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Pontus Boström
Researcher at Karolinska Institutet
Publications - 41
Citations - 10722
Pontus Boström is an academic researcher from Karolinska Institutet. The author has contributed to research in topics: Lipid droplet & Lipid metabolism. The author has an hindex of 26, co-authored 40 publications receiving 9173 citations. Previous affiliations of Pontus Boström include Sahlgrenska University Hospital & University of Gothenburg.
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Journal ArticleDOI
A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis
Pontus Boström,Jun Wu,Mark P. Jedrychowski,Anisha Korde,Li Ye,James C. Lo,Kyle A. Rasbach,Elisabeth A. Boström,Jang Hyun Choi,Jonathan Z. Long,Shingo Kajimura,Maria Cristina Zingaretti,Birgitte F. Vind,Hua Tu,Saverio Cinti,Kurt Højlund,Steven P. Gygi,Bruce M. Spiegelman +17 more
TL;DR: This article showed that PGC1α expression in muscle stimulates an increase in expression of FNDC5, a membrane protein that is cleaved and secreted as a newly identified hormone, irisin.
Journal ArticleDOI
Beige Adipocytes Are a Distinct Type of Thermogenic Fat Cell in Mouse and Human
Jun Wu,Pontus Boström,Lauren M. Sparks,Li Ye,Jang Hyun Choi,An Hoa Giang,Melin J. Khandekar,Kirsi A. Virtanen,Pirjo Nuutila,Gert Schaart,Kexin Huang,Hua Tu,Wouter D. van Marken Lichtenbelt,Joris Hoeks,Sven Enerbäck,Patrick Schrauwen,Bruce M. Spiegelman +16 more
TL;DR: Beige cells have a gene expression pattern distinct from either white or brown fat and are preferentially sensitive to the polypeptide hormone irisin, providing evidence that previously identified brown fat deposits in adult humans are composed of beige adipocytes.
Journal ArticleDOI
Anti-diabetic drugs inhibit obesity-linked phosphorylation of PPARγ by Cdk5
Jang Hyun Choi,Alexander S. Banks,Jennifer L. Estall,Shingo Kajimura,Pontus Boström,Dina Laznik,Jorge L. Ruas,Michael J. Chalmers,Theodore M. Kamenecka,Matthias Blüher,Patrick R. Griffin,Bruce M. Spiegelman +11 more
TL;DR: Findings strongly suggest that Cdk5-mediated phosphorylation of PPARγ may be involved in the pathogenesis of insulin-resistance, and present an opportunity for development of an improved generation of anti-diabetic drugs throughPPARγ.
Journal ArticleDOI
β-Aminoisobutyric Acid Induces Browning of White Fat and Hepatic β-Oxidation and Is Inversely Correlated with Cardiometabolic Risk Factors
Lee D. Roberts,Pontus Boström,Pontus Boström,John F. O'Sullivan,Robert T. Schinzel,Gregory D. Lewis,Gregory D. Lewis,Andre Dejam,Youn-Kyoung Lee,Melinda J. Palma,Sondra Calhoun,Anastasia Georgiadi,Ming-Huei Chen,Ming-Huei Chen,Vasan S. Ramachandran,Vasan S. Ramachandran,Martin G. Larson,Martin G. Larson,Claude Bouchard,Tuomo Rankinen,Amanda Souza,Clary B. Clish,Thomas J. Wang,Thomas J. Wang,Jennifer L. Estall,Alexander A. Soukas,Chad A. Cowan,Bruce M. Spiegelman,Robert E. Gerszten,Robert E. Gerszten +29 more
TL;DR: In humans, plasma BAIBA concentrations are increased with exercise and inversely associated with metabolic risk factors, and β-aminoisobutyric acid (BAIBA) may contribute to exercise-induced protection from metabolic diseases.
Journal ArticleDOI
C/EBPβ controls exercise-induced cardiac growth and protects against pathological cardiac remodeling
Pontus Boström,Nina Mann,Jun Wu,Pablo A. Quintero,Eva Plovie,Daniela Panáková,Rana K. Gupta,Chunyang Xiao,Calum A. MacRae,Anthony Rosenzweig,Bruce M. Spiegelman +10 more
TL;DR: Data indicate that C/EBPβ represses cardiomyocyte growth and proliferation in the adult mammalian heart and that reduction in C/ EBPβ is a central signal in physiologic hypertrophy and proliferation.