,Frederic B. Kraemer,Osamu Tsutsumi,Nobuhiro Yamada +10 more
TL;DR: It is shown that HSL is required for spermatogenesis but is not the only enzyme that mediates the hydrolysis of triacylglycerol stored in adipocytes, and that adipocytes were significantly enlarged and the size differences between cell and tissue suggests the heterogeneity of adipocytes.
Journal ArticleDOI
Effect of aerobic exercise training on serum levels of high-density lipoprotein cholesterol: a meta-analysis
Satoru Kodama,Shiro Tanaka,Kazumi Saito,Miao Shu,Yasuko Sone,Fumiko Onitake,Emiko Suzuki,Hitoshi Shimano,Shigeru Yamamoto,Kazuo Kondo,Yasuo Ohashi,Nobuhiro Yamada,Hirohito Sone +12 more
TL;DR: There appears to exist a minimum exercise volume for a significant increase in HDL-C level, and exercise duration per session was the most important element of an exercise prescription.
Journal ArticleDOI
Identification of Liver X Receptor-Retinoid X Receptor as an Activator of the Sterol Regulatory Element-Binding Protein 1c Gene Promoter
Tomohiro Yoshikawa,Hitoshi Shimano,Michiyo Amemiya-Kudo,Naoya Yahagi,Alyssa H. Hasty,Takashi Matsuzaka,Hiroaki Okazaki,Yoshiaki Tamura,Yoko Iizuka,Ken Ohashi,Jun-ichi Osuga,Kenji Harada,Takanari Gotoda,Satoshi Kimura,Shun Ishibashi,Nobuhiro Yamada +15 more
TL;DR: It is demonstrated that LXR-RXR can modify the expression of genes for lipogenic enzymes by regulating SREBP-1c expression, providing a novel link between fatty acid and cholesterol metabolism.