O
Omid C. Farokhzad
Researcher at Brigham and Women's Hospital
Publications - 340
Citations - 75194
Omid C. Farokhzad is an academic researcher from Brigham and Women's Hospital. The author has contributed to research in topics: Drug delivery & Aptamer. The author has an hindex of 110, co-authored 329 publications receiving 64226 citations. Previous affiliations of Omid C. Farokhzad include Beth Israel Deaconess Medical Center & Columbia University.
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Nanoparticles in Medicine: Therapeutic Applications and Developments
TL;DR: Nanomaterials have unique physicochemical properties, such as ultra small size, large surface area to mass ratio, and high reactivity, which are different from bulk materials of the same composition, which can be used to overcome some of the limitations found in traditional therapeutic and diagnostic agents.
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Cancer Nanotechnology: The impact of passive and active targeting in the era of modern cancer biology
TL;DR: The fundamental concepts of enhanced permeability and retention effect (EPR) are revisited and the mechanisms proposed to enhance preferential "retention" in the tumor, whether using active targeting of nanoparticles, binding of drugs to their tumoral targets or the presence of tumor associated macrophages are explored.
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Degradable Controlled-Release Polymers and Polymeric Nanoparticles: Mechanisms of Controlling Drug Release
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Targeted nanoparticle-aptamer bioconjugates for cancer chemotherapy in vivo
Omid C. Farokhzad,Jianjun Cheng,Jianjun Cheng,Benjamin A. Teply,Ines Sherifi,Sangyong Jon,Philip W. Kantoff,Jerome P. Richie,Robert Langer,Robert Langer +9 more
TL;DR: The potential utility of nanoparticle-aptamer bioconjugates for a therapeutic application is demonstrated and remarkable efficacy and reduced toxicity as measured by mean body weight loss (BWL) in vivo are demonstrated.
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Cellular uptake of nanoparticles: journey inside the cell.
Shahed Behzadi,Vahid Serpooshan,Wei Tao,Majd A. Hamaly,Mahmoud Y. Alkawareek,Erik C. Dreaden,Dennis Brown,Alaaldin M. Alkilany,Omid C. Farokhzad,Omid C. Farokhzad,Morteza Mahmoudi,Morteza Mahmoudi +11 more
TL;DR: This review provides an objective and comprehensive account of the cellular uptake of NPs and the underlying parameters controlling the nano-cellular interactions, along with the available analytical techniques to follow and track these processes.