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Naoki Kaneko
Researcher at Ragon Institute of MGH, MIT and Harvard
Publications - 24
Citations - 1149
Naoki Kaneko is an academic researcher from Ragon Institute of MGH, MIT and Harvard. The author has contributed to research in topics: Cytotoxic T cell & CD8. The author has an hindex of 11, co-authored 24 publications receiving 641 citations. Previous affiliations of Naoki Kaneko include Kyushu University & Massachusetts Institute of Technology.
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Journal ArticleDOI
Loss of Bcl-6-Expressing T Follicular Helper Cells and Germinal Centers in COVID-19.
Naoki Kaneko,Hsiao-Hsuan Kuo,Julie Boucau,Jocelyn R. Farmer,Hugues Allard-Chamard,Vinay Mahajan,Alicja Piechocka-Trocha,Kristina Lefteri,Matthew Osborn,Julia Bals,Yannic C. Bartsch,Nathalie Bonheur,Timothy M. Caradonna,Josh Chevalier,Fatema Z. Chowdhury,Thomas J. Diefenbach,Kevin Einkauf,Jon Fallon,Jared Feldman,Kelsey K. Finn,Pilar Garcia-Broncano,Ciputra Adijaya Hartana,Blake M. Hauser,Chenyang Jiang,Paulina Kaplonek,Marshall Karpell,Eric C. Koscher,Xiao-Dong Lian,Hang Liu,Jinqing Liu,Ngoc L. Ly,Ashlin R. Michell,Yelizaveta Rassadkina,Kyra Seiger,Libera Sessa,Sally Shin,Nishant K. Singh,Weiwei Sun,Xiaoming Sun,Hannah J. Ticheli,Michael T. Waring,Alex Lee Zhu,Galit Alter,Jonathan Z. Li,Daniel Lingwood,Aaron G. Schmidt,Mathias Lichterfeld,Bruce D. Walker,Xu G. Yu,Robert F. Padera,Shiv Pillai +50 more
TL;DR: Data identify defective Bcl-6+ TFH cell generation and dysregulated humoral immune induction early in COVID-19 disease, providing a mechanistic explanation for the limited durability of antibody responses in coronavirus infections and suggest that achieving herd immunity through natural infection may be difficult.
Journal ArticleDOI
Cytotoxic CD4+ T lymphocytes may induce endothelial cell apoptosis in systemic sclerosis
Takashi Maehara,Takashi Maehara,Naoki Kaneko,Naoki Kaneko,Cory A. Perugino,Cory A. Perugino,Hamid Mattoo,Jesper Kers,Hugues Allard-Chamard,Hugues Allard-Chamard,Vinay Mahajan,Vinay Mahajan,Hang Liu,Samuel J.H. Murphy,Musie Ghebremichael,David A. Fox,Aimee S. Payne,Robert Lafyatis,John H. Stone,Dinesh Khanna,Shiv Pillai +20 more
TL;DR: Quantitative analyses of T cell infiltrates in the skin of thirty-five untreated patients with early diffuse SSc show that CD4+ cytotoxic T cells and CD8+ T cells contribute prominently to these infiltrates, and suggest that cytot toxic T cells may induce the apoptotic death of endothelial and other cells in systemic sclerosis.
Journal ArticleDOI
CD206+ tumor-associated macrophages promote proliferation and invasion in oral squamous cell carcinoma via EGF production
A. S.M.Rafiul Haque,Masafumi Moriyama,Keigo Kubota,Noriko Ishiguro,Mizuki Sakamoto,Akira Chinju,Keita Mochizuki,Taiki Sakamoto,Naoki Kaneko,Ryusuke Munemura,Takashi Maehara,Akihiko Tanaka,Jun Nosuke Hayashida,Shintaro Kawano,Tamotsu Kiyoshima,Seiji Nakamura +15 more
TL;DR: Investigation of the expression and function of TAM subsets in oral squamous cell carcinoma found that CD206+ TAMs might play a critical role in the proliferation of OSCC via EGF production, which is positively correlated with worse clinical prognosis.
Journal ArticleDOI
Increased expression of interleukin-6 predicts poor response to chemoradiotherapy and unfavorable prognosis in oral squamous cell carcinoma.
Teppei Jinno,Shintaro Kawano,Yasuyuki Maruse,Ryota Matsubara,Yuichi Goto,Taiki Sakamoto,Yuma Hashiguchi,Naoki Kaneko,Hideaki Tanaka,Ryoji Kitamura,Takeshi Toyoshima,Akiko Jinno,Masafumi Moriyama,Kazunari Oobu,Tamotsu Kiyoshima,Seiji Nakamura +15 more
TL;DR: IL-6 signaling possibly is involved in the progression and treatment-resistance of OSCC and IL-6 expression in cancer cells could be a useful predictive factor of poor response to chemoradiotherapy and unfavorable prognosis.
Journal ArticleDOI
B lymphocytes directly contribute to tissue fibrosis in patients with IgG4-related disease.
Emanuel Della-Torre,Emanuel Della-Torre,Elena Rigamonti,Cory A. Perugino,Cory A. Perugino,Simona Baghai-Sain,Na Sun,Naoki Kaneko,Naoki Kaneko,Takashi Maehara,Takashi Maehara,Lucrezia Rovati,Lucrezia Rovati,Maurilio Ponzoni,Raffaella Milani,Marco Lanzillotta,Vinay Mahajan,Hamid Mattoo,Ivan Molineris,Vikram Deshpande,John H. Stone,Massimo Falconi,Angelo A. Manfredi,Shiv Pillai +23 more
TL;DR: It is demonstrated that B cells, contribute directly to tissue fibrosis in IgG4-RD and these unanticipated pro-fibrotic properties of B lymphocytes, particularly of plasmablasts, might be relevant for fibrogenesis in other fibro-inflammatory disorders and for wound healing processes in physiological conditions.