Olof Karlberg

TL;DR: Se sequencing and deep analysis of messenger RNA and microRNA from lymphoblastoid cell lines of 462 individuals from the 1000 Genomes Project—the first uniformly processed high-throughput RNA-sequencing data from multiple human populations with high-quality genome sequences discover extremely widespread genetic variation affecting the regulation of most genes.

TL;DR: The strong relationship with alpha-proteobacterial genes observed for some mitochondrial genes, combined with the lack of such a relationship for others, indicates that the modern mitochondrial proteome is the product of both reductive and expansive processes.

TL;DR: It is concluded that distributing RNA sequencing among different laboratories is feasible, given proper standardization and randomization procedures, and a set of quality measures and guidelines for assessing technical biases in RNA-seq data are provided.

TL;DR: The proposed scheme for the origin of mitochondria based on phylogenetic reconstructions with more than 400 yeast nuclear genes that encode mitochondrial proteins suggests that the majority of genes encoding yeast mitochondrial proteins are descendants of two different genomic lineages that have evolved in different modes.

TL;DR: The results are consistent with an early duplication and divergence of the five ATP/ADP translocases within the rickettsial lineage, and a comparison of the phylogenetic depths of the mitochondrial and the plastid/parasite ATP/adsp translocase indicates a deep origin for both transporters.