P
Peter T. Donaldson
Researcher at Newcastle University
Publications - 30
Citations - 3507
Peter T. Donaldson is an academic researcher from Newcastle University. The author has contributed to research in topics: Single-nucleotide polymorphism & Primary biliary cirrhosis. The author has an hindex of 20, co-authored 30 publications receiving 3242 citations.
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Journal ArticleDOI
HLA-B*5701 genotype is a major determinant of drug-induced liver injury due to flucloxacillin.
Ann K. Daly,Peter T. Donaldson,Pallav Bhatnagar,Yufeng Shen,Itsik Pe'er,Aris Floratos,Mark J. Daly,David Goldstein,Sally John,Matthew R. Nelson,Julia Graham,B. Kevin Park,John F. Dillon,William Bernal,Heather J. Cordell,Munir Pirmohamed,Guruprasad P. Aithal,Christopher P. Day +17 more
TL;DR: Findings provide new insights into the mechanism of flucloxacillin DILI and have the potential to substantially improve diagnosis of this serious disease.
Journal ArticleDOI
TM6SF2 rs58542926 influences hepatic fibrosis progression in patients with non-alcoholic fatty liver disease
Yang-Lin Liu,Helen L. Reeves,Alastair D. Burt,Dina Tiniakos,Stuart McPherson,Julian B. S. Leathart,Michael Allison,Graeme J.M. Alexander,Anne Christine Piguet,Rodolphe Anty,Peter T. Donaldson,Guruprasad P. Aithal,Sven Francque,Luc Van Gaal,Karine Clément,Vlad Ratziu,Jean-François Dufour,Christopher P. Day,Ann K. Daly,Quentin M. Anstee +19 more
TL;DR: It is confirmed that TM6SF2 minor allele carriage is associated with NAFLD and is causally related to a previously reported chromosome 19 GWAS signal that was ascribed to the gene NCAN.
Journal ArticleDOI
Genome-wide association study identifies 12 new susceptibility loci for primary biliary cirrhosis
George F. Mells,James A B Floyd,Katherine I. Morley,Katherine I. Morley,Heather J. Cordell,Christopher S. Franklin,So-Youn Shin,Michael A. Heneghan,James Neuberger,Peter T. Donaldson,Darren B. Day,Samantha J. Ducker,Agnes Muriithi,Elizabeth F Wheater,Christopher J Hammond,Muhammad F. Dawwas,David Jones,Leena Peltonen,Graeme J.M. Alexander,Richard Sandford,Carl A. Anderson +20 more
TL;DR: This study carried out a genome-wide association study (GWAS) using 1,840 cases from the UK PBC Consortium and 5,163 UK population controls as part of theWTCCC3 to identify additional loci, and identified 12 new susceptibility loci and three further new loci in a meta-analysis of data from this study and previously published GWAS results.
Journal ArticleDOI
Susceptibility to Amoxicillin-Clavulanate-Induced Liver Injury is Influenced by Multiple HLA Class I and II Alleles
M. Isabel Lucena,Mariam Molokhia,Yufeng Shen,Thomas J. Urban,Guruprasad P. Aithal,Raúl J. Andrade,Christopher Day,Francisco Ruiz-Cabello,Peter T. Donaldson,Camilla Stephens,Munir Pirmohamed,Manuel Romero-Gómez,J.M. Navarro,Robert J. Fontana,Michael H Miller,Max Groome,Emmanuelle Bondon-Guitton,Anita Conforti,Bruno H. Ch. Stricker,Alfonso Carvajal,Luisa Ibáñez,Qun-Ying Yue,Michel Eichelbaum,Aris Floratos,Itsik Pe'er,Mark J. Daly,David Goldstein,John F. Dillon,Matthew R. Nelson,Paul B. Watkins,Ann K. Daly +30 more
TL;DR: Class I and II HLA genotypes affect susceptibility to AC-DILI, indicating the importance of the adaptive immune response in pathogenesis.
Journal ArticleDOI
Dense fine-mapping study identifies new susceptibility loci for primary biliary cirrhosis
Jimmy Z. Liu,Mohamed A. Almarri,Daniel J. Gaffney,George F. Mells,Luke Jostins,Heather J. Cordell,Samantha J. Ducker,Darren B. Day,Michael A. Heneghan,James Neuberger,Peter T. Donaldson,Andrew Bathgate,Andrew K. Burroughs,Mervyn H. Davies,David Jones,Graeme J.M. Alexander,Jeffrey C. Barrett,Richard Sandford,Carl A. Anderson +18 more
TL;DR: This study shows how data from dense fine-mapping arrays coupled with functional genomic data can be used to identify candidate causal variants for functional follow-up to implicate JAK-STAT and cytokine signaling in disease pathogenesis.