Philip J. Freda

TL;DR: Comparing the Effective Number of Codons with the Codon Adaptation Index shows that, in contrast to the other species, codon bias in D. grimshawi F element genes can be attributed primarily to selection instead of mutational biases, suggesting that density and types of transposons affect the degree of local heterochromatin formation.

TL;DR: Low temperature and short photoperiod resulted in reduced ovary size and level of development in D. suzukii, indicating that ovary development in females from the central plains population is more sensitive to lower temperature compared with populations examined from the northern United States and southern Canada.

TL;DR: To investigate whether developmental genetic correlations constrain the evolution thermal hardiness of the fly Drosophila melanogaster, quantitative genetic analyses revealed no significant genetic correlation for cold hardiness between life stages, suggesting complete genetic decoupling of Thermal hardiness across the metamorphic boundary.

TL;DR: Cross-development phenotypic correlations for acclimation responses suggest that plasticity itself may be developmentally constrained, though rigorously testing this hypothesis requires more experimentation.

TL;DR: In this article, the authors describe the prevalence and clinical significance of addictive and affective comorbidities as risk factors for OUD development as a basis for rational opioid prescribing and OUD treatment and to improve efforts to prevent the disorder.