P
Puneeth Iyengar
Researcher at University of Texas Southwestern Medical Center
Publications - 144
Citations - 8864
Puneeth Iyengar is an academic researcher from University of Texas Southwestern Medical Center. The author has contributed to research in topics: Radiation therapy & Medicine. The author has an hindex of 35, co-authored 118 publications receiving 6683 citations. Previous affiliations of Puneeth Iyengar include Albert Einstein College of Medicine & University of Texas at Austin.
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Journal ArticleDOI
Standard-dose versus high-dose conformal radiotherapy with concurrent and consolidation carboplatin plus paclitaxel with or without cetuximab for patients with stage IIIA or IIIB non-small-cell lung cancer (RTOG 0617): a randomised, two-by-two factorial phase 3 study
Jeffrey D. Bradley,Rebecca Paulus,Ritsuko Komaki,Gregory A. Masters,George R. Blumenschein,Steven E. Schild,Jeffrey A. Bogart,Chen Hu,Kenneth M. Forster,Anthony M. Magliocco,V.S. Kavadi,Yolanda I. Garces,Samir Narayan,Puneeth Iyengar,Cliff G. Robinson,Raymond B. Wynn,Christopher Koprowski,Joanne Meng,Jonathan J. Beitler,Rakesh Gaur,Walter J. Curran,Hak Choy +21 more
TL;DR: Overall survival after standard-dose versus high-dose conformal radiotherapy with concurrent chemotherapy and the addition of cetuximab to concurrent chemoradiation for patients with inoperable stage III non-small-cell lung cancer was compared.
Journal ArticleDOI
Metabolic Dysregulation and Adipose Tissue Fibrosis: Role of Collagen VI†
Tayeba Khan,Eric S. Muise,Puneeth Iyengar,Puneeth Iyengar,Zhao V. Wang,Manisha Chandalia,Nicola Abate,Bei B. Zhang,Paolo Bonaldo,Streamson C. Chua,Philipp E. Scherer +10 more
TL;DR: It is suggested that weakening the extracellular scaffold of adipocytes enables their stress-free expansion during states of positive energy balance, which is consequently associated with an improved inflammatory profile and implicating “adipose tissue fibrosis” as a hallmark of metabolically challenged adipocytes.
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Consolidative Radiotherapy for Limited Metastatic Non-Small-Cell Lung Cancer: A Phase 2 Randomized Clinical Trial.
Puneeth Iyengar,Zabi Wardak,David E. Gerber,Vasu Tumati,Chul Ahn,Randall S. Hughes,Jonathan E. Dowell,Naga Cheedella,Lucien A. Nedzi,Kenneth D. Westover,Suprabha Pulipparacharuvil,Hak Choy,Robert Timmerman +12 more
TL;DR: Consolidative SAbR prior to maintenance chemotherapy appeared beneficial, nearly tripling PFS in patients with limited metastatic NSCLC compared with maintenance chemotherapy alone, with no difference in toxic effects.
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Impact of Intensity-Modulated Radiation Therapy Technique for Locally Advanced Non–Small-Cell Lung Cancer: A Secondary Analysis of the NRG Oncology RTOG 0617 Randomized Clinical Trial
Stephen G. Chun,Chen Hu,Hak Choy,R.U. Komaki,Robert Timmerman,Steven E. Schild,Jeffrey A. Bogart,Michael C. Dobelbower,Walter Bosch,James M. Galvin,V.S. Kavadi,Samir Narayan,Puneeth Iyengar,Clifford G. Robinson,Raymond B. Wynn,Adam Raben,Mark E. Augspurger,Robert MacRae,Rebecca Paulus,Jeffrey D. Bradley +19 more
TL;DR: IMRT was associated with lower rates of severe pneumonitis and cardiac doses in NRG Oncology clinical trial RTOG 0617, which supports routine use of IMRT for locally advanced NSCLC.
Journal ArticleDOI
The Hyperglycemia-induced Inflammatory Response in Adipocytes THE ROLE OF REACTIVE OXYGEN SPECIES
Ying Lin,Anders H. Berg,Puneeth Iyengar,Tony K.T. Lam,Adria Giacca,Terry P. Combs,Michael W. Rajala,Xueliang Du,Brent Rollman,Weijie Li,Meredith Hawkins,Nir Barzilai,Christopher J. Rhodes,I. George Fantus,Michael Brownlee,Philipp E. Scherer +15 more
TL;DR: Analysis of adipocytes exposed to hyperglycemia both in vitro as well as in vivo highlights the importance ROS production in adipocytes and the associated insulin resistance and inflammatory response.