P
Patrick Rodriguez
Researcher at Erasmus University Medical Center
Publications - 18
Citations - 2159
Patrick Rodriguez is an academic researcher from Erasmus University Medical Center. The author has contributed to research in topics: Transcription factor & Repressor. The author has an hindex of 18, co-authored 18 publications receiving 2041 citations. Previous affiliations of Patrick Rodriguez include École Polytechnique Fédérale de Lausanne & Erasmus University Rotterdam.
Papers
More filters
Journal ArticleDOI
Efficient biotinylation and single-step purification of tagged transcription factors in mammalian cells and transgenic mice
Ernie de Boer,Patrick Rodriguez,Edgar Bonte,Jeroen Krijgsveld,Eleni Katsantoni,Albert J. R. Heck,Frank Grosveld,John Strouboulis +7 more
TL;DR: BirA-mediated biotinylation of tagged proteins provides the basis for the single-step purification of proteins from mammalian cells, and works efficiently in transgenic mice, raising the prospect of using biOTinylation tagging in protein complex purification directly from animal tissues.
Journal ArticleDOI
GATA‐1 forms distinct activating and repressive complexes in erythroid cells
Patrick Rodriguez,Edgar Bonte,Jeroen Krijgsveld,Katarzyna E. Kolodziej,Boris Guyot,Albert J. R. Heck,Paresh Vyas,Ernie de Boer,Frank Grosveld,John Strouboulis +9 more
TL;DR: It is shown that FOG‐1 mediates GATA‐1 interactions with the MeCP1 complex, thus providing an explanation for the overlapping functions of these two factors in erythropoiesis.
Journal ArticleDOI
Proteomics Analysis of Ring1B/Rnf2 Interactors Identifies a Novel Complex with the Fbxl10/Jhdm1B Histone Demethylase and the Bcl6 Interacting Corepressor
TL;DR: This work identified a novel Ring1B-Fbxl10 complex that also includes Bcl6 corepressor (BcoR), CK2α, Skp1, and Nspc1/Pcgf1 and potentially provides additional mechanisms for chromatin modification/recruitment to chromatin and more evidence for Ring1b/Rnf2 activities beyond those typically associated with PcG function.
Journal ArticleDOI
Histone demethylase KDM5A is an integral part of the core Notch-RBP-J repressor complex
Robert Liefke,Franz Oswald,Cristobal Alvarado,Dolores Ferres-Marco,Gerhard Mittler,Patrick Rodriguez,Maria Dominguez,Tilman Borggrefe +7 more
TL;DR: It is shown that the histone demethylase KDM5A is an integral, conserved component of Notch/RBP-J gene silencing, and interacts physically with RBP-J; this interaction is crucial for Notch-induced growth and tumorigenesis responses.
Journal ArticleDOI
ETO2 coordinates cellular proliferation and differentiation during erythropoiesis
Nicolas Goardon,Julie A. Lambert,Patrick Rodriguez,Philippe Nissaire,Sabine Herblot,Pierre Thibault,Dominique Dumenil,John Strouboulis,Paul-Henri Romeo,Trang Hoang +9 more
TL;DR: The results suggest that the dynamics of ETO2 recruitment within nuclear complexes couple cell proliferation to cell differentiation and determine the onset of terminal erythroid maturation.