Ismael Padioleau

TL;DR: Se sequencing and deep analysis of messenger RNA and microRNA from lymphoblastoid cell lines of 462 individuals from the 1000 Genomes Project—the first uniformly processed high-throughput RNA-sequencing data from multiple human populations with high-quality genome sequences discover extremely widespread genetic variation affecting the regulation of most genes.

TL;DR: It is shown that unlike genetic regulatory variation, DNA methylation alone does not significantly drive allele specific expression, and inferred mechanistic relationships using genetic variation as well as correlations with TF abundance reveal both a passive and active role of DNAmethylation to regulatory interactions influencing gene expression.

TL;DR: This work quantified allelic variability in transcription factor binding, histone modifications, and gene expression within humans and found abundant allelic specificity in chromatin and extensive local, short-range, and long-range allelic coordination among the studied molecular phenotypes.

TL;DR: It is proposed that local, sequence-independent chromatin variation emerges as a result of genetic perturbations in cooperative interactions between cis-regulatory elements that are located within the same genomic domain.

TL;DR: High-resolution analyses are provided showing how genome sequence variation has a broad effect on cellular phenotypes across cell-types, whereas epigenetic factors provide a secondary layer of variation that is more tissue-specific.