M
Markku Saraheimo
Researcher at University of Helsinki
Publications - 72
Citations - 4586
Markku Saraheimo is an academic researcher from University of Helsinki. The author has contributed to research in topics: Type 1 diabetes & Diabetes mellitus. The author has an hindex of 35, co-authored 72 publications receiving 4140 citations. Previous affiliations of Markku Saraheimo include Helsinki University Central Hospital.
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Journal ArticleDOI
The Presence and Severity of Chronic Kidney Disease Predicts All-Cause Mortality in Type 1 Diabetes
Per-Henrik Groop,Per-Henrik Groop,Merlin C. Thomas,John Moran,Johan Wadén,Johan Wadén,Lena M. Thorn,Lena M. Thorn,Ville-Petteri Mäkinen,Ville-Petteri Mäkinen,Milla Rosengård-Bärlund,Milla Rosengård-Bärlund,Markku Saraheimo,Markku Saraheimo,Kustaa Hietala,Kustaa Hietala,Outi Heikkilä,Outi Heikkilä,Carol Forsblom,Carol Forsblom +19 more
TL;DR: An independent graded association was observed between the presence and severity of kidney disease and mortality in a large contemporary cohort of individuals with type 1 diabetes, highlighting the clinical and public health importance of chronic kidney diseaseand its prevention in the management of type 2 diabetes.
Journal ArticleDOI
Metabolic Syndrome in Type 1 Diabetes: Association with diabetic nephropathy and glycemic control (the FinnDiane study)
Lena M. Thorn,Lena M. Thorn,Carol Forsblom,Carol Forsblom,J. Fagerudd,J. Fagerudd,Merlin C. Thomas,K. Pettersson-Fernholm,K. Pettersson-Fernholm,Markku Saraheimo,Markku Saraheimo,Johan Wadén,Johan Wadén,Mats Rönnback,Mats Rönnback,Milla Rosengård-Bärlund,Milla Rosengård-Bärlund,Clas Göran af Björkesten,Clas Göran af Björkesten,Marja-Riitta Taskinen,Per-Henrik Groop,Per-Henrik Groop +21 more
TL;DR: The metabolic syndrome is a frequent finding in type 1 diabetes and increases with advanced diabetic nephropathy and worse glycemic control, and also increased with worsening creatinine clearance.
Journal ArticleDOI
The Association Between Dietary Sodium Intake, ESRD, and All-Cause Mortality in Patients With Type 1 Diabetes
Merlin C. Thomas,John Moran,Carol Forsblom,Carol Forsblom,Valma Harjutsalo,Lena M. Thorn,Lena M. Thorn,Aila J. Ahola,Johan Wadén,Johan Wadén,Nina Tolonen,Nina Tolonen,Markku Saraheimo,Markku Saraheimo,Daniel Gordin,Daniel Gordin,Per-Henrik Groop,Per-Henrik Groop +17 more
TL;DR: In patients with type 1 diabetes, sodium was independently associated with all-cause mortality and ESRD, and these findings support the calls for caution before applying salt restriction universally.
Journal ArticleDOI
Diabetic nephropathy is associated with low-grade inflammation in Type 1 diabetic patients
Markku Saraheimo,A.-M. Teppo,Carol Forsblom,Carol Forsblom,J. Fagerudd,J. Fagerudd,Per-Henrik Groop,Per-Henrik Groop +7 more
TL;DR: Low-grade inflammatory markers are associated with diabetic nephropathy in Type 1 diabetic patients and the predictive value needs to be assessed.
Journal ArticleDOI
New susceptibility loci associated with kidney disease in type 1 diabetes.
Niina Sandholm,Niina Sandholm,Rany M. Salem,Rany M. Salem,Amy Jayne McKnight,Eoin P. Brennan,Carol Forsblom,Tamara Isakova,Gareth J. McKay,Winfred W. Williams,Denise M. Sadlier,Ville-Petteri Mäkinen,Ville-Petteri Mäkinen,Elizabeth Swan,Cameron D. Palmer,Cameron D. Palmer,Andrew P. Boright,Emma Ahlqvist,Harshal Deshmukh,Benjamin J. Keller,Huateng Huang,Aila J. Ahola,Emma Fagerholm,Daniel Gordin,Valma Harjutsalo,Valma Harjutsalo,Bing He,Outi Heikkilä,Kustaa Hietala,Janne P. Kytö,Päivi Lahermo,Markku Lehto,Raija Lithovius,Anne-May Österholm,Maija Parkkonen,Janne Pitkäniemi,Milla Rosengård-Bärlund,Markku Saraheimo,Cinzia Sarti,Jenny Söderlund,Aino Soro-Paavonen,Anna Syreeni,Lena M. Thorn,Heikki O. Tikkanen,Nina Tolonen,Karl Tryggvason,Jaakko Tuomilehto,Johan Wadén,Geoffrey V. Gill,Sarah L. Prior,Candace Guiducci,Daniel B. Mirel,Andrew M. Taylor,Andrew M. Taylor,S. Mohsen Hosseini,Hans-Henrik Parving,Hans-Henrik Parving,Peter Rossing,Peter Rossing,Lise Tarnow,Lise Tarnow,Claes Ladenvall,François Alhenc-Gelas,Pierre Lefebvre,Vincent Rigalleau,Ronan Roussel,David-Alexandre Trégouët,Anna Maestroni,Silvia Maestroni,Henrik Falhammar,Tianwei Gu,Anna Möllsten,D. Cimponeriu,Mihai Ioana,Maria Mota,Eugen Mota,Cristian Serafinceanu,Monica Stavarachi,Robert L. Hanson,Robert G. Nelson,Matthias Kretzler,Helen M. Colhoun,Nicolae Mircea Panduru,Harvest F. Gu,Kerstin Brismar,Gianpaolo Zerbini,Samy Hadjadj,Michel Marre,Michel Marre,Leif Groop,Maria Lajer,Shelley B. Bull,Daryl Waggott,Andrew D. Paterson,David A. Savage,Stephen C. Bain,Finian Martin,Joel N. Hirschhorn,Joel N. Hirschhorn,Catherine Godson,Jose C. Florez,Jose C. Florez,Per-Henrik Groop,Per-Henrik Groop,Alexander P. Maxwell,Alexander P. Maxwell +105 more
TL;DR: A meta-analysis of genome-wide association studies of T1D DN revealed association of two SNPs with ESRD in the AFF3 gene and an intergenic SNP on chromosome 15q26 between the genes RGMA and MCTP2, which represent new signals in the pathogenesis of DN.