Pawel Botwina

TL;DR: The antiviral activity of an HTCC compound, previously developed by us, is described, which may be used as a potential inhibitor of currently circulating highly pathogenic coronaviruses—SARS- coV-2 and MERS-CoV.

TL;DR: In this article, the effect of organoselenium functionalities in the C-8 seleno-quercetin derivatives was explored, and it was shown that a hydrogen bond between the selenium atom and Gln189 residue in the catalytic pocket could explain the higher Mpro activity of 2d and, as a result, its better antiviral profile.

TL;DR: In this article, N-palmitoyl-N-monomethyl-N,N, N-dimethyl-N and N-trimethyl-6-O-glycolchitosan (GCPQ), a positively charged polymer that has been through an extensive Good Laboratory Practice toxicology screen, is able to reduce the infectivity of SARS-COV-2 in A549ACE2+ and Vero E6 cells with a log removal value of − 3 to − 4 at a concentration of 10-100μg/

TL;DR: Cell-type-dependent anti-influenza properties of BBR in vitro suggest that the compound acts on the cell and not the virus, and hampers influenza A replication in primary human airway epithelium 3D cultures that mimic the natural replication site of the virus.

TL;DR: A dose dependent inhibition of hMPV infection by NSPAHs in LLC-MK2 cells is shown and it is suggested that observed antiviral effect depend on selective inhibition of viruses budding from the cell surface.