R
Rafal Pawlinski
Researcher at University of North Carolina at Chapel Hill
Publications - 119
Citations - 7414
Rafal Pawlinski is an academic researcher from University of North Carolina at Chapel Hill. The author has contributed to research in topics: Tissue factor & Inflammation. The author has an hindex of 37, co-authored 112 publications receiving 6482 citations. Previous affiliations of Rafal Pawlinski include Scripps Research Institute & Jagiellonian University.
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Journal ArticleDOI
PAR-1 contributes to the innate immune response during viral infection
Silvio Antoniak,A. Phillip Owens,Martin Baunacke,Julie C. Williams,Rebecca D. Lee,Alice Weithauser,Patricia A. Sheridan,Ronny Malz,James P. Luyendyk,Denise Esserman,JoAnn Trejo,Daniel Kirchhofer,Burns C. Blaxall,Rafal Pawlinski,Melinda A. Beck,Ursula Rauch,Nigel Mackman +16 more
TL;DR: The results indicate that the tissue factor/thrombin/PAR-1 pathway enhances IFN-β expression and contributes to the innate immune response during single-stranded RNA viral infection.
Journal ArticleDOI
Levels of microparticle tissue factor activity correlate with coagulation activation in endotoxemic mice
TL;DR: The results suggest that the levels of TF‐positive MPs can be used as a biomarker for evaluating the risk of disseminated intravascular coagulation in endotoxemia.
Journal ArticleDOI
Tissue factor, coagulation proteases, and protease-activated receptors in endotoxemia and sepsis.
Rafal Pawlinski,Nigel Mackman +1 more
TL;DR: Combining hirudin treatment to inhibit thrombin signaling through PAR-1 and PAR-4 with PAR-2 deficiency reduced lipopolysaccharide-induced interleukin-6 expression and increased survival and suggest that activation of multiple PARs by coagulation proteases enhances inflammation during endotoxemia.
Journal ArticleDOI
Tissue factor promotes activation of coagulation and inflammation in a mouse model of sickle cell disease.
Pichika Chantrathammachart,Pichika Chantrathammachart,Nigel Mackman,Erica M. Sparkenbaugh,Jianguo Wang,Leslie V. Parise,Daniel Kirchhofer,Nigel S. Key,Rafal Pawlinski +8 more
TL;DR: It appears that TF contributes to these processes without affecting intravascular hemolysis or anemia, and different cellular sources of TF contribute to activation of coagulation, vascular inflammation, and endothelial cell injury.
Journal ArticleDOI
Tissue factor deficiency causes cardiac fibrosis and left ventricular dysfunction
Rafal Pawlinski,A Fernandes,B Kehrle,Brian Pedersen,Graham Parry,Jonathan Erlich,Robert Pyo,D Gutstein,J Zhang,Francis J. Castellino,E Melis,Peter Carmeliet,G Baretton,Thomas Luther,Martin A. Taubman,Elliot D. Rosen,Nigel Mackman +16 more
TL;DR: It is proposed that TF expression by cardiac myocytes provides a secondary hemostatic barrier to protect the heart from hemorrhage and is caused by hemorrhage from cardiac vessels due to impaired hemostasis.