Rafal Pawlinski

TL;DR: The results indicate that heme promotes tissue factor-dependent coagulation activation and induces tissue factor expression on leukocytes in vivo and that free heme may contribute to thrombin generation in a mouse model of sickle cell disease.

TL;DR: PAR-2 deficiency reduces myocardial infarction and heart remodeling after I/R injury and PAR-2−/− mice were protected from postinfarction remodeling and showed less impairment in heart function compared with wild-type littermates up to 4 weeks after I-R injury.

TL;DR: It is demonstrated that GelE from E. faecalis can regulate enteric epithelial permeability via PAR2, and this protease-mediated disruption of the intestinal epithelium is a potential mechanism whereby a dysbiotic enteric microbiota can lead to disease.

TL;DR: Encouraging clinical data suggest that heparin‐like molecules may represent a useful approach to treat or prevent severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection, and a novel strategy is proposed using “designer” heparIn molecules that are fabricated using a synthetic biology approach.

TL;DR: Results between genetic and pharmacological approaches indicate that further studies are needed to determine the role of different PARs in the injured heart, and it is possible that the major cellular target of the PAR‐4 inhibitor is platelets, which has been shown to contribute to inflammation in thejured heart, whereasPAR‐4 signaling in cardiomyocytes may be protective.