R
Ram Ajore
Researcher at Lund University
Publications - 22
Citations - 1728
Ram Ajore is an academic researcher from Lund University. The author has contributed to research in topics: Regulation of gene expression & Repressor. The author has an hindex of 10, co-authored 20 publications receiving 1623 citations. Previous affiliations of Ram Ajore include Central Scientific Instruments Organisation.
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Journal ArticleDOI
Variants in ELL2 influencing immunoglobulin levels associate with multiple myeloma
Bhairavi Swaminathan,Guðmar Thorleifsson,Magnus Jöud,Mina Ali,Ellinor Johnsson,Ram Ajore,Patrick Sulem,Britt-Marie Halvarsson,Guðmundur I Eyjólfsson,Vilhelmina Haraldsdottir,Christina M. Hultman,Erik Ingelsson,Sigurður Yngvi Kristinsson,Anna K. Kähler,Stig Lenhoff,Gisli Masson,Ulf-Henrik Mellqvist,Robert Månsson,Sven Nelander,Isleifur Olafsson,Ólöf Sigurðardóttir,Hlif Steingrimsdottir,Annette Juul Vangsted,Ulla Vogel,Anders Waage,Hareth Nahi,Daniel F. Gudbjartsson,Thorunn Rafnar,Ingemar Turesson,Urban Gullberg,Kari Stefansson,Markus Hansson,Unnur Thorsteinsdottir,Björn Nilsson,Björn Nilsson +34 more
TL;DR: A genome-wide association study in the Nordic region identifying a novel MM risk locus at ELL2 that encodes a stoichiometrically limiting component of the super-elongation complex that drives secretory-specific immunoglobulin mRNA production and transcriptional regulation in plasma cells is reported.
Journal ArticleDOI
Identification of sequence variants influencing immunoglobulin levels.
Stefan Jonsson,Gardar Sveinbjornsson,Aitzkoa Lopez de Lapuente Portilla,Bhairavi Swaminathan,Rosina Plomp,Gillian Dekkers,Ram Ajore,Mina Ali,Arthur E. H. Bentlage,Evelina Elmér,Gudmundur I. Eyjolfsson,Sigurjon A. Gudjonsson,Urban Gullberg,Arnaldur Gylfason,Bjarni V. Halldorsson,Markus Hansson,Hilma Holm,Åsa Johansson,Ellinor Johnsson,Aslaug Jonasdottir,Bjorn R. Ludviksson,Asmundur Oddsson,Isleifur Olafsson,Sigurgeir Olafsson,Olof Sigurdardottir,Asgeir Sigurdsson,Lilja Stefansdottir,Gisli Masson,Patrick Sulem,Manfred Wuhrer,Anna-Karin Wihlborg,Gudmar Thorleifsson,Daniel F. Gudbjartsson,Unnur Thorsteinsdottir,Gestur Vidarsson,Ingileif Jonsdottir,Björn Nilsson,Björn Nilsson,Kari Stefansson +38 more
TL;DR: A genome-wide association study of 19,219 individuals found 38 new variants and replicated 5 known variants associating with IgA, IgG or IgM levels or with composite immunoglobulin traits, accounted for by 32 loci.
Journal ArticleDOI
Deletion of ribosomal protein genes is a common vulnerability in human cancer, especially in concert with TP53 mutations
Ram Ajore,David M. Raiser,Marie McConkey,Magnus Jöud,Bernd Boidol,Brenton G. Mar,Gordon Saksena,David M. Weinstock,Scott A. Armstrong,Steven R. Ellis,Benjamin L. Ebert,Benjamin L. Ebert,Björn Nilsson,Björn Nilsson +13 more
TL;DR: In this paper, the authors performed a large-scale analysis of cancer genome data to examine the frequency and selective pressure of RPG lesions across human cancers and found that hemizygous RPG deletions are common, occurring in about 43% of 10,744 cancer specimens and cell lines.
Deletion of ribosomal protein genes is a common vulnerability in human cancer, especially in concert with
Ram Ajore,David M. Raiser,Marie McConkey,Magnus Jöud,Bernd Boidol,Brenton G. Mar,Gordon Saksena,David M. Weinstock,Scott A. Armstrong,Steven R. Ellis,Benjamin L. Ebert,Björn Nilsson +11 more
TL;DR: The results establish RPG haploinsufficiency as a strikingly common vulnerability of human cancers that associates with TP53 mutations and could be targetable therapeutically.
Journal ArticleDOI
The multiple myeloma risk allele at 5q15 lowers ELL2 expression and increases ribosomal gene expression.
Mina Ali,Ram Ajore,Anna-Karin Wihlborg,Abhishek Niroula,Bhairavi Swaminathan,Ellinor Johnsson,Owen W. Stephens,Gareth J. Morgan,Tobias Meissner,Ingemar Turesson,Hartmut Goldschmidt,Ulf-Henrik Mellqvist,Urban Gullberg,Markus Hansson,Kari Hemminki,Kari Hemminki,Hareth Nahi,Anders Waage,Niels Weinhold,Björn Nilsson,Björn Nilsson +20 more
TL;DR: ELL2 was recently discovered as a susceptibility gene for multiple myeloma, and it is shown that the MM risk allele lowers ELL2 expression in plasma cells, that it also upregulates gene sets related to ribosome biogenesis, and that one of the linked variants reduces binding of MAFF/G/K family transcription factors.