P
Peter Askjaer
Researcher at Pablo de Olavide University
Publications - 70
Citations - 3766
Peter Askjaer is an academic researcher from Pablo de Olavide University. The author has contributed to research in topics: Caenorhabditis elegans & Chromatin. The author has an hindex of 26, co-authored 61 publications receiving 3244 citations. Previous affiliations of Peter Askjaer include Spanish National Research Council & Aarhus University.
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Journal ArticleDOI
Step-wise methylation of histone H3K9 positions heterochromatin at the nuclear periphery.
Benjamin D. Towbin,Cristina González-Aguilera,Ragna Sack,Dimos Gaidatzis,Véronique Kalck,Peter Meister,Peter Askjaer,Susan M. Gasser,Susan M. Gasser +8 more
TL;DR: Analysis of histone methyltransferases showed that elimination of two HMTs, MET-2 and SET-25, mimics the loss of SAM synthetase, abrogating the perinuclear attachment of heterochromatic transgenes and of native chromosomal arms rich in histone H3 lysine 9 methylation.
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MEL-28/ELYS is required for the recruitment of nucleoporins to chromatin and postmitotic nuclear pore complex assembly
Cerstin Franz,Rudolf Walczak,Sevil Yavuz,Rachel Santarella,Marc Gentzel,Peter Askjaer,Vincent Galy,Martin W. Hetzer,Iain W. Mattaj,Wolfram Antonin +9 more
TL;DR: Using in vitro NE assembly, it is shown that the vertebrate homologue of MEL‐28 (maternal effect lethal), a recently discovered NE component in Caenorhabditis elegans, functions in postmitotic NPC assembly and is suggested that M EL‐28 acts as a seeding point for NPC assembly.
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The Specificity of the CRM1-Rev Nuclear Export Signal Interaction Is Mediated by RanGTP*
TL;DR: The data are consistent with a model in which CRM1 is the nuclear export receptor for the Rev-RRE ribonucleoprotein complex and that RanGTP binds to a preformed Rev-CRM1 complex and specifies a functional interaction with the NES.
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RanGTP-regulated interactions of CRM1 with nucleoporins and a shuttling DEAD-box helicase.
Peter Askjaer,Angela Bachi,Matthias Wilm,F. Ralf Bischoff,Daniel L. Weeks,Vera M Ogniewski,Mutsuhito Ohno,Christof Niehrs,Jørgen Kjems,Iain W. Mattaj,Maarten Fornerod +10 more
TL;DR: Using a quantitativeCRM1-NES cargo binding assay, significant differences in affinity for CRM1 among natural NESs are demonstrated, suggesting that the steady-state nucleocytoplasmic distribution of shuttling proteins could be determined by the relative strengths of their NESs.
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RanGTP mediates nuclear pore complex assembly
Tobias C. Walther,Peter Askjaer,Marc Gentzel,Anja Habermann,Gareth Griffiths,Matthias Wilm,Iain W. Mattaj,Martin W. Hetzer +7 more
TL;DR: RanGTP production is required to dissociate nucleoporins Nup107, Nup153 and Nup358 from Importin β, to target them to chromatin and to induce association between separate NPC subcomplexes, and a mechanism for the spatial restriction of NPC assembly to the surface of chromatin is suggested.