S
Saorin Kim
Researcher at Pasteur Institute
Publications - 76
Citations - 5432
Saorin Kim is an academic researcher from Pasteur Institute. The author has contributed to research in topics: Malaria & Plasmodium vivax. The author has an hindex of 27, co-authored 74 publications receiving 4452 citations. Previous affiliations of Saorin Kim include Médecins Sans Frontières.
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Journal ArticleDOI
A molecular marker of artemisinin-resistant Plasmodium falciparum malaria
Frédéric Ariey,Benoit Witkowski,Chanaki Amaratunga,Johann Beghain,Anne-Claire Langlois,Nimol Khim,Saorin Kim,Valentine Duru,Christiane Bouchier,Laurence Ma,Pharath Lim,Rithea Leang,Socheat Duong,Sokunthea Sreng,Seila Suon,Char Meng Chuor,Denis Mey Bout,Sandie Menard,William O. Rogers,Blaise Genton,Thierry Fandeur,Olivo Miotto,Pascal Ringwald,Jacques Le Bras,Antoine Berry,Jean Christophe Barale,Rick M. Fairhurst,Françoise Benoit-Vical,Odile Mercereau-Puijalon,Didier Menard +29 more
TL;DR: Strong correlations between the presence of a mutant allele, in vitro parasite survival rates and in vivo parasite clearance rates indicate that K13-propeller mutations are important determinants of artemisinin resistance.
Journal ArticleDOI
Novel phenotypic assays for the detection of artemisinin- resistant Plasmodium falciparum malaria in Cambodia: in-vitro and ex-vivo drug-response studies
Benoit Witkowski,Chanaki Amaratunga,Nimol Khim,Sokunthea Sreng,Pheaktra Chim,Saorin Kim,Pharath Lim,Pharath Lim,Sivanna Mao,Chantha Sopha,Baramey Sam,Jennifer M. Anderson,Socheat Duong,Char Meng Chuor,Walter R. J. Taylor,Seila Suon,Odile Mercereau-Puijalon,Rick M. Fairhurst,Didier Menard +18 more
TL;DR: The in-vitro RSA of 0-3 h ring-stage parasites provides a platform for the molecular characterisation of artemisinin resistance and the ex-vivo RSA can be easily implemented where surveillance for artemis inin resistance is needed.
Journal ArticleDOI
A Worldwide Map of Plasmodium Falciparum K13-Propeller Polymorphisms
Didier Menard,Nimol Khim,Johann Beghain,Ayola A. Adegnika,Ayola A. Adegnika,Mohammad Shafiul-Alam,Olukemi K. Amodu,Ghulam Rahim-Awab,Ghulam Rahim-Awab,Céline Barnadas,Céline Barnadas,Céline Barnadas,Antoine Berry,Yap Boum,Yap Boum,Maria Dorina Bustos,Jun Cao,Jun Hu Chen,Louis Collet,Liwang Cui,Garib Das Thakur,Alioune Dieye,Alioune Dieye,Djibrine Djalle,Monique A. Dorkenoo,Carole E. Eboumbou-Moukoko,Fe Espino,Thierry Fandeur,Maria de Fátima Ferreira-da-Cruz,Abebe A. Fola,Abebe A. Fola,Hans-Peter Fuehrer,Abdillahi Mohamed Hassan,Sócrates Herrera,Bouasy Hongvanthong,Sandrine Houzé,Maman Laminou Ibrahim,Mohammad Jahirul-Karim,Lubin Jiang,Shigeyuki Kano,Wasif Ali-Khan,Maniphone Khanthavong,Peter G. Kremsner,Marcus V. G. Lacerda,Rithea Leang,Mindy Leelawong,Mei Li,Khin Lin,Jean Baptiste Mazarati,Sandie Menard,Isabelle Morlais,Hypolite Muhindo-Mavoko,Hypolite Muhindo-Mavoko,Lise Musset,Kesara Na-Bangchang,Michael Nambozi,Karamoko Niaré,Harald Noedl,Jean-Bosco Ouédraogo,Dylan R. Pillai,Bruno Pradines,Bui Quang-Phuc,Michael Ramharter,Michael Ramharter,Milijaona Randrianarivelojosia,Jetsumon Sattabongkot,Abdiqani Sheikh-Omar,Kigbafori D. Silué,Sodiomon B. Sirima,Colin J. Sutherland,Din Syafruddin,Rachida Tahar,Lin Hua Tang,Offianan Andre Toure,Patrick Tshibangu-Wa-Tshibangu,Inès Vigan-Womas,Marian Warsame,Lyndes Wini,Sedigheh Zakeri,Saorin Kim,Rotha Eam,Laura Berne,Chanra Khean,Sophy Chy,Malen Ken,Kaknika Loch,Lydie Canier,Valentine Duru,Eric Legrand,Jean Christophe Barale,Barbara H. Stokes,Judith Straimer,Benoit Witkowski,David A. Fidock,Christophe Rogier,Pascal Ringwald,Frédéric Ariey,Odile Mercereau-Puijalon +97 more
TL;DR: In this article, the authors analyzed the K13-propeller sequence polymorphism in 14,037 samples collected in 59 countries in which malaria is endemic and identified 108 nonsynonymous K13 mutations, which showed marked geographic disparity in their frequency and distribution.
Journal ArticleDOI
A surrogate marker of piperaquine-resistant Plasmodium falciparum malaria: a phenotype–genotype association study
Benoit Witkowski,Valentine Duru,Nimol Khim,Leila S. Ross,Benjamin Saintpierre,Johann Beghain,Sophy Chy,Saorin Kim,Sopheakvatey Ke,Nimol Kloeung,Rotha Eam,Chanra Khean,Malen Ken,Kaknika Loch,Anthony Bouillon,Anais Domergue,Laurence Ma,Christiane Bouchier,Rithea Leang,Rekol Huy,Gregory Nuel,Jean-Christophe Barale,Eric Legrand,Pascal Ringwald,David A. Fidock,Odile Mercereau-Puijalon,Frédéric Ariey,Frédéric Ariey,Didier Menard +28 more
TL;DR: In this article, the authors obtained blood samples from Cambodian patients infected with P falciparum and treated with dihydroartemisinin-piperaquine, and patients were followed up for 42 days during the years 2009-15.
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Evidence of Plasmodium falciparum Malaria Multidrug Resistance to Artemisinin and Piperaquine in Western Cambodia: Dihydroartemisinin-Piperaquine Open-Label Multicenter Clinical Assessment.
Rithea Leang,Walter R. J. Taylor,Denis Mey Bouth,Lijiang Song,Lijiang Song,Joel Tarning,Joel Tarning,Meng Chuor Char,Saorin Kim,Benoit Witkowski,Valentine Duru,Anais Domergue,Nimol Khim,Pascal Ringwald,Didier Menard +14 more
TL;DR: Evidence of P. falciparum resistance to PP is shown in western Cambodia, an area of widespread artemisinin resistance, and new therapeutic strategies are urgently needed and must be tested.