H
Hugues Allard-Chamard
Researcher at Ragon Institute of MGH, MIT and Harvard
Publications - 33
Citations - 970
Hugues Allard-Chamard is an academic researcher from Ragon Institute of MGH, MIT and Harvard. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 8, co-authored 23 publications receiving 509 citations. Previous affiliations of Hugues Allard-Chamard include Massachusetts Institute of Technology & Centre Hospitalier Universitaire de Sherbrooke.
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Journal ArticleDOI
Loss of Bcl-6-Expressing T Follicular Helper Cells and Germinal Centers in COVID-19.
Naoki Kaneko,Hsiao-Hsuan Kuo,Julie Boucau,Jocelyn R. Farmer,Hugues Allard-Chamard,Vinay Mahajan,Alicja Piechocka-Trocha,Kristina Lefteri,Matthew Osborn,Julia Bals,Yannic C. Bartsch,Nathalie Bonheur,Timothy M. Caradonna,Josh Chevalier,Fatema Z. Chowdhury,Thomas J. Diefenbach,Kevin Einkauf,Jon Fallon,Jared Feldman,Kelsey K. Finn,Pilar Garcia-Broncano,Ciputra Adijaya Hartana,Blake M. Hauser,Chenyang Jiang,Paulina Kaplonek,Marshall Karpell,Eric C. Koscher,Xiao-Dong Lian,Hang Liu,Jinqing Liu,Ngoc L. Ly,Ashlin R. Michell,Yelizaveta Rassadkina,Kyra Seiger,Libera Sessa,Sally Shin,Nishant K. Singh,Weiwei Sun,Xiaoming Sun,Hannah J. Ticheli,Michael T. Waring,Alex Lee Zhu,Galit Alter,Jonathan Z. Li,Daniel Lingwood,Aaron G. Schmidt,Mathias Lichterfeld,Bruce D. Walker,Xu G. Yu,Robert F. Padera,Shiv Pillai +50 more
TL;DR: Data identify defective Bcl-6+ TFH cell generation and dysregulated humoral immune induction early in COVID-19 disease, providing a mechanistic explanation for the limited durability of antibody responses in coronavirus infections and suggest that achieving herd immunity through natural infection may be difficult.
Journal ArticleDOI
Identification of galectin-3 as an autoantigen in patients with IgG4-related disease.
Cory A. Perugino,Cory A. Perugino,Sultan B. AlSalem,Sultan B. AlSalem,Hamid Mattoo,Emanuel Della-Torre,Vinay Mahajan,Vinay Mahajan,Gayathri Ganesh,Hugues Allard-Chamard,Zachary S. Wallace,Sydney B. Montesi,Johannes Kreuzer,Wilhelm Haas,John H. Stone,Shiv Pillai,Shiv Pillai +16 more
TL;DR: Affinity chromatography using patient‐derived mAbs identifies relevant autoantigens in patients with IgG4‐RD and marked increases in levels of circulating IgG 4 and IgE observed clinically are, at least in part, caused by the development of IgG3‐ and Ig E‐specific autoantibody responses.
Journal ArticleDOI
Cytotoxic CD4+ T lymphocytes may induce endothelial cell apoptosis in systemic sclerosis
Takashi Maehara,Takashi Maehara,Naoki Kaneko,Naoki Kaneko,Cory A. Perugino,Cory A. Perugino,Hamid Mattoo,Jesper Kers,Hugues Allard-Chamard,Hugues Allard-Chamard,Vinay Mahajan,Vinay Mahajan,Hang Liu,Samuel J.H. Murphy,Musie Ghebremichael,David A. Fox,Aimee S. Payne,Robert Lafyatis,John H. Stone,Dinesh Khanna,Shiv Pillai +20 more
TL;DR: Quantitative analyses of T cell infiltrates in the skin of thirty-five untreated patients with early diffuse SSc show that CD4+ cytotoxic T cells and CD8+ T cells contribute prominently to these infiltrates, and suggest that cytot toxic T cells may induce the apoptotic death of endothelial and other cells in systemic sclerosis.
Journal ArticleDOI
CD4+ and CD8+ cytotoxic T lymphocytes may induce mesenchymal cell apoptosis in IgG4-related disease
Cory A. Perugino,Cory A. Perugino,Naoki Kaneko,Naoki Kaneko,Takashi Maehara,Takashi Maehara,Hamid Mattoo,Jesper Kers,Jesper Kers,Hugues Allard-Chamard,Hugues Allard-Chamard,Vinay Mahajan,Vinay Mahajan,Hang Liu,Hang Liu,Emanuel Della-Torre,Samuel J.H. Murphy,Musie Ghebremichael,Zachary S. Wallace,Marcy B. Bolster,Liam Harvey,Geetha H. Mylvaganam,Yesim Tuncay,Lloyd L. Liang,Sydney B. Montesi,Xiuwei Zhang,Akira Tinju,Keita Mochizuki,Ryusuke Munemura,Mizuki Sakamoto,Masafumi Moriyama,Seiji Nakamura,Nir Yosef,John H. Stone,Shiv Pillai +34 more
TL;DR: It is established that among circulating CD4+CTLs in IgG4-RD, CD27loCD28loCD57hi cells are the dominant effector subset, exhibit marked clonal-expansion and differentially express genes relevant to cytotoxicity, activation and enhanced metabolism.
Journal ArticleDOI
The Loss of Bcl-6 Expressing T Follicular Helper Cells and the Absence of Germinal Centers in COVID-19
Naoki Kaneko,Hsiao-Hsuan Kuo,Julie Boucau,Jocelyn R. Farmer,Hugues Allard-Chamard,Hugues Allard-Chamard,Vinay Mahajan,Vinay Mahajan,Alicja Piechocka-Trocha,Alicja Piechocka-Trocha,Kristina Lefteri,Matt Osborn,Julia Bals,Yannic C. Bartsch,Nathalie Bonheur,Timothy M. Caradonna,Josh Chevalier,Fatema Z. Chowdhury,Thomas J. Diefenbach,Kevin Einkauf,Jon Fallon,Jared Feldman,Kelsey K. Finn,Pilar Garcia-Broncano,Ciputra Adijaya Hartana,Blake M. Hauser,Chenyang Jiang,Paulina Kaplonek,Marshall Karpell,Eric C. Koscher,Xiao-Dong Lian,Hang Liu,Jinqing Liu,Ngoc L. Ly,Ashlin R. Michell,Yelizaveta Rassadkina,Kyra Seiger,Libera Sessa,Sally Shin,Nishant K. Singh,Weiwei Sun,Xiaoming Sun,Hannah J. Ticheli,Michael T. Waring,Michael T. Waring,Alex Lee Zhu,Jonathan Z. Li,Daniel Lingwood,Aaron G. Schmidt,Aaron G. Schmidt,Matthias Lichterfeld,Matthias Lichterfeld,Bruce D. Walker,Bruce D. Walker,Bruce D. Walker,Xu G. Yu,Robert F. Padera,Shiv Pillai +57 more
TL;DR: Analysis of postmortem thoracic lymph nodes and spleens in acute SARS-CoV-2 infection identifies defective Bcl-6+TFH cell generation and dysregulated humoral immune induction early in COVID-19 disease, providing a mechanistic explanation for the limited durability of antibody responses in coronavirus infections and suggest that achieving herd immunity through natural infection may be difficult.