Petter Brodin

TL;DR: A means by which individuals at highest risk of life-threatening COVID-19 can be identified is identified, and the hypothesis that neutralizing auto-Abs against type I IFNs may underlie critical CO VID-19 is tested.

TL;DR: A systems-level analysis of 210 healthy twins between 8 and 82 years of age found that 77% of parameters, including cell population frequencies, cytokine responses, and serum proteins, are dominated by non-heritable influences, and in MZ twins discordant for cytomegalovirus infection, more than half of all parameters are affected.

TL;DR: The inflammatory response in MIS-C differs from the cytokine storm of severe acute COVID-19, shares several features with Kawasaki disease, but also differs from this condition with respect to T cell subsets, interleukin (IL)-17A, and biomarkers associated with arterial damage.

TL;DR: The human immune system is highly variable between individuals but relatively stable over time within a given person, but symbiotic and pathogenic microbes and other non-heritable influences explain most of this variation.

TL;DR: This article performed longitudinal analyses in 100 newborn children, sampled up to 4 times during their first 3 months of life, and analyzed the development of 58 immune cell populations by mass cytometry and 267 plasma proteins by immunoassays.