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Irene Homminga
Researcher at Boston Children's Hospital
Publications - 13
Citations - 1008
Irene Homminga is an academic researcher from Boston Children's Hospital. The author has contributed to research in topics: Internal medicine & Gene expression profiling. The author has an hindex of 8, co-authored 11 publications receiving 933 citations. Previous affiliations of Irene Homminga include Erasmus University Rotterdam.
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Journal ArticleDOI
γ-secretase inhibitors reverse glucocorticoid resistance in T cell acute lymphoblastic leukemia
Pedro J. Real,Valeria Tosello,Teresa Palomero,Teresa Palomero,Mireia Castillo,Eva Hernando,Elisa de Stanchina,Maria Luisa Sulis,Maria Luisa Sulis,Kelly Barnes,Catherine M. Sawai,Irene Homminga,Jules P.P. Meijerink,Iannis Aifantis,Giuseppe Basso,Carlos Cordon-Cardo,Weiyun Z. Ai,Adolfo A. Ferrando,Adolfo A. Ferrando +18 more
TL;DR: It is shown that combination therapy with GSIs plus glucocorticoids can improve the antileukemic effects of GSIs and reduce their gut toxicity in vivo and support a role for glucocORTicoid-resistant T-ALL.
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Integrated Transcript and Genome Analyses Reveal NKX2-1 and MEF2C as Potential Oncogenes in T Cell Acute Lymphoblastic Leukemia
Irene Homminga,Rob Pieters,Anton W. Langerak,Johan J. de Rooi,Andrew P. Stubbs,Monique Verstegen,Maartje Vuerhard,Jessica Buijs-Gladdines,Clarissa Kooi,Petra Klous,Petra Klous,Pieter Van Vlierberghe,Adolfo A. Ferrando,Jean Michel Cayuela,Brenda Verhaaf,H. Berna Beverloo,Martin A. Horstmann,Valerie de Haas,Anna-Sophia Wiekmeijer,Karin Pike-Overzet,Frank J. T. Staal,Wouter de Laat,Wouter de Laat,Jean Soulier,François Sigaux,Jules P.P. Meijerink +25 more
TL;DR: NKX2-1, NKX22-2, and MEF2C are proposed as T-ALL oncogenes that are activated by various rearrangements.
Journal ArticleDOI
High-resolution identification of balanced and complex chromosomal rearrangements by 4C technology
Marieke Simonis,Petra Klous,Petra Klous,Irene Homminga,Robert-Jan H. Galjaard,Erikjan Rijkers,Frank Grosveld,Jules P.P. Meijerink,Wouter de Laat,Wouter de Laat +9 more
TL;DR: It is demonstrated that chromatin conformation capture on chip (4C) technology can be used to screen large genomic regions for balanced and complex inversions and translocations at high resolution and opens avenues for the rapid fine-mapping of cytogenetically identified translocations and inversions.
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NKL homeobox genes in leukemia
TL;DR: It is hypothesized that the NKL genes might share a similar downstream effect that promotes leukemogenesis, possibly due to mimicking a NKL gene that has a physiological role in early hematopoietic development, such as HHEX.
Journal ArticleDOI
In vitro efficacy of forodesine and nelarabine (ara-G) in pediatric leukemia
Irene Homminga,C. Michel Zwaan,Chantal Y. Manz,Cynthia Parker,Shanta Bantia,Willem K. Smits,Fiona Higginbotham,Rob Pieters,Jules P.P. Meijerink +8 more
TL;DR: Forodesine and ara-G cytotoxicities were higher in T-cell acute lymphoblastic leukemia (T-ALL) samples than in B-cell precursor (BCP)-ALL and acute myeloid leukemia (AML) samples, suggesting that especially T-ALL, but also BCP-all, pediatric patients may benefit from forodesine or nelarabine (ara-G) treatment.