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Nahla B Gadalla
Researcher at University of London
Publications - 20
Citations - 988
Nahla B Gadalla is an academic researcher from University of London. The author has contributed to research in topics: Plasmodium falciparum & Population. The author has an hindex of 14, co-authored 19 publications receiving 881 citations. Previous affiliations of Nahla B Gadalla include National Institutes of Health.
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Journal ArticleDOI
Polymorphisms in Plasmodium falciparum chloroquine Resistance Transporter and Multidrug Resistance 1 Genes: Parasite Risk Factors That Affect Treatment Outcomes for P. falciparum Malaria After Artemether-Lumefantrine and Artesunate-Amodiaquine
Meera Venkatesan,Nahla B Gadalla,Kasia Stepniewska,Prabin Dahal,Christian Nsanzabana,Clarissa Moriera,Ric N. Price,Andreas Mårtensson,Philip J. Rosenthal,Grant Dorsey,Colin J. Sutherland,Philippe J Guerin,Timothy M. E. Davis,Didier Menard,Ishag Adam,George O. Ademowo,Cesar Arze,Frederick N. Baliraine,Nicole Berens-Riha,Anders Björkman,Steffen Borrmann,Francesco Checchi,Meghna Desai,Mehul Dhorda,Abdoulaye Djimde,Badria B. El-Sayed,Teferi Eshetu,Frederick Eyase,Catherine O. Falade,Jean-François Faucher,Gabrielle Fröberg,Anastasia Grivoyannis,Sally Hamour,Sandrine Houzé,Jacob D. Johnson,Erasmus Kamugisha,Simon Kariuki,Jean-René Kiechel,Fred Kironde,Fred Kironde,Poul-Erik Kofoed,Jacques Lebras,Maja Malmberg,Maja Malmberg,Leah Mwai,Leah Mwai,Billy Ngasala,François Nosten,Samuel L. Nsobya,Alexis Nzila,Alexis Nzila,Mary C. Oguike,Sabina Dahlström Otienoburu,Bernhards Ogutu,Jean-Bosco Ouédraogo,Patrice Piola,Patrice Piola,Lars Rombo,Birgit Schramm,A. Fabrice Some,Julie Thwing,Johan Ursing,Rina P. M. Wong,Ahmed Zeynudin,Issaka Zongo,Christopher V. Plowe,Carol Hopkins Sibley,Carol Hopkins Sibley +67 more
TL;DR: Monitoring selection and responding to emerging signs of drug resistance are critical tools for preserving efficacy of artemisinin combination therapies; determination of the prevalence of at least pfcrt K76T and pfmdr1 N86Y should now be routine.
Journal ArticleDOI
Epidemiology of subpatent Plasmodium falciparum infection: implications for detection of hotspots with imperfect diagnostics
Jacklin F. Mosha,Hugh J. W. Sturrock,Bryan Greenhouse,Brian Greenwood,Colin J. Sutherland,Nahla B Gadalla,Sharanjeet Atwal,Chris Drakeley,Gibson S. Kibiki,Teun Bousema,Teun Bousema,Daniel Chandramohan,Roly Gosling +12 more
TL;DR: In this paper, a cross-sectional survey conducted in north-western Tanzania was used to examine the spatial distribution of Plasmodium falciparum and the relationship between household exposure and parasite density.
Journal ArticleDOI
Directional Selection at the pfmdr1, pfcrt, pfubp1, and pfap2mu Loci of Plasmodium falciparum in Kenyan Children Treated With ACT
Gisela Henriques,Rachel Hallett,Khalid B. Beshir,Nahla B Gadalla,Rachel E. Johnson,Rebekah Burrow,Donelly A. van Schalkwyk,Patrick Sawa,Sabah A. Omar,Taane G. Clark,Teun Bousema,Colin J. Sutherland +11 more
TL;DR: Among treated children in western Kenya, certain P. falciparum genotypes defined at pfcrt, pfmdr1, pfap2mu, and pfubp1 more often survive ACT at the submicroscopic level, and contribute to onward transmission and subsequent patent recrudescence.
Journal ArticleDOI
The effect of dose on the antimalarial efficacy of artemether-lumefantrine: a systematic review and pooled analysis of individual patient data.
Nicholas M. Anstey,Ric N. Price,Tme Davis,Harin Karunajeewa,Ivo Mueller,Umberto D'Alessandro,Achille Massougbodji,Frederic Nikiema,Jean-Bosco Ouédraogo,Halidou Tinto,Issaka Zongo,Albert Same-Ekobo,M Kone,H Menan,AO Toure,William Yavo,Poul-Erik Kofoed,Bereket Alemayehu,Daddi Jima,Elisabeth Baudin,Emmanuelle Espie,Carolyn Nabasumba,Loretxu Pinoges,Birgit Schramm,Michel Cot,Philippe Deloron,Jean-François Faucher,Jean-Paul Guthmann,Bertrand Lell,Steffen Borrmann,George O. Adjei,J Ursing,Emiliana Tjitra,Kevin Marsh,Judy Peshu,Elizabeth Juma,Bernhards Ogutu,Sabah A. Omar,Patrick Sawa,Ambrose O. Talisuna,Maniphone Khanthavong,M Mayxay,Paul N. Newton,Patrice Piola,Abdoulaye Djimde,Ogobara K. Doumbo,Bakary Fofana,Issaka Sagara,Quique Bassat,Raquel González,Clara Menéndez,Frank Smithuis,Teun Bousema,Piet A. Kager,P. F. Mens,Hdfh Schallig,I Van den Broek,M. van Vugt,Maman Laminou Ibrahim,Catherine O. Falade,Martin M Meremikwu,José Pedro Gil,Corine Karema,Ba,Babacar Faye,Oumar Faye,Gaye O,Jean Louis Ndiaye,Mbaye Pene,Doudou Sow,K Sylla,Rck Tine,Louis K. Penali,Karen I. Barnes,Lesley Workman,Angeles Lima,Ishag Adam,Nahla B Gadalla,Efm Malik,Anders Björkman,Andreas Mårtensson,Billy Ngasala,Lars Rombo,P Aliu,Stephan Duparc,Scott G. Filler,Blaise Genton,Eva Maria Hodel,Piero Olliaro,S Abdulla,Erasmus Kamugisha,Zulfiqarali Premji,Seif Shekalaghe,Elizabeth A. Ashley,Verena I. Carrara,Rose McGready,François Nosten,Abul Faiz,Sue J. Lee,Nicholas J. White,Arjen M. Dondorp,Jeff Smith,Joel Tarning,Jane Achan,Hasifa Bukirwa,Adoke Yeka,Emmanuel Arinaitwe,Sarah G. Staedke,Kamya,Fred Kironde,Chris Drakeley,Mary C. Oguike,Colin J. Sutherland,Francesco Checchi,Prabin Dahal,Jennifer A. Flegg,Philippe J Guerin,Clarissa Moreira,Christian Nsanzabana,Carol Hopkins Sibley,Kasia Stepniewska,Peter W. Gething,Si Hay,Brian Greenwood,Stephen A. Ward,P. A. Winstanley,Grant Dorsey,Bryan Greenhouse,P. Rosenthal,Anastasia Grivoyannis,Kamal Hamed,J Hwang,PS Kachur,Michael Nambozi +133 more
TL;DR: The recommended dose of artemether-lumefantrine provides reliable efficacy in most patients with uncomplicated malaria, however, therapeutic efficacy was lowest in young children from Asia and young underweight children from Africa; a higher dose regimen should be assessed in these groups.
Journal ArticleDOI
Increased pfmdr1 copy number and sequence polymorphisms in Plasmodium falciparum isolates from Sudanese malaria patients treated with artemether-lumefantrine
Nahla B Gadalla,Ishag Adam,Salah-Eldin G El-zaki,Sahar Bashir,Izdihar Mukhtar,Mary C. Oguike,Amal A. H. Gadalla,Fathi A Mansour,David C. Warhurst,Badria B. El-Sayed,Colin J. Sutherland +10 more
TL;DR: Molecular markers for surveillance of Plasmodium falciparum resistance to current antimalarials are sorely needed and pfmdr1 gene amplification in parasites prior to treatment occurred in three individuals who had recurrent infection during follow-up.