P
Peng Yu
Researcher at Texas A&M University
Publications - 73
Citations - 2378
Peng Yu is an academic researcher from Texas A&M University. The author has contributed to research in topics: Alternative splicing & RNA splicing. The author has an hindex of 19, co-authored 69 publications receiving 2047 citations. Previous affiliations of Peng Yu include Texas Tech University & Texas A&M Health Science Center College of Medicine.
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Journal ArticleDOI
A SUMOylation-dependent transcriptional subprogram is required for Myc-driven tumorigenesis.
Jessica D. Kessler,Kristopher T. Kahle,Kristopher T. Kahle,Tingting Sun,Kristen L. Meerbrey,Michael R. Schlabach,Earlene M. Schmitt,Samuel O. Skinner,Samuel O. Skinner,Qikai Xu,Mamie Z. Li,Zachary C. Hartman,Mitchell Rao,Peng Yu,Rocio Dominguez-Vidana,Anthony C. Liang,Nicole L. Solimini,Ronald J. Bernardi,Bing Yu,Tiffany Y.T. Hsu,Ido Golding,Ido Golding,Ji Luo,C. Kent Osborne,Chad J. Creighton,Susan G. Hilsenbeck,Rachel Schiff,Chad A. Shaw,Stephen J. Elledge,Thomas F. Westbrook +29 more
TL;DR: A genome-wide RNA interference screen was used to search for Myc–synthetic lethal genes and uncovered a role for the SUMO-activating enzyme (SAE1/2), which catalyzes a posttranslational modification (SUMOylation) that alters protein behavior and function.
Journal ArticleDOI
SHANK3 overexpression causes manic-like behaviour with unique pharmacogenetic properties
Kihoon Han,Kihoon Han,J. Lloyd Holder,J. Lloyd Holder,Christian P. Schaaf,Christian P. Schaaf,Hui Lu,Hui Lu,Hongmei Chen,Hongmei Chen,Hyojin Kang,Hyojin Kang,Hyojin Kang,Jianrong Tang,Jianrong Tang,Zhenyu Wu,Zhenyu Wu,Shuang Hao,Shuang Hao,Sau Wai Cheung,Peng Yu,Peng Yu,Hao Sun,Hao Sun,Amy M. Breman,Ankita Patel,Hui-Chen Lu,Huda Y. Zoghbi +27 more
TL;DR: This article found that incorrect gene dosage of SHANK3 (a gene linked to some human neuropsychiatric disorders, including autism spectrum disorder) is associated with behavioural abnormalities including mania, possibly because of actin regulation problems in excitatory/inhibitory synapses.
Journal ArticleDOI
An AT-Hook Domain in MeCP2 Determines the Clinical Course of Rett Syndrome and Related Disorders
Steven Andrew Baker,Lin Chen,Angela D. Wilkins,Peng Yu,Olivier Lichtarge,Olivier Lichtarge,Huda Y. Zoghbi +6 more
TL;DR: It is discovered that MeCP2 contains three AT-hook-like domains over a stretch of 250 amino acids, like HMGA DNA-bending proteins; one conserved AT- hook is disrupted in MeCP1-R270X, lending further support to the notion that one of Me CP2's key functions is to alter chromatin structure.
Journal ArticleDOI
Exercise and Genetic Rescue of SCA1 via the Transcriptional Repressor Capicua
John D. Fryer,Peng Yu,Hyojin Kang,Caleigh Mandel-Brehm,Angela N. Carter,Juan Crespo-Barreto,Yan Gao,Adriano Flora,Chad A. Shaw,Harry T. Orr,Huda Y. Zoghbi +10 more
TL;DR: A mild exercise regimen in a mouse model of SCA1 found a considerable improvement in survival accompanied by up-regulation of epidermal growth factor and consequential down- regulation of Capicua, which is an ATXN1 interactor, which might have long-term beneficial effects in other ataxias and neurodegenerative diseases.
Journal ArticleDOI
True process variation aware optical proximity correction with variational lithography modeling and model calibration
Peng Yu,Sean X. Shi,David Z. Pan +2 more
TL;DR: This work derives a variational lithography model (VLIM) that can simulate across the process window without much run-time overhead compared to the conventional lithography models, and introduces the variational edge placement error (VEPE) metrics based on the model.