P
Paul A. Rejto
Researcher at Pfizer
Publications - 87
Citations - 5363
Paul A. Rejto is an academic researcher from Pfizer. The author has contributed to research in topics: Cancer & Docking (molecular). The author has an hindex of 32, co-authored 83 publications receiving 4819 citations. Previous affiliations of Paul A. Rejto include Torrey Pines Institute for Molecular Studies.
Papers
More filters
Journal ArticleDOI
Whole-genome sequencing and comprehensive molecular profiling identify new driver mutations in gastric cancer
Kai Wang,Siu Tsan Yuen,Jiangchun Xu,Siu Po Lee,Helen H.N. Yan,Stephanie T. Shi,Hoi Cheong Siu,Shibing Deng,Kent Man Chu,Simon Law,Kok Hoe Chan,Annie S Y Chan,Wai Yin Tsui,Siu Lun Ho,Anthony K W Chan,Jonathan L K Man,Valentina Foglizzo,Man Kin Ng,April S. Chan,Yick-Pang Ching,Grace H W Cheng,Tao Xie,Julio Fernandez,Vivian S. W. Li,Hans Clevers,Paul A. Rejto,Mao Mao,Suet Yi Leung +27 more
TL;DR: A multidimensional and comprehensive genomic landscape that highlights the molecular complexity of gastric cancer and provides a road map to facilitate genome-guided personalized therapy is illustrated.
Journal ArticleDOI
Molecular recognition of the inhibitor AG-1343 by HIV-1 protease: conformationally flexible docking by evolutionary programming.
Daniel K. Gehlhaar,Gennady M. Verkhivker,Paul A. Rejto,Christopher J. Sherman,David B. Fogel,Lawrence J. Fogel,Stephan T. Freer +6 more
TL;DR: This work sets out to develop a strategy for flexible docking by combining a simple model of ligand-protein interactions for molecular recognition with an evolutionary programming search technique, and develops an intermolecular energy function that incorporates steric and hydrogen-bonding terms.
Journal ArticleDOI
Exome sequencing identifies frequent mutation of ARID1A in molecular subtypes of gastric cancer
Kai Wang,Junsuo Kan,Siu Tsan Yuen,Stephanie T. Shi,Kent Man Chu,Simon Law,Tsun Leung Chan,Zhengyan Kan,Annie S Y Chan,Wai Yin Tsui,Siu Po Lee,Siu Lun Ho,Anthony K W Chan,Grace H W Cheng,Peter Roberts,Paul A. Rejto,Neil W. Gibson,Neil W. Gibson,David Pocalyko,Mao Mao,Jiangchun Xu,Suet Yi Leung +21 more
TL;DR: The mutation spectrum for ARID1A differs between molecular subtypes of gastric cancer, and mutation prevalence is negatively associated with mutations in TP53, and alterations were associated with better prognosis in a stage-independent manner.
Journal ArticleDOI
Whole-genome sequencing identifies recurrent mutations in hepatocellular carcinoma
Zhengyan Kan,Hancheng Zheng,Xiao Liu,Shuyu Li,Thomas D. Barber,Zhuolin Gong,Huan Gao,Ke Hao,Melinda D. Willard,Jiangchun Xu,Robert Hauptschein,Paul A. Rejto,Julio Fernandez,Guan Wang,Qinghui Zhang,Bo Wang,Ronghua Chen,Jian Wang,Nikki P. Lee,Wei Zhou,Zhao Lin,Zhiyu Peng,Kang Yi,Shengpei Chen,Lin Li,Xiaomei Fan,Jie Yang,Rui Ye,Jia Ju,Kai Wang,Heather Estrella,Shibing Deng,Ping Wei,Ming Qiu,Isabella H. Wulur,Jiangang Liu,Mariam Ehsani,Chunsheng Zhang,Andrey Loboda,Wing-Kin Sung,Wing-Kin Sung,Amit Aggarwal,Ronnie T.P. Poon,Sheung Tat Fan,Jun Wang,James S. Hardwick,James S. Hardwick,Christoph Reinhard,Hongyue Dai,Yingrui Li,John M. Luk,John M. Luk,John M. Luk,Mao Mao,Mao Mao +54 more
TL;DR: Findings from a whole-genome sequencing study of 88 matched HCC tumor/normal pairs, 81 of which are Hepatitis B virus (HBV) positive, find beta-catenin to be the mostrequently mutated oncogene and TP53 the most frequently mutated tumor suppressor.
Journal ArticleDOI
Deciphering common failures in molecular docking of ligand-protein complexes.
Gennady M. Verkhivker,Djamal Bouzida,Daniel K. Gehlhaar,Paul A. Rejto,Sandra Arthurs,Anthony B. Colson,Stephan T. Freer,Veda Larson,Brock A. Luty,Tami Marrone,Peter W. Rose +10 more
TL;DR: This protocol resolves some common failures in ligand-protein docking and detects crystallographic binding modes that were not found during docking simulations and proposes a proposed hierarchical approach that involves a hierarchy of energy functions.