P
Pilar Garcia-Broncano
Researcher at Ragon Institute of MGH, MIT and Harvard
Publications - 33
Citations - 1030
Pilar Garcia-Broncano is an academic researcher from Ragon Institute of MGH, MIT and Harvard. The author has contributed to research in topics: Immune system & Viremia. The author has an hindex of 11, co-authored 30 publications receiving 612 citations. Previous affiliations of Pilar Garcia-Broncano include Carlos III Health Institute & Hospital General Universitario Gregorio Marañón.
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Journal ArticleDOI
Loss of Bcl-6-Expressing T Follicular Helper Cells and Germinal Centers in COVID-19.
Naoki Kaneko,Hsiao-Hsuan Kuo,Julie Boucau,Jocelyn R. Farmer,Hugues Allard-Chamard,Vinay Mahajan,Alicja Piechocka-Trocha,Kristina Lefteri,Matthew Osborn,Julia Bals,Yannic C. Bartsch,Nathalie Bonheur,Timothy M. Caradonna,Josh Chevalier,Fatema Z. Chowdhury,Thomas J. Diefenbach,Kevin Einkauf,Jon Fallon,Jared Feldman,Kelsey K. Finn,Pilar Garcia-Broncano,Ciputra Adijaya Hartana,Blake M. Hauser,Chenyang Jiang,Paulina Kaplonek,Marshall Karpell,Eric C. Koscher,Xiao-Dong Lian,Hang Liu,Jinqing Liu,Ngoc L. Ly,Ashlin R. Michell,Yelizaveta Rassadkina,Kyra Seiger,Libera Sessa,Sally Shin,Nishant K. Singh,Weiwei Sun,Xiaoming Sun,Hannah J. Ticheli,Michael T. Waring,Alex Lee Zhu,Galit Alter,Jonathan Z. Li,Daniel Lingwood,Aaron G. Schmidt,Mathias Lichterfeld,Bruce D. Walker,Xu G. Yu,Robert F. Padera,Shiv Pillai +50 more
TL;DR: Data identify defective Bcl-6+ TFH cell generation and dysregulated humoral immune induction early in COVID-19 disease, providing a mechanistic explanation for the limited durability of antibody responses in coronavirus infections and suggest that achieving herd immunity through natural infection may be difficult.
Journal ArticleDOI
Early antiretroviral therapy in neonates with HIV-1 infection restricts viral reservoir size and induces a distinct innate immune profile
Pilar Garcia-Broncano,Shivaali Maddali,Kevin Einkauf,Kevin Einkauf,Chenyang Jiang,Chenyang Jiang,Ce Gao,Joshua M. Chevalier,Joshua M. Chevalier,Fatema Z. Chowdhury,Kenneth Maswabi,Gbolahan Ajibola,Sikhulile Moyo,Terence Mohammed,Thabani Ncube,Joseph Makhema,Patrick Jean-Philippe,Xu G. Yu,Xu G. Yu,Xu G. Yu,Kathleen M. Powis,Shahin Lockman,Shahin Lockman,Daniel R. Kuritzkes,Daniel R. Kuritzkes,Roger L. Shapiro,Mathias Lichterfeld,Mathias Lichterfeld,Mathias Lichterfeld +28 more
TL;DR: Examination of a unique cohort of neonates with HIV-1 infection from Botswana who started ART shortly after birth and were followed longitudinally for about 2 years shows multiple clear benefits of rapid antiretroviral initiation, including an extremely small reservoir of intact proviral sequences, a reduction in abnormal T cell immune activation, and an innate immune profile that displays distinct features of improved antiviral activity and is associated with intact Proviral reservoir size.
Journal ArticleDOI
Dendronized Anionic Gold Nanoparticles: Synthesis, Characterization, and Antiviral Activity.
Cornelia E. Peña-González,Pilar Garcia-Broncano,M. Francesca Ottaviani,Michela Cangiotti,Alberto Fattori,Margarita Hierro-Oliva,Margarita Hierro-Oliva,M. Luisa González-Martín,M. Luisa González-Martín,Jorge Pérez-Serrano,Rafael Gómez,Rafael Gómez,M. Ángeles Muñoz-Fernández,Javier Sánchez-Nieves,Javier Sánchez-Nieves,F. Javier de la Mata,F. Javier de la Mata +16 more
TL;DR: Toxicity assays of AuNPs showed that those produced through direct reaction were less toxic than those obtained by ligand exchange, and inhibition of HIV-1 infection was higher in the case of dendronized AuNPS than in dendrons.
Journal ArticleDOI
Prevention of vaginal and rectal herpes simplex virus type 2 transmission in mice: mechanism of antiviral action.
Rafael Ceña-Diez,Enrique Vacas-Córdoba,Pilar Garcia-Broncano,de la Mata Fj,Rafael Gómez,Marek Maly,M. A. Muñoz-Fernández +6 more
TL;DR: This research represents the first demonstration that transmission of HSV-2 can be blocked by vaginal/rectal application of G1-S4 or G2-S16, providing a step forward to prevent HSV -2 transmission in humans.
Journal ArticleDOI
The Loss of Bcl-6 Expressing T Follicular Helper Cells and the Absence of Germinal Centers in COVID-19
Naoki Kaneko,Hsiao-Hsuan Kuo,Julie Boucau,Jocelyn R. Farmer,Hugues Allard-Chamard,Hugues Allard-Chamard,Vinay Mahajan,Vinay Mahajan,Alicja Piechocka-Trocha,Alicja Piechocka-Trocha,Kristina Lefteri,Matt Osborn,Julia Bals,Yannic C. Bartsch,Nathalie Bonheur,Timothy M. Caradonna,Josh Chevalier,Fatema Z. Chowdhury,Thomas J. Diefenbach,Kevin Einkauf,Jon Fallon,Jared Feldman,Kelsey K. Finn,Pilar Garcia-Broncano,Ciputra Adijaya Hartana,Blake M. Hauser,Chenyang Jiang,Paulina Kaplonek,Marshall Karpell,Eric C. Koscher,Xiao-Dong Lian,Hang Liu,Jinqing Liu,Ngoc L. Ly,Ashlin R. Michell,Yelizaveta Rassadkina,Kyra Seiger,Libera Sessa,Sally Shin,Nishant K. Singh,Weiwei Sun,Xiaoming Sun,Hannah J. Ticheli,Michael T. Waring,Michael T. Waring,Alex Lee Zhu,Jonathan Z. Li,Daniel Lingwood,Aaron G. Schmidt,Aaron G. Schmidt,Matthias Lichterfeld,Matthias Lichterfeld,Bruce D. Walker,Bruce D. Walker,Bruce D. Walker,Xu G. Yu,Robert F. Padera,Shiv Pillai +57 more
TL;DR: Analysis of postmortem thoracic lymph nodes and spleens in acute SARS-CoV-2 infection identifies defective Bcl-6+TFH cell generation and dysregulated humoral immune induction early in COVID-19 disease, providing a mechanistic explanation for the limited durability of antibody responses in coronavirus infections and suggest that achieving herd immunity through natural infection may be difficult.