C
Christine Brennan
Researcher at University of Michigan
Publications - 11
Citations - 4118
Christine Brennan is an academic researcher from University of Michigan. The author has contributed to research in topics: Prostate cancer & Exome. The author has an hindex of 10, co-authored 11 publications receiving 3292 citations.
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Journal ArticleDOI
Integrative clinical genomics of advanced prostate cancer
Dan R. Robinson,Eliezer M. Van Allen,Eliezer M. Van Allen,Yi-Mi Wu,Nikolaus Schultz,Robert J. Lonigro,Juan Miguel Mosquera,Bruce Montgomery,Mary-Ellen Taplin,Colin C. Pritchard,Gerhardt Attard,Gerhardt Attard,Himisha Beltran,Wassim Abida,Robert K. Bradley,Jake Vinson,Xuhong Cao,Pankaj Vats,Lakshmi P. Kunju,Maha Hussain,Felix Y. Feng,Scott A. Tomlins,Kathleen A. Cooney,David Smith,Christine Brennan,Javed Siddiqui,Rohit Mehra,Yu Chen,Yu Chen,Dana E. Rathkopf,Dana E. Rathkopf,Michael J. Morris,Michael J. Morris,Stephen B. Solomon,Jeremy C. Durack,Victor E. Reuter,Anuradha Gopalan,Jianjiong Gao,Massimo Loda,Rosina T. Lis,Michaela Bowden,Michaela Bowden,Stephen P. Balk,Glenn C. Gaviola,Carrie Sougnez,Manaswi Gupta,Evan Y. Yu,Elahe A. Mostaghel,Heather H. Cheng,Hyojeong Mulcahy,Lawrence D. True,Stephen R. Plymate,Heidi Dvinge,Roberta Ferraldeschi,Roberta Ferraldeschi,Penny Flohr,Penny Flohr,Susana Miranda,Susana Miranda,Zafeiris Zafeiriou,Zafeiris Zafeiriou,Nina Tunariu,Nina Tunariu,Joaquin Mateo,Joaquin Mateo,Raquel Perez-Lopez,Raquel Perez-Lopez,Francesca Demichelis,Francesca Demichelis,Brian D. Robinson,Marc H. Schiffman,David M. Nanus,Scott T. Tagawa,Alexandros Sigaras,Kenneth Eng,Olivier Elemento,Andrea Sboner,Elisabeth I. Heath,Howard I. Scher,Howard I. Scher,Kenneth J. Pienta,Philip W. Kantoff,Johann S. de Bono,Johann S. de Bono,Mark A. Rubin,Peter S. Nelson,Levi A. Garraway,Levi A. Garraway,Charles L. Sawyers,Arul M. Chinnaiyan +89 more
TL;DR: This cohort study provides clinically actionable information that could impact treatment decisions for affected individuals and identified new genomic alterations in PIK3CA/B, R-spondin, BRAF/RAF1, APC, β-catenin, and ZBTB16/PLZF.
Journal ArticleDOI
Erratum: Integrative Clinical Genomics of Advanced Prostate Cancer
Dan R. Robinson,Eliezer M. Van Allen,Yi-Mi Wu,Nikolaus Schultz,Robert J. Lonigro,Juan Miguel Mosquera,Bruce Montgomery,Mary-Ellen Taplin,Colin C. Pritchard,Gerhardt Attard,Himisha Beltran,Wassim Abida,Robert K. Bradley,Jake Vinson,Xuhong Cao,Pankaj Vats,Lakshmi P. Kunju,Maha Hussain,Felix Y. Feng,Scott A. Tomlins,Kathleen A. Cooney,David Smith,Christine Brennan,Javed Siddiqui,Rohit Mehra,Yu Chen,Dana E. Rathkopf,Michael J. Morris,Stephen B. Solomon,Jeremy C. Durack,Victor E. Reuter,Anuradha Gopalan,Jianjiong Gao,Massimo Loda,Rosina T. Lis,Michaela Bowden,Stephen P. Balk,Glenn C. Gaviola,Carrie Sougnez,Manaswi Gupta,Evan Y. Yu,Elahe A. Mostaghel,Heather H. Cheng,Hyojeong Mulcahy,Lawrence D. True,Stephen R. Plymate,Heidi Dvinge,Roberta Ferraldeschi,Penny Flohr,Susana Miranda,Zafeiris Zafeiriou,Nina Tunariu,Joaquin Mateo,Raquel Perez-Lopez,Francesca Demichelis,Brian D. Robinson,Andrea Sboner,Marc H. Schiffman,David M. Nanus,Scott T. Tagawa,Alexandros Sigaras,Kenneth Eng,Olivier Elemento,Elisabeth I. Heath,Howard I. Scher,Kenneth J. Pienta,Philip W. Kantoff,Johann S. de Bono,Mark A. Rubin,Peter S. Nelson,Levi A. Garraway,Charles L. Sawyers,Arul M. Chinnaiyan +72 more
TL;DR: Dan Robinson, Eliezer M. Robinson, Andrea Sboner, Marc Schiffman, David M. Smith, Christine Brennan, Javed Siddiqui, Rohit Mehra, Yu Chen, Dana E. Rathkopf, Michael J. Morris, Stephen B. Solomon, Jeremy C. Tomlins, Kathleen A. Reuter, Anuradha Gopalan, Jianjiong Gao, Massimo Loda, Rosina T.
Journal ArticleDOI
Genetic variants regulating immune cell levels in health and disease
Valeria Orrù,Maristella Steri,Gabriella Sole,Carlo Sidore,Carlo Sidore,Francesca Virdis,Mariano Dei,Sandra Lai,Magdalena Zoledziewska,Fabio Busonero,Antonella Mulas,Matteo Floris,Wieslawa I. Mentzen,Silvana Anna Maria Urru,Stefania Olla,Michele Marongiu,Maria Grazia Piras,Monia Lobina,Andrea Maschio,Maristella Pitzalis,Maria Francesca Urru,Marco Marcelli,Roberto Cusano,Francesca Deidda,Valentina Serra,Manuela Oppo,Rosella Pilu,Frederic Reinier,Riccardo Berutti,Luca Pireddu,Ilenia Zara,Eleonora Porcu,Alan Kwong,Christine Brennan,Brendan Tarrier,Robert H. Lyons,Hyun Min Kang,Sergio Uzzau,Rossano Atzeni,M. Valentini,Davide Firinu,Lidia Leoni,Gianluca Rotta,Silvia Naitza,Andrea Angius,Mauro Congia,Michael B. Whalen,Chris Jones,David Schlessinger,Gonçalo R. Abecasis,Edoardo Fiorillo,Serena Sanna,Francesco Cucca +52 more
TL;DR: Genetic contributions to quantitative levels of 95 cell types encompassing 272 immune traits, in a cohort of 1,629 individuals from four clustered Sardinian villages are reported, connecting specific cellular phenotypes to specific genetic variants, helping to explicate their involvement in disease.
Journal ArticleDOI
Genome sequencing elucidates Sardinian genetic architecture and augments association analyses for lipid and blood inflammatory markers
Carlo Sidore,Fabio Busonero,Andrea Maschio,Eleonora Porcu,Silvia Naitza,Magdalena Zoledziewska,Antonella Mulas,Giorgio Pistis,Maristella Steri,Fabrice Danjou,Alan Kwong,Vicente Diego Ortega Del Vecchyo,Charleston W. K. Chiang,Jennifer L. Bragg-Gresham,Maristella Pitzalis,Ramaiah Nagaraja,Brendan Tarrier,Christine Brennan,Sergio Uzzau,Christian Fuchsberger,Rossano Atzeni,Frederic Reinier,Riccardo Berutti,Jie Huang,Nicholas J. Timpson,Daniela Toniolo,Paolo Gasparini,Giovanni Malerba,George Dedoussis,Eleftheria Zeggini,Nicole Soranzo,Chris Jones,Robert H. Lyons,Andrea Angius,Hyun Min Kang,John Novembre,Serena Sanna,David Schlessinger,Francesco Cucca,Gonçalo R. Abecasis +39 more
TL;DR: The new associations would have been missed in analyses based on 1000 Genomes Project data, underlining the advantages of large-scale sequencing in this founder population of Sardinians.
Journal ArticleDOI
The use of exome capture RNA-seq for highly degraded RNA with application to clinical cancer sequencing
Marcin Cieslik,Rashmi Chugh,Yi-Mi Wu,Ming Wu,Christine Brennan,Robert J. Lonigro,Fengyun Su,Rui Wang,Javed Siddiqui,Rohit Mehra,Xuhong Cao,David R. Lucas,Arul M. Chinnaiyan,Dan R. Robinson +13 more
TL;DR: An exome-capture transcriptome protocol with greatly improved performance on degraded RNA is developed and the utility of capture RNA-seq libraries in a patient with a highly malignant solitary fibrous tumor enrolled in the clinical sequencing program called MI-ONCOSEQ is demonstrated.