P
Patrick Sawa
Researcher at International Centre of Insect Physiology and Ecology
Publications - 29
Citations - 1646
Patrick Sawa is an academic researcher from International Centre of Insect Physiology and Ecology. The author has contributed to research in topics: Gametocyte & Plasmodium falciparum. The author has an hindex of 18, co-authored 29 publications receiving 1423 citations. Previous affiliations of Patrick Sawa include University of Oxford.
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Journal ArticleDOI
Revisiting the circulation time of Plasmodium falciparum gametocytes: molecular detection methods to estimate the duration of gametocyte carriage and the effect of gametocytocidal drugs
Teun Bousema,Teun Bousema,Lucy C Okell,Lucy C Okell,Seif Shekalaghe,Jamie T. Griffin,Sabah A. Omar,Patrick Sawa,Colin J. Sutherland,Robert W. Sauerwein,Azra C. Ghani,Chris Drakeley +11 more
TL;DR: These findings confirm previous estimates of the circulation time of gametocytes, but indicate a much longer duration of (low density) gametocyte carriage after apparently successful clearance of asexual parasites.
Journal ArticleDOI
Examining the human infectious reservoir for Plasmodium falciparum malaria in areas of differing transmission intensity
Bronner P. Gonçalves,Melissa C. Kapulu,Melissa C. Kapulu,Patrick Sawa,Wamdaogo M. Guelbeogo,Alfred B. Tiono,Lynn Grignard,Will Stone,Will Stone,Joel Hellewell,Kjerstin Lanke,Guido J. H. Bastiaens,John S. Bradley,Issa Nebie,Joyce M. Ngoi,Robin Oriango,Dora Mkabili,Maureen Nyaurah,Janet Midega,Janet Midega,Dyann F. Wirth,Kevin Marsh,Kevin Marsh,Thomas S. Churcher,Philip Bejon,Philip Bejon,Sodiomon B. Sirima,Chris Drakeley,Teun Bousema,Teun Bousema +29 more
TL;DR: A multi-regional assessment of population-wide malaria transmission potential based on 1209 mosquito feeding assays in endemic areas of Burkina Faso and Kenya finds that adults transmitted fewer parasites to mosquitoes than children, they received more mosquito bites, thus balancing their contribution to the infectious reservoir.
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The Effect of Dosing Regimens on the Antimalarial Efficacy of Dihydroartemisinin-Piperaquine: A Pooled Analysis of Individual Patient Data
Jane Achan,Ishag Adam,Emmanuel Arinaitwe,Elizabeth A. Ashley,Ghulam Rahim Awab,Ghulam Rahim Awab,Mamadou S. Ba,Karen I. Barnes,Quique Bassat,Steffen Borrmann,Steffen Borrmann,Teun Bousema,Teun Bousema,Prabin Dahal,Umberto D'Alessandro,Umberto D'Alessandro,Timothy M. E. Davis,Arjen M. Dondorp,Grant Dorsey,Chris Drakeley,Caterina I. Fanello,Babacar Faye,Jennifer A. Flegg,Oumar Gaye,Peter W. Gething,Raquel González,Philippe J Guerin,Simon I. Hay,Tran Tinh Hien,Tran Tinh Hien,Bart Janssens,Moses R. Kamya,Corine Karema,Harin Karunajeewa,Moussa Koné,Bertrand Lell,Kevin Marsh,Kevin Marsh,Mayfong Mayxay,Mayfong Mayxay,Clara Menéndez,Petra F. Mens,Martin M Meremikwu,Clarissa Moreira,Clarissa Moreira,Ivo Mueller,Ivo Mueller,Carolyn Nabasumba,Michael Nambozi,Jean Louis Ndiaye,Paul N. Newton,Paul N. Newton,Thuy Nguyen,François Nosten,François Nosten,Christian Nsanzabana,Sabah A. Omar,Jean-Bosco Ouédraogo,Louis K. Penali,Mbaye Pene,Aung Pyae Phyo,Patrice Piola,Ric N. Price,Ric N. Price,P. Sasithon,Philip J. Rosenthal,Albert Same-Ekobo,Patrick Sawa,Henk D. F. H. Schallig,Seif Shekalaghe,Carol Hopkins Sibley,Jeff Smith,Frank Smithuis,Anyirékun Fabrice Somé,Kasia Stepniewska,Ambrose O. Talisuna,Joel Tarning,Joel Tarning,Emiliana Tjitra,Roger Tine,Halidou Tinto,Neena Valecha,Michel Van Herp,Michèle van Vugt,Nicholas J. White,Nicholas J. White,Charles J. Woodrow,William Yavo,Adoke Yeka,Issaka Zongo +89 more
TL;DR: In this paper, the influence of different dosing schedules on Dihydroartemisinin-piperaquine (DP) clinical efficacy was investigated, and a multivariable model was used to identify risk factors for parasite recrudescence.
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Residual Plasmodium falciparum parasitemia in Kenyan children after artemisinin-combination therapy is associated with increased transmission to mosquitoes and parasite recurrence
Khalid B. Beshir,Colin J. Sutherland,Patrick Sawa,Chris Drakeley,Lucy C Okell,Collins K. Mweresa,Sabah A. Omar,Seif Shekalaghe,Harparkash Kaur,Arnold Ndaro,Jaffu Chilongola,Henk D. F. H. Schallig,Robert W. Sauerwein,Rachel Hallett,Teun Bousema +14 more
TL;DR: Residual submicroscopic parasitemia is common after ACT and is associated with a higher transmission potential, and may also have consequences for individual patients because of its higher risk of recurrent Parasitemia.
Journal ArticleDOI
Directional Selection at the pfmdr1, pfcrt, pfubp1, and pfap2mu Loci of Plasmodium falciparum in Kenyan Children Treated With ACT
Gisela Henriques,Rachel Hallett,Khalid B. Beshir,Nahla B Gadalla,Rachel E. Johnson,Rebekah Burrow,Donelly A. van Schalkwyk,Patrick Sawa,Sabah A. Omar,Taane G. Clark,Teun Bousema,Colin J. Sutherland +11 more
TL;DR: Among treated children in western Kenya, certain P. falciparum genotypes defined at pfcrt, pfmdr1, pfap2mu, and pfubp1 more often survive ACT at the submicroscopic level, and contribute to onward transmission and subsequent patent recrudescence.