R
Rafal Pawlinski
Researcher at University of North Carolina at Chapel Hill
Publications - 119
Citations - 7414
Rafal Pawlinski is an academic researcher from University of North Carolina at Chapel Hill. The author has contributed to research in topics: Tissue factor & Inflammation. The author has an hindex of 37, co-authored 112 publications receiving 6482 citations. Previous affiliations of Rafal Pawlinski include Scripps Research Institute & Jagiellonian University.
Papers
More filters
Journal ArticleDOI
Homogeneous low-molecular-weight heparins with reversible anticoagulant activity
Yongmei Xu,Chao Cai,Kasemsiri Chandarajoti,Po Hung Hsieh,Lingyun Li,Truong Quang Pham,Erica M. Sparkenbaugh,Juzheng Sheng,Nigel S. Key,Rafal Pawlinski,Edward N. Harris,Robert J. Linhardt,Jian Liu +12 more
TL;DR: The high activity of one defined synthetic LMWH against human factor Xa (FXa) was reversible in vitro and in vivo using protamine, demonstrating that synthetically accessible constructs can have a critical role in the next generation of LMWHs.
Journal ArticleDOI
Hematopoietic and nonhematopoietic cell tissue factor activates the coagulation cascade in endotoxemic mice
Rafal Pawlinski,Jianguo Wang,A. Phillip Owens,Julie C. Williams,Silvio Antoniak,Michael Tencati,Thomas Luther,Jesse W. Rowley,Elizabeth N. Low,Andrew S. Weyrich,Nigel Mackman +10 more
TL;DR: It is demonstrated that in a mouse model of endotoxemia activation of the coagulation cascade is initiated by TF expressed by myeloid cells and an unidentified nonhematopoietic cell type(s).
Journal ArticleDOI
Interplay between coagulation and vascular inflammation in sickle cell disease
TL;DR: The role of vascular inflammation and coagulation activation is summarized, potential mechanisms responsible for activation of coagulations are discussed, and recent data demonstrating the crosstalk between coagulated inflammation and vascular inflammation in sickle cell disease are reviewed.
Journal ArticleDOI
Protease-Activated Receptor-1 Contributes to Cardiac Remodeling and Hypertrophy
Rafal Pawlinski,Michael Tencati,Craig R. Hampton,Tetsuro Shishido,Tara A. Bullard,Liam M. Casey,Patricia Andrade-Gordon,Matthias Kotzsch,Denise J. Spring,Thomas Luther,Jun Ichi Abe,Timothy H. Pohlman,Edward D. Verrier,Burns C. Blaxall,Nigel Mackman +14 more
TL;DR: It is found that PAR-1 deficiency reduced dilation of the left ventricle and reduced impairment of left ventricular function 2 weeks after I/R injury and overexpression ofPAR-1 on cardiomyocytes induced eccentric hypertrophy.
Journal ArticleDOI
Cellular sources of tissue factor in endotoxemia and sepsis.
Rafal Pawlinski,Nigel Mackman +1 more
TL;DR: This review focuses on tissue factor expression by hematopoietic and non-hematopOietic cells and its contribution to the activation of coagulation during endotoxemia and sepsis.