Qingguo Wang

TL;DR: The Cancer Genome Atlas (TCGA) has been used for a comprehensive molecular analysis of primary prostate carcinomas as discussed by the authors, revealing substantial heterogeneity among primary prostate cancers, evident in the spectrum of molecular abnormalities and its variable clinical course.

TL;DR: A comprehensive molecular analysis of 333 primary prostate carcinomas revealed a molecular taxonomy in which 74% of these tumors fell into one of seven subtypes defined by specific gene fusions (ERG, ETV1/4, and FLI1) or mutations (SPOP, FOXA1, and IDH1).

TL;DR: The recent advances in computational methods pertaining to CNV detection using whole genome and whole exome sequencing data are reviewed to discuss their strengths and weaknesses and suggest directions for future development.

TL;DR: Data support a role for the IGF-1R–IRS-1 pathway in both ALK TKI–sensitive and ALKTKI–resistant states and provide a biological rationale for further clinical development of dual ALK and IGF- 1R inhibitors.

TL;DR: It is shown that somatic heterozygous deletion of mouse chromosome 11B3, a 4-megabase region syntenic to human 17p13.1, produces a greater effect on lymphoma and leukaemia development than Trp53 deletion, implying that the selective advantage produced by human chromosome 17p deletion reflects the combined impact of TP53 loss and the reduced dosage of linked tumour suppressor genes.