Yuri Ishizu

TL;DR: It is shown that enhancers share properties with CpG-poor messenger RNA promoters but produce bidirectional, exosome-sensitive, relatively short unspliced RNAs, the generation of which is strongly related to enhancer activity.

TL;DR: For example, the authors mapped transcription start sites (TSSs) and their usage in human and mouse primary cells, cell lines and tissues to produce a comprehensive overview of mammalian gene expression across the human body.

TL;DR: The data support a highly generalizable model in which enhancer transcription is the earliest event in successive waves of transcriptional change during cellular differentiation or activation.

TL;DR: An integrated expression atlas of miRNAs and their promoters by deep-sequencing 492 short RNA libraries, with matching Cap Analysis Gene Expression (CAGE) data, is created, establishing a foundation for detailed analysis of miRNA expression patterns and transcriptional control regions.

TL;DR: Deep cap analysis of gene expression on skin-derived MCs is employed to generate the most comprehensive view of the human MC transcriptome ever reported, demonstrating that MCs possess a unique and surprising transcriptional landscape.