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Rui Ye
Researcher at Li Ka Shing Faculty of Medicine, University of Hong Kong
Publications - 17
Citations - 1980
Rui Ye is an academic researcher from Li Ka Shing Faculty of Medicine, University of Hong Kong. The author has contributed to research in topics: Genome-wide association study & Cancer. The author has an hindex of 8, co-authored 14 publications receiving 1758 citations. Previous affiliations of Rui Ye include Beijing Institute of Genomics.
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Journal ArticleDOI
Frequent mutations of chromatin remodeling genes in transitional cell carcinoma of the bladder
Yaoting Gui,Guangwu Guo,Yi Huang,Xueda Hu,Aifa Tang,Aifa Tang,Shengjie Gao,Renhua Wu,Chao Chen,Xianxin Li,Liang Zhou,Minghui He,Zesong Li,Zesong Li,Xiaojuan Sun,Wenlong Jia,Jinnong Chen,Shangming Yang,Fangjian Zhou,Xiaokun Zhao,Shengqing Wan,Rui Ye,Chaozhao Liang,Zhisheng Liu,Peide Huang,Chunxiao Liu,Hui Jiang,Yong Wang,Hancheng Zheng,Liang Sun,Xingwang Liu,Zhimao Jiang,Dafei Feng,Jing Chen,Song Wu,Jing Zou,Zhongfu Zhang,Ruilin Yang,Jun Zhao,Congjie Xu,Weihua Yin,Zhichen Guan,Jiongxian Ye,Hong Zhang,Jingxiang Li,Karsten Kristiansen,Michael L. Nickerson,Dan Theodorescu,Yingrui Li,Xiuqing Zhang,Songgang Li,Jian Wang,Huanming Yang,Jun Wang,Zhiming Cai,Zhiming Cai +55 more
TL;DR: The results provide an overview of the genetic basis of TCC and suggest that aberration of chromatin regulation might be a hallmark of bladder cancer.
Journal ArticleDOI
Whole-genome sequencing identifies recurrent mutations in hepatocellular carcinoma
Zhengyan Kan,Hancheng Zheng,Xiao Liu,Shuyu Li,Thomas D. Barber,Zhuolin Gong,Huan Gao,Ke Hao,Melinda D. Willard,Jiangchun Xu,Robert Hauptschein,Paul A. Rejto,Julio Fernandez,Guan Wang,Qinghui Zhang,Bo Wang,Ronghua Chen,Jian Wang,Nikki P. Lee,Wei Zhou,Zhao Lin,Zhiyu Peng,Kang Yi,Shengpei Chen,Lin Li,Xiaomei Fan,Jie Yang,Rui Ye,Jia Ju,Kai Wang,Heather Estrella,Shibing Deng,Ping Wei,Ming Qiu,Isabella H. Wulur,Jiangang Liu,Mariam Ehsani,Chunsheng Zhang,Andrey Loboda,Wing-Kin Sung,Wing-Kin Sung,Amit Aggarwal,Ronnie T.P. Poon,Sheung Tat Fan,Jun Wang,James S. Hardwick,James S. Hardwick,Christoph Reinhard,Hongyue Dai,Yingrui Li,John M. Luk,John M. Luk,John M. Luk,Mao Mao,Mao Mao +54 more
TL;DR: Findings from a whole-genome sequencing study of 88 matched HCC tumor/normal pairs, 81 of which are Hepatitis B virus (HBV) positive, find beta-catenin to be the mostrequently mutated oncogene and TP53 the most frequently mutated tumor suppressor.
Journal ArticleDOI
Whole-genome and whole-exome sequencing of bladder cancer identifies frequent alterations in genes involved in sister chromatid cohesion and segregation
Guangwu Guo,Xiaojuan Sun,Chao Chen,Song Wu,Peide Huang,Zesong Li,Michael Dean,Yi Huang,Wenlong Jia,Quan Zhou,Aifa Tang,Zuoquan Yang,Xianxin Li,Pengfei Song,Xiaokun Zhao,Rui Ye,Shiqiang Zhang,Zhao Lin,Mingfu Qi,Shengqing Wan,L F Xie,Fan Fan,Michael L. Nickerson,Xiangjun Zou,Xueda Hu,Li Xing,Zhaojie Lv,Hongbin Mei,Shengjie Gao,Chaozhao Liang,Zhibo Gao,Jingxiao Lu,Yuan Yu,Chunxiao Liu,Lin Li,Xiaodong Fang,Zhimao Jiang,Jie Yang,Cailing Li,Xin Zhao,Jing Chen,Fang Zhang,Yongqi Lai,Zheguang Lin,Fangjian Zhou,Hao Chen,Hsiao Chang Chan,Shirley Tsang,Dan Theodorescu,Yingrui Li,Xiuqing Zhang,Jian Wang,Huanming Yang,Yaoting Gui,Jun Wang,Cai Zhiming +55 more
TL;DR: Analysis of TCC by whole-genome and whole-exome sequencing provides evidence that genetic alterations affecting the SCCS process may be involved in bladder tumorigenesis and identifies a new therapeutic possibility for bladder cancer.
Journal ArticleDOI
Frequent mutations of genes encoding ubiquitin-mediated proteolysis pathway components in clear cell renal cell carcinoma
Guangwu Guo,Yaoting Gui,Shengjie Gao,Aifa Tang,Aifa Tang,Xueda Hu,Yi Huang,Yi Huang,Wenlong Jia,Zesong Li,Zesong Li,Minghui He,Liang Sun,Pengfei Song,Xiaojuan Sun,Xiaokun Zhao,Sangming Yang,Chaozhao Liang,Shengqing Wan,Fangjian Zhou,Chao Chen,Jialou Zhu,Xianxin Li,Minghan Jian,Liang Zhou,Rui Ye,Peide Huang,Jing Chen,Tao Jiang,Xiao Liu,Yong Wang,Jing Zou,Zhimao Jiang,Renhua Wu,Song Wu,Fan Fan,Zhongfu Zhang,Lin Liu,Ruilin Yang,Xingwang Liu,Haibo Wu,Weihua Yin,Xia Zhao,Yuchen Liu,Huanhuan Peng,Bing-Hua Jiang,Qingxin Feng,Cailing Li,Jun Xie,Jingxiao Lu,Karsten Kristiansen,Yingrui Li,Xiuqing Zhang,Songgang Li,Jian Wang,Huanming Yang,Zhiming Cai,Zhiming Cai,Jun Wang +58 more
TL;DR: These findings highlight the potential contribution of UMPP to ccRCC tumorigenesis through the activation of the hypoxia regulatory network and detect frequent mutations in the ubiquitin-mediated proteolysis pathway (UMPP).
Journal ArticleDOI
An epigenetic biomarker combination of PCDH17 and POU4F2 detects bladder cancer accurately by methylation analyses of urine sediment DNA in Han Chinese
Yongqiang Wang,Yuan Yu,Rui Ye,Duo Zhang,Qiaoling Li,Dan An,Lu Fang,Youcheng Lin,Yong Hou,Abai Xu,Yu Fu,Wei Lu,Xin Chen,Mingwei Chen,Meng Zhang,Huiling Jiang,Chuanxia Zhang,Pei Dong,Chong Li,Chen Jun,Guosheng Yang,Chunxiao Liu,Zhiming Cai,Fangjian Zhou,Song Wu +24 more
TL;DR: The combination of POU4F2/PCDH17 has yielded the highest sensitivity and specificity in all the 312 individuals, showing the capability of detecting BlCa effectively among pathologically varied sample groups.