S
Shengpei Chen
Researcher at Southeast University
Publications - 33
Citations - 1707
Shengpei Chen is an academic researcher from Southeast University. The author has contributed to research in topics: Massive parallel sequencing & Prenatal diagnosis. The author has an hindex of 17, co-authored 33 publications receiving 1547 citations. Previous affiliations of Shengpei Chen include Beijing Genomics Institute.
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Journal ArticleDOI
Whole-genome sequencing identifies recurrent mutations in hepatocellular carcinoma
Zhengyan Kan,Hancheng Zheng,Xiao Liu,Shuyu Li,Thomas D. Barber,Zhuolin Gong,Huan Gao,Ke Hao,Melinda D. Willard,Jiangchun Xu,Robert Hauptschein,Paul A. Rejto,Julio Fernandez,Guan Wang,Qinghui Zhang,Bo Wang,Ronghua Chen,Jian Wang,Nikki P. Lee,Wei Zhou,Zhao Lin,Zhiyu Peng,Kang Yi,Shengpei Chen,Lin Li,Xiaomei Fan,Jie Yang,Rui Ye,Jia Ju,Kai Wang,Heather Estrella,Shibing Deng,Ping Wei,Ming Qiu,Isabella H. Wulur,Jiangang Liu,Mariam Ehsani,Chunsheng Zhang,Andrey Loboda,Wing-Kin Sung,Wing-Kin Sung,Amit Aggarwal,Ronnie T.P. Poon,Sheung Tat Fan,Jun Wang,James S. Hardwick,James S. Hardwick,Christoph Reinhard,Hongyue Dai,Yingrui Li,John M. Luk,John M. Luk,John M. Luk,Mao Mao,Mao Mao +54 more
TL;DR: Findings from a whole-genome sequencing study of 88 matched HCC tumor/normal pairs, 81 of which are Hepatitis B virus (HBV) positive, find beta-catenin to be the mostrequently mutated oncogene and TP53 the most frequently mutated tumor suppressor.
Journal ArticleDOI
Noninvasive Fetal Trisomy (NIFTY) test: an advanced noninvasive prenatal diagnosis methodology for fetal autosomal and sex chromosomal aneuploidies
Fuman Jiang,Jinghui Ren,Fang-Fang Chen,Yuqiu Zhou,Jiansheng Xie,Shan Dan,Yue Su,Jianhong Xie,Baomin Yin,Wen Su,Huakun Zhang,Wei-wei Wang,Xianghua Chai,Linhua Lin,Hui Guo,Qiyun Li,Peipei Li,Yuying Yuan,Xiaoyu Pan,Yihan Li,Lifu Liu,Huifei Chen,Zhaoling Xuan,Shengpei Chen,Chunlei Zhang,Hongyun Zhang,Zhongming Tian,Zhengyu Zhang,Hui-Hui Jiang,Lijian Zhao,Wei-Mou Zheng,Songgang Li,Yingrui Li,Jun-Jun Wang,Jian Wang,Xiuqing Zhang +35 more
TL;DR: The NIFTY test was more accurate and robust for the detection of both autosomal and sex chromosomal aneuploidies in fetuses and compared with three previously reported z-score approaches with/without GC-bias removal and with internal control.
Journal ArticleDOI
Noninvasive prenatal diagnosis of common fetal chromosomal aneuploidies by maternal plasma DNA sequencing
Tze Kin Lau,Chen Fang,Xiaoyu Pan,Ritsuko K Pooh,Fuman Jiang,Yihan Li,Hui Jiang,Xuchao Li,Shengpei Chen,Xiuqing Zhang +9 more
TL;DR: This massively parallel sequencing-based approach, combined with the improved z-score test methodology, enables the prenatal diagnosis of most common aneuploidies with a high degree of accuracy, even in the first trimester of pregnancy.
Journal ArticleDOI
A method for noninvasive detection of fetal large deletions/duplications by low coverage massively parallel sequencing
Shengpei Chen,Tze Kin Lau,Chunlei Zhang,Chenming Xu,Zhengfeng Xu,Ping Hu,Jian Xu,Hefeng Huang,Ling Pan,Fuman Jiang,Fang Chen,Xiaoyu Pan,Weiwei Xie,Ping Liu,Xuchao Li,Lei Zhang,Songgang Li,Yingrui Li,Xun Xu,Wei Wang,Jun Wang,Hui Jiang,Xiuqing Zhang +22 more
TL;DR: The feasibility of fetal chromosomal deletion/duplication detection using a novel bioinformatic method of low coverage whole genome sequencing of maternal plasma is reported.
Journal ArticleDOI
Massively Parallel Sequencing for Chromosomal Abnormality Testing in Trophectoderm Cells of Human Blastocysts
Xuyang Yin,Ke Tan,Gábor Vajta,Hui Jiang,Yue-Qiu Tan,Chunlei Zhang,Fang Chen,Shengpei Chen,Chunsheng Zhang,Xiaoyu Pan,Chun Gong,Xuchao Li,ChuYu Lin,Ya Gao,Yu Liang,Xin Yi,Feng Mu,Lijian Zhao,Huanhuan Peng,Bo Xiong,Shuoping Zhang,De-Hua Cheng,Guangxiu Lu,Xiuqing Zhang,Ge Lin,Wei Wang +25 more
TL;DR: This study demonstrated MPS could be applied to accurately detect embryonic chromosomal abnormality with a flexible and cost-effective strategy and higher potential accuracy.