R
Rafal Pawlinski
Researcher at University of North Carolina at Chapel Hill
Publications - 119
Citations - 7414
Rafal Pawlinski is an academic researcher from University of North Carolina at Chapel Hill. The author has contributed to research in topics: Tissue factor & Inflammation. The author has an hindex of 37, co-authored 112 publications receiving 6482 citations. Previous affiliations of Rafal Pawlinski include Scripps Research Institute & Jagiellonian University.
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Journal ArticleDOI
PI3K-Akt Pathway Suppresses Coagulation and Inflammation in Endotoxemic Mice
TL;DR: The data suggest that the PI3K-Akt pathway suppresses LPS-induced inflammation and coagulation in endotoxemic mice.
Journal ArticleDOI
Genetic Analysis of the Role of the PI3K-Akt Pathway in Lipopolysaccharide-Induced Cytokine and Tissue Factor Gene Expression in Monocytes/Macrophages
James P. Luyendyk,Gernot Schabbauer,Michael Tencati,Todd Holscher,Rafal Pawlinski,Nigel Mackman +5 more
TL;DR: The results indicate that the PI3K-Akt pathway negatively regulates LPS signaling and gene expression in monocytes/macrophages and in mice.
Journal ArticleDOI
Morphology of reactive microglia in the injured cerebral cortex. Fractal analysis and complementary quantitative methods.
TL;DR: The present study focuses on application of quantitative methods measuring differences between particular morphological types of microglial cells as well as between their proliferating and non‐proliferating examples, indicating that proliferating microglia were more massive and less‐ramified but they did not reduce their spatial complexity.
Journal ArticleDOI
In vitro activation of coagulation by human neutrophil DNA and histone proteins but not neutrophil extracellular traps.
Denis F. Noubouossie,Matthew F. Whelihan,Yuan Bin Yu,Erica M. Sparkenbaugh,Rafal Pawlinski,Dougald M. Monroe,Nigel S. Key +6 more
TL;DR: It is concluded that unlike DNA or individual histone proteins, human intact NETs do not directly initiate or amplify coagulation in vitro.
Journal ArticleDOI
Tumor-derived tissue factor activates coagulation and enhances thrombosis in a mouse xenograft model of human pancreatic cancer.
Jianguo Wang,Julia E. Geddings,Maria M. Aleman,Jessica C. Cardenas,Pichika Chantrathammachart,Julie C. Williams,Daniel Kirchhofer,Vladimir Y. Bogdanov,Ronald R. Bach,Janusz Rak,Frank C. Church,Alisa S. Wolberg,Rafal Pawlinski,Nigel S. Key,Jen Jen Yeh,Nigel Mackman +15 more
TL;DR: The results of the present study using a xenograft mouse model suggest that tumor TF activates coagulation, whereas TF on circulating MPs may trigger venous thrombosis.