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Alexandros Sigaras
Researcher at Cornell University
Publications - 19
Citations - 3826
Alexandros Sigaras is an academic researcher from Cornell University. The author has contributed to research in topics: Cancer & Prostate cancer. The author has an hindex of 10, co-authored 17 publications receiving 2951 citations. Previous affiliations of Alexandros Sigaras include Columbia University & NewYork–Presbyterian Hospital.
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Journal ArticleDOI
Integrative clinical genomics of advanced prostate cancer
Dan R. Robinson,Eliezer M. Van Allen,Eliezer M. Van Allen,Yi-Mi Wu,Nikolaus Schultz,Robert J. Lonigro,Juan Miguel Mosquera,Bruce Montgomery,Mary-Ellen Taplin,Colin C. Pritchard,Gerhardt Attard,Gerhardt Attard,Himisha Beltran,Wassim Abida,Robert K. Bradley,Jake Vinson,Xuhong Cao,Pankaj Vats,Lakshmi P. Kunju,Maha Hussain,Felix Y. Feng,Scott A. Tomlins,Kathleen A. Cooney,David Smith,Christine Brennan,Javed Siddiqui,Rohit Mehra,Yu Chen,Yu Chen,Dana E. Rathkopf,Dana E. Rathkopf,Michael J. Morris,Michael J. Morris,Stephen B. Solomon,Jeremy C. Durack,Victor E. Reuter,Anuradha Gopalan,Jianjiong Gao,Massimo Loda,Rosina T. Lis,Michaela Bowden,Michaela Bowden,Stephen P. Balk,Glenn C. Gaviola,Carrie Sougnez,Manaswi Gupta,Evan Y. Yu,Elahe A. Mostaghel,Heather H. Cheng,Hyojeong Mulcahy,Lawrence D. True,Stephen R. Plymate,Heidi Dvinge,Roberta Ferraldeschi,Roberta Ferraldeschi,Penny Flohr,Penny Flohr,Susana Miranda,Susana Miranda,Zafeiris Zafeiriou,Zafeiris Zafeiriou,Nina Tunariu,Nina Tunariu,Joaquin Mateo,Joaquin Mateo,Raquel Perez-Lopez,Raquel Perez-Lopez,Francesca Demichelis,Francesca Demichelis,Brian D. Robinson,Marc H. Schiffman,David M. Nanus,Scott T. Tagawa,Alexandros Sigaras,Kenneth Eng,Olivier Elemento,Andrea Sboner,Elisabeth I. Heath,Howard I. Scher,Howard I. Scher,Kenneth J. Pienta,Philip W. Kantoff,Johann S. de Bono,Johann S. de Bono,Mark A. Rubin,Peter S. Nelson,Levi A. Garraway,Levi A. Garraway,Charles L. Sawyers,Arul M. Chinnaiyan +89 more
TL;DR: This cohort study provides clinically actionable information that could impact treatment decisions for affected individuals and identified new genomic alterations in PIK3CA/B, R-spondin, BRAF/RAF1, APC, β-catenin, and ZBTB16/PLZF.
Journal ArticleDOI
Erratum: Integrative Clinical Genomics of Advanced Prostate Cancer
Dan R. Robinson,Eliezer M. Van Allen,Yi-Mi Wu,Nikolaus Schultz,Robert J. Lonigro,Juan Miguel Mosquera,Bruce Montgomery,Mary-Ellen Taplin,Colin C. Pritchard,Gerhardt Attard,Himisha Beltran,Wassim Abida,Robert K. Bradley,Jake Vinson,Xuhong Cao,Pankaj Vats,Lakshmi P. Kunju,Maha Hussain,Felix Y. Feng,Scott A. Tomlins,Kathleen A. Cooney,David Smith,Christine Brennan,Javed Siddiqui,Rohit Mehra,Yu Chen,Dana E. Rathkopf,Michael J. Morris,Stephen B. Solomon,Jeremy C. Durack,Victor E. Reuter,Anuradha Gopalan,Jianjiong Gao,Massimo Loda,Rosina T. Lis,Michaela Bowden,Stephen P. Balk,Glenn C. Gaviola,Carrie Sougnez,Manaswi Gupta,Evan Y. Yu,Elahe A. Mostaghel,Heather H. Cheng,Hyojeong Mulcahy,Lawrence D. True,Stephen R. Plymate,Heidi Dvinge,Roberta Ferraldeschi,Penny Flohr,Susana Miranda,Zafeiris Zafeiriou,Nina Tunariu,Joaquin Mateo,Raquel Perez-Lopez,Francesca Demichelis,Brian D. Robinson,Andrea Sboner,Marc H. Schiffman,David M. Nanus,Scott T. Tagawa,Alexandros Sigaras,Kenneth Eng,Olivier Elemento,Elisabeth I. Heath,Howard I. Scher,Kenneth J. Pienta,Philip W. Kantoff,Johann S. de Bono,Mark A. Rubin,Peter S. Nelson,Levi A. Garraway,Charles L. Sawyers,Arul M. Chinnaiyan +72 more
TL;DR: Dan Robinson, Eliezer M. Robinson, Andrea Sboner, Marc Schiffman, David M. Smith, Christine Brennan, Javed Siddiqui, Rohit Mehra, Yu Chen, Dana E. Rathkopf, Michael J. Morris, Stephen B. Solomon, Jeremy C. Tomlins, Kathleen A. Reuter, Anuradha Gopalan, Jianjiong Gao, Massimo Loda, Rosina T.
Journal ArticleDOI
Whole-Exome Sequencing of Metastatic Cancer and Biomarkers of Treatment Response.
Himisha Beltran,Himisha Beltran,Kenneth Eng,Kenneth Eng,Juan Miguel Mosquera,Juan Miguel Mosquera,Alexandros Sigaras,Alessandro Romanel,Hanna Rennert,Myriam Kossai,Myriam Kossai,Chantal Pauli,Chantal Pauli,Bishoy Faltas,Jacqueline Fontugne,Jacqueline Fontugne,Kyung Park,Jason R. Banfelder,Jason R. Banfelder,Davide Prandi,Neel Madhukar,Neel Madhukar,Tuo Zhang,Tuo Zhang,Jessica Padilla,Noah Greco,Terra J. McNary,Erick Herrscher,David Wilkes,Theresa Y. MacDonald,Hui Xue,Vladimir Vacic,Anne-Katrin Emde,Dayna M. Oschwald,Adrian Y. Tan,Zhengming Chen,Colin Collins,Martin E. Gleave,Yuzhuo Wang,Dimple Chakravarty,Marc H. Schiffman,Robert Kim,Robert Kim,Fabien Campagne,Brian D. Robinson,Brian D. Robinson,David M. Nanus,Scott T. Tagawa,Jenny Xiang,Agata Smogorzewska,Francesca Demichelis,Francesca Demichelis,David S. Rickman,David S. Rickman,Andrea Sboner,Andrea Sboner,Olivier Elemento,Olivier Elemento,Mark A. Rubin,Mark A. Rubin +59 more
TL;DR: The majority of advanced, treatment-resistant tumors across tumor types harbor biologically informative alterations, and the establishment of a clinical trial for WES of metastatic tumors with prospective follow-up of patients can help identify candidate predictive biomarkers of response.
Journal ArticleDOI
Deep learning enables robust assessment and selection of human blastocysts after in vitro fertilization.
Pegah Khosravi,Ehsan Kazemi,Qiansheng Zhan,Jonas Malmsten,M. Toschi,Pantelis Zisimopoulos,Alexandros Sigaras,Stuart Lavery,Lee Cooper,Cristina Hickman,Marcos Meseguer,Zev Rosenwaks,Olivier Elemento,Nikica Zaninovic,Iman Hajirasouliha +14 more
TL;DR: An AI-driven approach provides a reproducible way to assess embryo quality and uncovers new, potentially personalized strategies to select embryos.
Journal ArticleDOI
Bone biopsy protocol for advanced prostate cancer in the era of precision medicine.
Verena Sailer,Marc H. Schiffman,Myriam Kossai,Joanna Cyrta,Shaham Beg,Brian L. Sullivan,Bradley B. Pua,Kyungmouk Steve Lee,Adam D. Talenfeld,David M. Nanus,Scott T. Tagawa,Brian D. Robinson,Rema Rao,Chantal Pauli,Rohan Bareja,Luis S Beltran,Alexandros Sigaras,Kenneth Eng,Olivier Elemento,Andrea Sboner,Mark A. Rubin,Himisha Beltran,Juan Miguel Mosquera +22 more
TL;DR: Patients with advanced prostate cancer are undergoing metastatic biopsies to search for actionable targets and/or to identify emerging resistance mechanisms, and obtaining sufficient tissue for clinical and genomic studies is challenging.