P
Patrice Piola
Researcher at Pasteur Institute
Publications - 80
Citations - 2752
Patrice Piola is an academic researcher from Pasteur Institute. The author has contributed to research in topics: Malaria & Population. The author has an hindex of 26, co-authored 74 publications receiving 2355 citations. Previous affiliations of Patrice Piola include University of Oxford & Mbarara University of Science and Technology.
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Journal ArticleDOI
Supervised versus unsupervised intake of six-dose artemether-lumefantrine for treatment of acute, uncomplicated Plasmodium falciparum malaria in Mbarara, Uganda: a randomised trial
Patrice Piola,Carole Fogg,Francis Bajunirwe,Samuel Biraro,Francesco Grandesso,Eugene Ruzagira,Joseph B. Babigumira,Isaac Kigozi,James Kiguli,Juliet Kyomuhendo,Laurent Ferradini,Walter R. J. Taylor,Francesco Checchi,Jean Paul Guthmann +13 more
TL;DR: Artemether-lumefantrine has a high cure rate irrespective of whether given under supervision with food or under conditions of routine clinic practice, and could make a substantial contribution to malaria control in Africa.
Journal ArticleDOI
Polymorphisms in Plasmodium falciparum chloroquine Resistance Transporter and Multidrug Resistance 1 Genes: Parasite Risk Factors That Affect Treatment Outcomes for P. falciparum Malaria After Artemether-Lumefantrine and Artesunate-Amodiaquine
Meera Venkatesan,Nahla B Gadalla,Kasia Stepniewska,Prabin Dahal,Christian Nsanzabana,Clarissa Moriera,Ric N. Price,Andreas Mårtensson,Philip J. Rosenthal,Grant Dorsey,Colin J. Sutherland,Philippe J Guerin,Timothy M. E. Davis,Didier Menard,Ishag Adam,George O. Ademowo,Cesar Arze,Frederick N. Baliraine,Nicole Berens-Riha,Anders Björkman,Steffen Borrmann,Francesco Checchi,Meghna Desai,Mehul Dhorda,Abdoulaye Djimde,Badria B. El-Sayed,Teferi Eshetu,Frederick Eyase,Catherine O. Falade,Jean-François Faucher,Gabrielle Fröberg,Anastasia Grivoyannis,Sally Hamour,Sandrine Houzé,Jacob D. Johnson,Erasmus Kamugisha,Simon Kariuki,Jean-René Kiechel,Fred Kironde,Fred Kironde,Poul-Erik Kofoed,Jacques Lebras,Maja Malmberg,Maja Malmberg,Leah Mwai,Leah Mwai,Billy Ngasala,François Nosten,Samuel L. Nsobya,Alexis Nzila,Alexis Nzila,Mary C. Oguike,Sabina Dahlström Otienoburu,Bernhards Ogutu,Jean-Bosco Ouédraogo,Patrice Piola,Patrice Piola,Lars Rombo,Birgit Schramm,A. Fabrice Some,Julie Thwing,Johan Ursing,Rina P. M. Wong,Ahmed Zeynudin,Issaka Zongo,Christopher V. Plowe,Carol Hopkins Sibley,Carol Hopkins Sibley +67 more
TL;DR: Monitoring selection and responding to emerging signs of drug resistance are critical tools for preserving efficacy of artemisinin combination therapies; determination of the prevalence of at least pfcrt K76T and pfmdr1 N86Y should now be routine.
Journal ArticleDOI
Dihydroartemisinin-Piperaquine and Artemether-Lumefantrine for Treating Uncomplicated Malaria in African Children: A Randomised, Non-Inferiority Trial
Quique Bassat,Modest Mulenga,Halidou Tinto,Patrice Piola,Steffen Borrmann,Steffen Borrmann,Clara Menéndez,Clara Menéndez,Michael Nambozi,Innocent Valea,Carolyn Nabasumba,Philip Sasi,Philip Sasi,Antonella Bacchieri,Marco Corsi,David Ubben,Ambrose Talisuna,Umberto D'Alessandro +17 more
TL;DR: DHA-PQP is as efficacious as AL in treating uncomplicated malaria in African children from different endemicity settings, and shows a comparable safety profile.
Journal ArticleDOI
Adherence to a six-dose regimen of artemether-lumefantrine for treatment of uncomplicated plasmodium falciparum malaria in uganda
Carole Fogg,Francis Bajunirwe,Patrice Piola,Samuel Biraro,Francesco Checchi,James Kiguli,Proscovia Namiiro,Joy Musabe,Agnes Kyomugisha,Jean-Paul Guthmann +9 more
TL;DR: The high adherence to artemether-lumefantrine found in this study suggest that this drug is likely to be very effective in Mbarara provided that patients receive clear dosage explanations.
Journal ArticleDOI
The Effect of Dosing Regimens on the Antimalarial Efficacy of Dihydroartemisinin-Piperaquine: A Pooled Analysis of Individual Patient Data
Jane Achan,Ishag Adam,Emmanuel Arinaitwe,Elizabeth A. Ashley,Ghulam Rahim Awab,Ghulam Rahim Awab,Mamadou S. Ba,Karen I. Barnes,Quique Bassat,Steffen Borrmann,Steffen Borrmann,Teun Bousema,Teun Bousema,Prabin Dahal,Umberto D'Alessandro,Umberto D'Alessandro,Timothy M. E. Davis,Arjen M. Dondorp,Grant Dorsey,Chris Drakeley,Caterina I. Fanello,Babacar Faye,Jennifer A. Flegg,Oumar Gaye,Peter W. Gething,Raquel González,Philippe J Guerin,Simon I. Hay,Tran Tinh Hien,Tran Tinh Hien,Bart Janssens,Moses R. Kamya,Corine Karema,Harin Karunajeewa,Moussa Koné,Bertrand Lell,Kevin Marsh,Kevin Marsh,Mayfong Mayxay,Mayfong Mayxay,Clara Menéndez,Petra F. Mens,Martin M Meremikwu,Clarissa Moreira,Clarissa Moreira,Ivo Mueller,Ivo Mueller,Carolyn Nabasumba,Michael Nambozi,Jean Louis Ndiaye,Paul N. Newton,Paul N. Newton,Thuy Nguyen,François Nosten,François Nosten,Christian Nsanzabana,Sabah A. Omar,Jean-Bosco Ouédraogo,Louis K. Penali,Mbaye Pene,Aung Pyae Phyo,Patrice Piola,Ric N. Price,Ric N. Price,P. Sasithon,Philip J. Rosenthal,Albert Same-Ekobo,Patrick Sawa,Henk D. F. H. Schallig,Seif Shekalaghe,Carol Hopkins Sibley,Jeff Smith,Frank Smithuis,Anyirékun Fabrice Somé,Kasia Stepniewska,Ambrose O. Talisuna,Joel Tarning,Joel Tarning,Emiliana Tjitra,Roger Tine,Halidou Tinto,Neena Valecha,Michel Van Herp,Michèle van Vugt,Nicholas J. White,Nicholas J. White,Charles J. Woodrow,William Yavo,Adoke Yeka,Issaka Zongo +89 more
TL;DR: In this paper, the influence of different dosing schedules on Dihydroartemisinin-piperaquine (DP) clinical efficacy was investigated, and a multivariable model was used to identify risk factors for parasite recrudescence.