Sophy Chy

TL;DR: In this article, the authors analyzed the K13-propeller sequence polymorphism in 14,037 samples collected in 59 countries in which malaria is endemic and identified 108 nonsynonymous K13 mutations, which showed marked geographic disparity in their frequency and distribution.

TL;DR: In this article, the authors obtained blood samples from Cambodian patients infected with P falciparum and treated with dihydroartemisinin-piperaquine, and patients were followed up for 42 days during the years 2009-15.

TL;DR: Combined ex vivo PSA and K13 genotyping provides a convenient monitor for both artemisinin and piperaquine resistance where dihydroartemisin in-piperquine is used and evaluate efficacy of alternative drugs.

TL;DR: The operational success of this diagnostic set-up proved that molecular testing and subsequent treatment is logistically achievable in field settings and will allow the detection of clusters of asymptomatic carriers and to provide useful epidemiological information.

TL;DR: Dot18S and CYTB, the new methods reported herein are highly sensitive, allow parasite DNA extraction as well as genus- and species-specific diagnosis of several hundreds of samples, and are amenable to high-throughput scaling up for larger sample sizes.