P
Preeti Subramanian
Researcher at National Institutes of Health
Publications - 33
Citations - 1501
Preeti Subramanian is an academic researcher from National Institutes of Health. The author has contributed to research in topics: PEDF & Phospholipase A2. The author has an hindex of 17, co-authored 27 publications receiving 1277 citations. Previous affiliations of Preeti Subramanian include VCU Medical Center & Virginia Commonwealth University.
Papers
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Journal ArticleDOI
Ceramide 1-Phosphate Is a Direct Activator of Cytosolic Phospholipase A2
Benjamin J. Pettus,Alicja Bielawska,Preeti Subramanian,Dayanjan S. Wijesinghe,Michael Maceyka,Christina C. Leslie,John H. Evans,Jessica Freiberg,Patrick Roddy,Yusuf A. Hannun,Charles E. Chalfant,Charles E. Chalfant +11 more
TL;DR: This study identifies Cer-1-P as an anionic lipid that translocates and directly activates cPLA2, demonstrating a role for this bioactive lipid in the mediation of inflammatory responses.
Journal ArticleDOI
The immunosuppressant drug FTY720 inhibits cytosolic phospholipase A2 independently of sphingosine-1-phosphate receptors.
Shawn G. Payne,Carole A. Oskeritzian,Rachael Griffiths,Preeti Subramanian,Suzanne E. Barbour,Charles E. Chalfant,Sheldon Milstien,Sarah Spiegel +7 more
TL;DR: This study has uncovered a unique action of FTY720 as an inhibitor of cPLA2α and hence on production of all eicosanoids and its results have important implications for the potential therapeutic mechanism of action ofFTY720 in eICosanoid-driven inflammatory disorders such as asthma and multiple sclerosis.
Journal ArticleDOI
Ceramide 1-Phosphate Acts as a Positive Allosteric Activator of Group IVA Cytosolic Phospholipase A2α and Enhances the Interaction of the Enzyme with Phosphatidylcholine
Preeti Subramanian,Robert V. Stahelin,Zdzislaw M. Szulc,Alicja Bielawska,Wonhwa Cho,Charles E. Chalfant,Charles E. Chalfant +6 more
TL;DR: It is suggested that C-1-P may function to recruit cPLA2α to intracellular membranes as well as allosterically activate the membrane-associated enzyme.
Journal ArticleDOI
Ceramide-1-phosphate binds group IVA cytosolic phospholipase a2 via a novel site in the C2 domain.
Robert V. Stahelin,Preeti Subramanian,Mohsin Vora,Wonhwa Cho,Charles E. Chalfant,Charles E. Chalfant +5 more
TL;DR: A novel C1P interaction site mapped to the cationic β-groove of the C2 domain of cPLA2α is demonstrated for the first time.
Journal ArticleDOI
Ceramide-1-phosphate is required for the translocation of group IVA cytosolic phospholipase A2 and prostaglandin synthesis
Nadia F. Lamour,Preeti Subramanian,Dayanjan S. Wijesinghe,Robert V. Stahelin,Robert V. Stahelin,Joseph V. Bonventre,Charles E. Chalfant,Charles E. Chalfant +7 more
TL;DR: It is demonstrated that C1P is a proximal and required bioactive lipid for the translocation of cPLA2α to intracellular membranes in response to inflammatory agonists (e.g. calcium ionophore and ATP).