K
Kelsey K. Finn
Researcher at Ragon Institute of MGH, MIT and Harvard
Publications - 3
Citations - 602
Kelsey K. Finn is an academic researcher from Ragon Institute of MGH, MIT and Harvard. The author has contributed to research in topics: Immune system & B cell. The author has an hindex of 2, co-authored 2 publications receiving 314 citations.
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Journal ArticleDOI
Loss of Bcl-6-Expressing T Follicular Helper Cells and Germinal Centers in COVID-19.
Naoki Kaneko,Hsiao-Hsuan Kuo,Julie Boucau,Jocelyn R. Farmer,Hugues Allard-Chamard,Vinay Mahajan,Alicja Piechocka-Trocha,Kristina Lefteri,Matthew Osborn,Julia Bals,Yannic C. Bartsch,Nathalie Bonheur,Timothy M. Caradonna,Josh Chevalier,Fatema Z. Chowdhury,Thomas J. Diefenbach,Kevin Einkauf,Jon Fallon,Jared Feldman,Kelsey K. Finn,Pilar Garcia-Broncano,Ciputra Adijaya Hartana,Blake M. Hauser,Chenyang Jiang,Paulina Kaplonek,Marshall Karpell,Eric C. Koscher,Xiao-Dong Lian,Hang Liu,Jinqing Liu,Ngoc L. Ly,Ashlin R. Michell,Yelizaveta Rassadkina,Kyra Seiger,Libera Sessa,Sally Shin,Nishant K. Singh,Weiwei Sun,Xiaoming Sun,Hannah J. Ticheli,Michael T. Waring,Alex Lee Zhu,Galit Alter,Jonathan Z. Li,Daniel Lingwood,Aaron G. Schmidt,Mathias Lichterfeld,Bruce D. Walker,Xu G. Yu,Robert F. Padera,Shiv Pillai +50 more
TL;DR: Data identify defective Bcl-6+ TFH cell generation and dysregulated humoral immune induction early in COVID-19 disease, providing a mechanistic explanation for the limited durability of antibody responses in coronavirus infections and suggest that achieving herd immunity through natural infection may be difficult.
Journal ArticleDOI
The Loss of Bcl-6 Expressing T Follicular Helper Cells and the Absence of Germinal Centers in COVID-19
Naoki Kaneko,Hsiao-Hsuan Kuo,Julie Boucau,Jocelyn R. Farmer,Hugues Allard-Chamard,Hugues Allard-Chamard,Vinay Mahajan,Vinay Mahajan,Alicja Piechocka-Trocha,Alicja Piechocka-Trocha,Kristina Lefteri,Matt Osborn,Julia Bals,Yannic C. Bartsch,Nathalie Bonheur,Timothy M. Caradonna,Josh Chevalier,Fatema Z. Chowdhury,Thomas J. Diefenbach,Kevin Einkauf,Jon Fallon,Jared Feldman,Kelsey K. Finn,Pilar Garcia-Broncano,Ciputra Adijaya Hartana,Blake M. Hauser,Chenyang Jiang,Paulina Kaplonek,Marshall Karpell,Eric C. Koscher,Xiao-Dong Lian,Hang Liu,Jinqing Liu,Ngoc L. Ly,Ashlin R. Michell,Yelizaveta Rassadkina,Kyra Seiger,Libera Sessa,Sally Shin,Nishant K. Singh,Weiwei Sun,Xiaoming Sun,Hannah J. Ticheli,Michael T. Waring,Michael T. Waring,Alex Lee Zhu,Jonathan Z. Li,Daniel Lingwood,Aaron G. Schmidt,Aaron G. Schmidt,Matthias Lichterfeld,Matthias Lichterfeld,Bruce D. Walker,Bruce D. Walker,Bruce D. Walker,Xu G. Yu,Robert F. Padera,Shiv Pillai +57 more
TL;DR: Analysis of postmortem thoracic lymph nodes and spleens in acute SARS-CoV-2 infection identifies defective Bcl-6+TFH cell generation and dysregulated humoral immune induction early in COVID-19 disease, providing a mechanistic explanation for the limited durability of antibody responses in coronavirus infections and suggest that achieving herd immunity through natural infection may be difficult.
Journal ArticleDOI
SARS-CoV-2 epitope-specific CD4+ memory T cell responses across COVID-19 disease severity and antibody durability
Ryan W. Nelson,Yuezhou Chen,Olivia L. Venezia,Richard Majerus,Daniel Shin,Mary Carrington,Duane R. Wesemann,James J. Moon,Andrew D. Luster,B. A. Abayneh,P. Allen,Galit Alter,Diane Antille,Katrina L Armstrong,Alejandro B. Balazs,Julia Bals,M. Barbash,Yannic C. Bartsch,Julie Boucau,Siobhan F Boyce,Janet F. Braley,Karen Marie Coperich Branch,Katherine Broderick,Julia Carney,Andrew T. Chan,Josh Chevalier,Fatema Z. Chowdhury,George Q. Daley,Susan P. Davidson,Michael Dougan,D. A. Drew,Kevin Einkauf,Ashley Elliman,Jonathan K. Fallon,Liz Fedirko,Kelsey K. Finn,Keith T. Flaherty,Jeanne Flannery,Pamela J. Forde,Pilar Garcia-Broncano,Elise Gettings,David E. Golan,Amanda J. Griffin,Sheila Grimmel,Kathleen A. Grinke,Kathryn T. Hall,Ciputra Adijaya Hartana,Michael D. Healy,H. Heller,Deborah Henault,Grace Holland,Chenyang Jiang,Nikolaus Jilg,Paulina Kaplonek,Marshall Karpell,Chantal Kayitesi,Evan C. Lam,V Roberto Lavalle,Kristina Lefteri,Xiao-Mei Lian,Mathias Lichterfeld,Daniel Lingwood,Huan Liu,Jinqing Liu,Yuting Lu,Sarah Luthern,N. Ly,J. Marchewka,Brittani Martino,R. McNamara,Ashlin R. Michell,Ilan Millstrom,Noah Miranda,Christian Nambu,Susan Nelson,Marjorie Noone,Claire O'Callaghan,Christine Ommerborn,Matthew Osborn,Lois Chris Pacheco,Nicole Phan,Shiv Pillai,F. A. Porto,Yelizaveta Rassadkina,Alexandra Reissis,Alexandra Rosenthal,Francis Ruzicka,Edward Francis Ryan,Kyra Seiger,K. Selleck,Libera Sessa,Arlene H. Sharpe,Christianne Sharr,Sally Shin,Nishant K. Singh,Sue Slaughenhaupt,Kim Sheppard,Weiwei Sun,Xiaoming Sun,Elizabeth Suschana,Hannah J. Ticheli,Alicja Trocha-Piechocka,Vivine Wilson,Colline Wong,Daniel P Worrall,Alex Lee Zhu,Zachary Manickas-Hill,Edward Demers,Kelly Judge,Musie Ghebremichael,Peggy S Lai,Jonathan Z. Li,Bruce D. Walker,Maureen P. Martin,Yuko Yuki +114 more
TL;DR: Analysis of SARS-CoV-2-specific CD4+ T cells responses in a subset of individuals with sustained anti-S antibody responses following viral clearance also revealed an increased proportion of memory cTfh cells, indicating efficient early disease control also predicts favorable long-term adaptive immunity.