P
Paul Blakeley
Researcher at Imperial College London
Publications - 6
Citations - 176
Paul Blakeley is an academic researcher from Imperial College London. The author has contributed to research in topics: Genome-wide association study & Placenta. The author has an hindex of 5, co-authored 6 publications receiving 145 citations.
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Journal ArticleDOI
Maternal prenatal symptoms of depression and down regulation of placental monoamine oxidase A expression
TL;DR: The hypothesis that maternal mood is associated with altered placental function is supported, with a reduction in placental MAO A expression consistent with a subsequent increase in fetal exposure to 5-HT.
Journal ArticleDOI
New alcohol-related genes suggest shared genetic mechanisms with neuropsychiatric disorders
Evangelos Evangelou,Evangelos Evangelou,He Gao,Congying Chu,Georgios Ntritsos,Paul Blakeley,Andrew R. Butts,Raha Pazoki,Hideaki Suzuki,Hideaki Suzuki,Fotios Koskeridis,Andrianos M. Yiorkas,Andrianos M. Yiorkas,Ibrahim Karaman,Joshua Elliott,Qiang Luo,Qiang Luo,Stefanie Aeschbacher,Traci M. Bartz,Sebastian E. Baumeister,Sebastian E. Baumeister,Peter S. Braund,Peter S. Braund,Michael R. Brown,Jennifer A. Brody,Toni-Kim Clarke,Niki Dimou,Jessica D. Faul,Georg Homuth,Anne U. Jackson,Katherine A. Kentistou,Peter K. Joshi,Rozenn N. Lemaitre,Penelope A. Lind,Leo-Pekka Lyytikäinen,Massimo Mangino,Massimo Mangino,Yuri Milaneschi,Christopher P. Nelson,Christopher P. Nelson,Ilja M. Nolte,Mia-Maria Perälä,Ozren Polasek,David J. Porteous,Scott M. Ratliff,Jennifer A. Smith,Alena Stančáková,Alexander Teumer,Samuli Tuominen,Sébastien Thériault,Sébastien Thériault,Jagadish Vangipurapu,John Whitfield,Alexis C. Wood,Jie Yao,Bing Yu,Wei Zhao,Dan E. Arking,Juha Auvinen,Chunyu Liu,Minna Männikkö,Lorenz Risch,Jerome I. Rotter,Harold Snieder,Juha Veijola,Alexandra I. F. Blakemore,Alexandra I. F. Blakemore,Michael Boehnke,Harry Campbell,David Conen,Johan G. Eriksson,Johan G. Eriksson,Hans J. Grabe,Hans J. Grabe,Xiuqing Guo,Pim van der Harst,Catharina A. Hartman,Caroline Hayward,Andrew C. Heath,Marjo-Riitta Järvelin,Marjo-Riitta Järvelin,Marjo-Riitta Järvelin,Mika Kähönen,Sharon L.R. Kardia,Michael Kühne,Johanna Kuusisto,Markku Laakso,Jari Lahti,Terho Lehtimäki,Andrew M. McIntosh,Karen L. Mohlke,Alanna C. Morrison,Nicholas G. Martin,Albertine J. Oldehinkel,Brenda W.J.H. Penninx,Bruce M. Psaty,Bruce M. Psaty,Olli T. Raitakari,Igor Rudan,Nilesh J. Samani,Nilesh J. Samani,Laura J. Scott,Tim D. Spector,Niek Verweij,David R. Weir,James F. Wilson,Daniel Levy,Ioanna Tzoulaki,Jimmy D. Bell,Paul M. Matthews,Adrian Rothenfluh,Sylvane Desrivières,Gunter Schumann,Gunter Schumann,Paul Elliott +114 more
TL;DR: This article conducted a meta-analysis of genome-wide association studies of alcohol consumption from the UK Biobank, the Alcohol Genome Wide Consortium and the Cohorts for Heart and Aging Research in Genomic Epidemiology Plus consortia, collecting data from 480,842 people of European descent to decipher the genetic architecture of alcohol intake.
New alcohol-related genes suggest shared genetic mechanisms with neuropsychiatric disorders
Evangelos Evangelou,He Gao,Congying Chu,Georgios Ntritsos,Paul Blakeley,Andrew R. Butts,Raha Pazoki,Hideaki Suzuki,Fotios Koskeridis,Andrianos M. Yiorkas,Ibrahim Karaman,Joshua Elliott,Qiang Luo,Stefanie Aeschbacher,Traci M. Bartz,Sebastian E. Baumeister,Peter S. Braund,Michael R. Brown,Jennifer A. Brody,Toni-Kim Clarke,Niki Dimou,Jessica D. Faul,Georg Homuth,Anne U. Jackson,Katherine A. Kentistou,Peter K. Joshi,Rozenn N. Lemaitre,Penelope A. Lind,Leo-Pekka Lyytikäinen,Massimo Mangino,Yuri Milaneschi,Christopher P. Nelson,Ilja M. Nolte,Mia-Maria Perälä,Ozren Polasek,David J. Porteous,Scott M. Ratliff,Jennifer A. Smith,Alena Stančáková,Alexander Teumer,Samuli Tuominen,Sébastien Thériault,Jagadish Vangipurapu,John Whitfield,Alexis C. Wood,Jie Yao,Bing Yu,Wei Zhao,Dan E. Arking,Juha Auvinen,Chunyu Liu,Minna Männikkö,Lorenz Risch,Rotter, Jerome, I,Harold Snieder,Juha Veijola,Blakemore, Alexandra, I,Michael Boehnke,Harry Campbell,David Conen,Johan G. Eriksson,Hans J. Grabe,Xiuqing Guo,Pim van der Harst,Catharina A. Hartman,Caroline Hayward,Andrew Heath,Marjo-Riitta Järvelin,Mika Kähönen,Sharon L.R. Kardia,Michael Kühne,Johanna Kuusisto,Maru Laakso,Jari Lahti,Terho Lehtimäki,Andrew M. McIntosh,Karen L. Mohlke,Alanna C. Morrison,Nicholas G. Martin,Albertine J. Oldehinkel,Brenda W.J.H. Penninx,Bruce M. Psaty,T. Raitakari,Igor Rudan,Nilesh J. Samani,Laura J. Scott,Tim D. Spector,Niek Verweij,David R. Weir,James F. Wilson,Daniel Levy,Ioanna Tzoulaki,Jimmy D. Bell,Paul M. Matthews,Adrian Rothenfluh,Sylvane Desrivières,Gunter Schumann,Paul Elliott +97 more
TL;DR: A meta-analysis of genome-wide association studies of alcohol consumption from the UK Biobank, the Alcohol Genome-Wide Consortium and the Cohorts for Heart and Aging Research in Genomic Epidemiology Plus consortia identifies 46 new common loci associated with alcohol consumption and suggests genetic mechanisms that are shared with neuropsychiatric disorders such as schizophrenia.
Journal ArticleDOI
GWAS for urinary sodium and potassium excretion highlights pathways shared with cardiovascular traits
Raha Pazoki,Evangelos Evangelou,Evangelos Evangelou,David Mosen-Ansorena,Rui Pinto,Ibrahim Karaman,Paul Blakeley,Dipender Gill,Verena Zuber,Paul Elliott,Ioanna Tzoulaki,Ioanna Tzoulaki,Abbas Dehghan +12 more
TL;DR: This study highlights pathways that are shared between urinary sodium and potassium excretion and cardiovascular traits and identifies 50 and 13 novel loci, respectively, some of which show a potential causal relationship with blood pressure based on MR analysis.
Posted ContentDOI
Genome-wide association and functional studies identify 46 novel loci for alcohol consumption and suggest common genetic mechanisms with neuropsychiatric disorders
Evangelos Evangelou,Evangelos Evangelou,He Gao,Congying Chu,Georgios Ntritsos,Paul Blakeley,Andrew R. Butts,Raha Pazoki,Hideaki Suzuki,Hideaki Suzuki,Fotios Koskeridis,Andrianos M. Yiorkas,Andrianos M. Yiorkas,Ibrahim Karaman,Joshua Elliott,Stefanie Aeschbacher,Traci M. Bartz,Sebastian E. Baumeister,Sebastian E. Baumeister,Peter S. Braund,Peter S. Braund,Michael R. Brown,Jennifer A. Brody,Toni-Kim Clarke,Niki Dimou,Jessica D. Faul,Georg Homuth,Anne U. Jackson,Katherine A. Kentistou,Peter K. Joshi,Rozenn N. Lemaitre,Penelope A. Lind,Leo-Pekka Lyytikäinen,Massimo Mangino,Massimo Mangino,Yuri Milaneschi,Christopher P. Nelson,Christopher P. Nelson,Ilja M. Nolte,Mia-Maria Perälä,Ozren Polasek,David J. Porteous,Scott M. Ratliff,Jennifer A. Smith,Alena Stančáková,Alexander Teumer,Samuli Tuominen,Sébastien Thériault,Sébastien Thériault,Jagadish Vangipurapu,John Whitfield,Alexis C. Wood,Jie Yao,Bing Yu,Wei Zhao,Dan E. Arking,Juha Auvinen,Chunyu Liu,Minna Männikkö,Lorenz Risch,Jerome I. Rotter,Harold Snieder,Juha Veijola,Alexandra I. F. Blakemore,Alexandra I. F. Blakemore,Michael Boehnke,Harry Campbell,David Conen,Johan G. Eriksson,Hans J. Grabe,Hans J. Grabe,Xiuqing Guo,Pim van der Harst,Catharina A. Hartman,Caroline Hayward,Andrew C. Heath,Marjo-Riitta Järvelin,Marjo-Riitta Järvelin,Mika Kähönen,Sharon L.R. Kardia,Michael Kühne,Johanna Kuusisto,Markku Laakso,Jari Lahti,Terho Lehtimäki,Andrew M. McIntosh,Karen L. Mohlke,Alanna C. Morrison,Nicholas G. Martin,Albertine J. Oldehinkel,Brenda W.J.H. Penninx,Bruce M. Psaty,Bruce M. Psaty,Olli T. Raitakari,Igor Rudan,Nilesh J. Samani,Nilesh J. Samani,Laura J. Scott,Tim D. Spector,Niek Verweij,David R. Weir,James F. Wilson,Daniel Levy,Ioanna Tzoulaki,Jimmy D. Bell,Paul M. Matthews,Adrian Rothenfluh,Sylvane Desrivières,Gunter Schumann,Paul Elliott,Paul Elliott +110 more
TL;DR: A genome-wide association study of alcohol use in ~480,000 people of European descent to decipher the genetic architecture of alcohol intake identified 46 novel, common loci and investigated their potential functional significance using magnetic resonance imaging data, gene expression and behavioral studies in Drosophila.