R
Ralf Wiedemuth
Researcher at Dresden University of Technology
Publications - 12
Citations - 478
Ralf Wiedemuth is an academic researcher from Dresden University of Technology. The author has contributed to research in topics: Aurora B kinase & Survivin. The author has an hindex of 9, co-authored 11 publications receiving 367 citations.
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Journal ArticleDOI
DAP12-Based Activating Chimeric Antigen Receptor for NK Cell Tumor Immunotherapy
Katrin Töpfer,Marc Cartellieri,Susanne Michen,Ralf Wiedemuth,Nadja Müller,Dirk Lindemann,Michael Bachmann,Monika Füssel,Gabriele Schackert,Achim Temme +9 more
TL;DR: It is concluded that NK cells engineered with DAP12-based CARs are a promising tool for adoptive tumor immunotherapy.
Journal ArticleDOI
RNA interference targeting survivin exerts antitumoral effects in vitro and in established glioma xenografts in vivo
Sandy Hendruschk,Ralf Wiedemuth,Achim Aigner,Katrin Töpfer,Marc Cartellieri,Daniel Martin,Matthias Kirsch,Chrysanthy Ikonomidou,Gabriele Schackert,Achim Temme +9 more
TL;DR: It is concluded that survivin is functionally relevant in gliomas and that PEI-mediated exogenous delivery of siRNA targeting Survivin is a promising strategy for glioblastoma therapy.
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Overcoming concealment effects of targeting moieties in the PEG corona: controlled permeable polymersomes decorated with folate-antennae for selective targeting of tumor cells.
Mohamed A. Yassin,Mohamed A. Yassin,Dietmar Appelhans,Ralf Wiedemuth,Petr Formanek,Susanne Boye,Albena Lederer,Achim Temme,Brigitte Voit,Brigitte Voit +9 more
TL;DR: The excellent biocompatibility, controlled permeability, targeted internalization, as well as selective cytotoxicity of such polymersomes set up the basis for properly smart carrier for targeted drug delivery.
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Chromosomal instability induced by increased BIRC5 /Survivin levels affects tumorigenicity of glioma cells
Marina Conde,Susanne Michen,Ralf Wiedemuth,Barbara Klink,Evelin Schröck,Evelin Schröck,Gabriele Schackert,Gabriele Schackert,Achim Temme,Achim Temme +9 more
TL;DR: Overexpression of Survivin levels promote adaptive evolution of tumors through combining induction of genetic heterogeneity with inhibition of apoptosis and indicates a DNA-repair by non-homologous end joining recombination.
Journal ArticleDOI
Survivin safeguards chromosome numbers and protects from aneuploidy independently from p53
Ralf Wiedemuth,Barbara Klink,Katrin Töpfer,Evelin Schröck,Gabriele Schackert,Masaaki Tatsuka,Achim Temme +6 more
TL;DR: It is suggested that Survivin plays an essential role in proper amphitelic kinetochore-spindle assembly and that constraining Survivin’s mitotic function results in polyploidy and aneuploidsy which cannot be controlled by p53.