P
Per-Olof Bergh
Researcher at University of Gothenburg
Publications - 10
Citations - 589
Per-Olof Bergh is an academic researcher from University of Gothenburg. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 3, co-authored 5 publications receiving 265 citations. Previous affiliations of Per-Olof Bergh include Sahlgrenska University Hospital.
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Journal ArticleDOI
Microbially Produced Imidazole Propionate Impairs Insulin Signaling through mTORC1.
Ara Koh,Antonio Molinaro,Marcus Ståhlman,Muhammad Tanweer Khan,Caroline Schmidt,Louise Mannerås-Holm,Hao Wu,Alba Carreras,Heeyoon Jeong,Louise E. Olofsson,Per-Olof Bergh,Victor E. A. Gerdes,Annick V. Hartstra,Maurits de Brauw,Rosie Perkins,Max Nieuwdorp,Max Nieuwdorp,Max Nieuwdorp,Göran Bergström,Fredrik Bäckhed,Fredrik Bäckhed +20 more
TL;DR: It is shown that imidazole propionate is produced from histidine in a gut simulator at higher concentrations when using fecal microbiota from subjects with versus without type 2 diabetes and that it impairs glucose tolerance when administered to mice.
Journal ArticleDOI
Imidazole propionate is increased in diabetes and associated with dietary patterns and altered microbial ecology
Antonio Molinaro,Antonio Molinaro,Pierre Bel Lassen,Marcus Henricsson,Hao Wu,Solia Adriouch,Eugeni Belda,Rima Chakaroun,Trine Nielsen,Per-Olof Bergh,Christine Rouault,Sébastien André,Florian Marquet,Fabrizio Andreelli,Joe-Elie Salem,Karen E. Assmann,Jean-Philippe Bastard,Sofia K. Forslund,Gwen Falony,Nicolas Pons,Edi Prifti,Benoit Quinquis,Hugo Roume,Sara Vieira-Silva,Tue H. Hansen,Helle Krogh Pedersen,Christian Lewinter,Nadja B Sønderskov,Lars Køber,Henrik Vestergaard,Torben Hansen,Jean-Daniel Zucker,Pilar Galan,Marc-Emmanuel Dumas,Marc-Emmanuel Dumas,Jeroen Raes,Jeroen Raes,Jean-Michel Oppert,Ivica Letunic,Jens Nielsen,Peer Bork,S. Dusko Ehrlich,Michael Stumvoll,Oluf Pedersen,Judith Aron-Wisnewsky,Karine Clément,Karine Clément,Fredrik Bäckhed,Fredrik Bäckhed,Fredrik Bäckhed +49 more
TL;DR: The microbiota may contribute to type 2 diabetes by generating imidazole propionate that can modulate host inflammation and metabolism, which likely reflects altered microbial metabolism of histidine, rather than histidine intake per se.
Journal ArticleDOI
6α-hydroxylated bile acids mediate TGR5 signalling to improve glucose metabolism upon dietary fiber supplementation in mice
Kassem M. Makki,Harald Brolin,Natalia Petersen,Marcus Henricsson,Dan Ploug Christensen,Muhammad Tanweer Khan,Annika Wahlström,Per-Olof Bergh,Valentina Tremaroli,Kristina Schoonjans,Hanns-Ulrich Marschall,Fredrik Bäckhed +11 more
TL;DR: Modulation of the gut microbiota with oligofructose enriches bacteria involved in 6α-hydroxylated bile acid production and leads to TGR5-GLP1R axis activation to improve body weight and metabolism under western-style diet feeding in mice.
Journal ArticleDOI
Duodenal Anaerobutyricum soehngenii infusion stimulates GLP-1 production, ameliorates glycaemic control and beneficially shapes the duodenal transcriptome in metabolic syndrome subjects: a randomised double-blind placebo-controlled cross-over study.
Annefleur M. Koopen,Julia J. Witjes,Koen Wortelboer,Soumia Majait,Andrei Prodan,Evgeni Levin,Hilde Herrema,Maaike Winkelmeijer,Steven Aalvink,Jacques J. Bergman,Stephan Havik,Bolette Hartmann,Han Levels,Per-Olof Bergh,Jamie van Son,Manon Balvers,Diogo Mendes Bastos,Erik S.G. Stroes,Albert K. Groen,Marcus Henricsson,Ellis Marleen Kemper,Jens J. Holst,Christopher M. Strauch,Christopher M. Strauch,Stanley L. Hazen,Stanley L. Hazen,Fredrik Bäckhed,Willem M. de Vos,Max Nieuwdorp,Elena Rampanelli +29 more
TL;DR: In this paper, the authors investigated the potential therapeutic effects of A. soehngenii L2-7 on systemic metabolic responses and duodenal transcriptome profiles in individuals with metabolic syndrome.
Journal ArticleDOI
Antioxidants Promote Intestinal Tumor Progression in Mice.
Zhiyuan V. Zou,Kristell Le Gal,Ahmed E. El Zowalaty,Lara E. Pehlivanoglu,Viktor Garellick,Nadia Gul,Mohamed X. Ibrahim,Per-Olof Bergh,Marcus Henricsson,Clotilde Wiel,Levent M. Akyürek,Martin O. Bergo,Volkan I. Sayin,Per Lindahl +13 more
TL;DR: In this article, N-acetylcysteine (NAC) and vitamin E (VE) supplements were shown to increase tumor growth in early neoplasias and tumor grades in more advanced lesions without any impact on tumor initiation.