O
Olivier Disson
Researcher at Pasteur Institute
Publications - 46
Citations - 3897
Olivier Disson is an academic researcher from Pasteur Institute. The author has contributed to research in topics: Listeria monocytogenes & Virulence. The author has an hindex of 22, co-authored 39 publications receiving 3069 citations. Previous affiliations of Olivier Disson include French Institute of Health and Medical Research & Centre national de la recherche scientifique.
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Journal ArticleDOI
A mouse model for Chikungunya: young age and inefficient type-I interferon signaling are risk factors for severe disease.
Thérèse Couderc,Fabrice Chrétien,Clémentine Schilte,Olivier Disson,Madly Brigitte,Florence Guivel-Benhassine,Yasmina Touret,G. Barau,Nadège Cayet,Isabelle Schuffenecker,Philippe Desprès,Fernando Arenzana-Seisdedos,Alain Michault,Matthew L. Albert,Marc Lecuit +14 more
TL;DR: It is shown that whereas wild type (WT) adult mice are resistant to CHIKV infection, WT mouse neonates are susceptible and neonatal disease severity is age-dependent, and the neonatal phase and inefficient type-I IFN signaling as risk factors for severe CHikV-associated disease are identified.
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Uncovering Listeria monocytogenes hypervirulence by harnessing its biodiversity
Mylène M. Maury,Mylène M. Maury,Mylène M. Maury,Yu Huan Tsai,Yu Huan Tsai,Caroline Charlier,Marie Touchon,Marie Touchon,Viviane Chenal-Francisque,Viviane Chenal-Francisque,Alexandre Leclercq,Alexandre Leclercq,Alexis Criscuolo,Charlotte Gaultier,Charlotte Gaultier,Sophie Roussel,Anne Brisabois,Olivier Disson,Olivier Disson,Eduardo P. C. Rocha,Eduardo P. C. Rocha,Sylvain Brisse,Sylvain Brisse,Marc Lecuit +23 more
TL;DR: This study integrated human epidemiological and clinical data with bacterial population genomics to harness the biodiversity of the model foodborne pathogen Listeria monocytogenes and decipher the basis of its neural and placental tropisms.
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Liver-Resident Macrophage Necroptosis Orchestrates Type 1 Microbicidal Inflammation and Type-2-Mediated Tissue Repair during Bacterial Infection
Camille Blériot,Théo Dupuis,Théo Dupuis,Grégory Jouvion,Gérard Eberl,Olivier Disson,Olivier Disson,Marc Lecuit +7 more
TL;DR: Kupffer cell death is a key signal orchestrating type 1 microbicidal inflammation and type-2-mediated liver repair upon infection, indicating that beyond the classical dichotomy of type 1 and type 2 responses, these responses can develop sequentially in the context of a bacterial infection and act interdependently, orchestrating liver immune responses and return to homeostasis.
Journal ArticleDOI
The surface protein HvgA mediates group B streptococcus hypervirulence and meningeal tropism in neonates
Asmaa Tazi,Asmaa Tazi,Olivier Disson,Olivier Disson,Samuel Bellais,Samuel Bellais,Abdelouhab Bouaboud,Abdelouhab Bouaboud,Nicolas Dmytruk,Shaynoor Dramsi,Michel-Yves Mistou,Huot Khun,Charlotte Mechler,Isabelle Tardieux,Isabelle Tardieux,Patrick Trieu-Cuot,Marc Lecuit,Marc Lecuit,Marc Lecuit,Claire Poyart +19 more
TL;DR: Lethal meningitis triggered by the hypervirulent group B streptococcus clone ST-17 is mediated by a novel surface protein called HvgA.
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Conjugated action of two species-specific invasion proteins for fetoplacental listeriosis
Olivier Disson,Olivier Disson,Solène Grayo,Solène Grayo,Eugénie Huillet,Eugénie Huillet,Eugénie Huillet,Georgios Nikitas,Georgios Nikitas,Francina Langa-Vives,Olivier Dussurget,Olivier Dussurget,Olivier Dussurget,Marie Ragon,Alban Le Monnier,Charles Babinet,Pascale Cossart,Pascale Cossart,Pascale Cossart,Marc Lecuit +19 more
TL;DR: Using the gerbil, a natural host for L. monocytogenes, and a knock-in mouse line ubiquitously expressing humanized E-cadherin, the essential and interdependent roles of InlA and InlB in fetoplacental listeriosis are uncovered and the molecular mechanism underlying the ability of a microbe to target and cross the placental barrier is deciphered.