Hsiao-Hsuan Kuo

TL;DR: Data identify defective Bcl-6+ TFH cell generation and dysregulated humoral immune induction early in COVID-19 disease, providing a mechanistic explanation for the limited durability of antibody responses in coronavirus infections and suggest that achieving herd immunity through natural infection may be difficult.

TL;DR: massive single-genome, near-full-length next-generation sequencing of HIV-1 DNA derived from unfractionated peripheral blood mononuclear cells, ex vivo-isolated CD4+ T cells, and subsets of functionally polarized memory CD4- T cells suggests that clonal proliferation of Th1-polarized CD4+.

TL;DR: It is demonstrated that the anti‐apoptotic protein BIRC5 and its upstream regulator OX40 can promote survival of HIV‐1‐infected reservoir CD4+ T cells, specifically during clonal proliferation.

TL;DR: Analysis of postmortem thoracic lymph nodes and spleens in acute SARS-CoV-2 infection identifies defective Bcl-6+TFH cell generation and dysregulated humoral immune induction early in COVID-19 disease, providing a mechanistic explanation for the limited durability of antibody responses in coronavirus infections and suggest that achieving herd immunity through natural infection may be difficult.

TL;DR: Continuous progress in understanding phenotypic and functional properties of viral reservoir cells provides clues for novel clinical interventions to destabilize viral persistence during antiretroviral therapy.