B
Bhairavi Swaminathan
Researcher at University of Illinois at Chicago
Publications - 21
Citations - 1892
Bhairavi Swaminathan is an academic researcher from University of Illinois at Chicago. The author has contributed to research in topics: Notch signaling pathway & Biology. The author has an hindex of 11, co-authored 15 publications receiving 1749 citations. Previous affiliations of Bhairavi Swaminathan include University of the Basque Country & Lund University.
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Journal ArticleDOI
Variants in ELL2 influencing immunoglobulin levels associate with multiple myeloma
Bhairavi Swaminathan,Guðmar Thorleifsson,Magnus Jöud,Mina Ali,Ellinor Johnsson,Ram Ajore,Patrick Sulem,Britt-Marie Halvarsson,Guðmundur I Eyjólfsson,Vilhelmina Haraldsdottir,Christina M. Hultman,Erik Ingelsson,Sigurður Yngvi Kristinsson,Anna K. Kähler,Stig Lenhoff,Gisli Masson,Ulf-Henrik Mellqvist,Robert Månsson,Sven Nelander,Isleifur Olafsson,Ólöf Sigurðardóttir,Hlif Steingrimsdottir,Annette Juul Vangsted,Ulla Vogel,Anders Waage,Hareth Nahi,Daniel F. Gudbjartsson,Thorunn Rafnar,Ingemar Turesson,Urban Gullberg,Kari Stefansson,Markus Hansson,Unnur Thorsteinsdottir,Björn Nilsson,Björn Nilsson +34 more
TL;DR: A genome-wide association study in the Nordic region identifying a novel MM risk locus at ELL2 that encodes a stoichiometrically limiting component of the super-elongation complex that drives secretory-specific immunoglobulin mRNA production and transcriptional regulation in plasma cells is reported.
Journal ArticleDOI
Genome-wide association study identifies multiple susceptibility loci for multiple myeloma
Jonathan S. Mitchell,Ni Li,Niels Weinhold,Niels Weinhold,Asta Försti,Asta Försti,Mina Ali,Mark van Duin,Gudmar Thorleifsson,David W. Johnson,Bowang Chen,Britt Marie Halvarsson,Daniel F. Gudbjartsson,Daniel F. Gudbjartsson,Rowan Kuiper,Owen W. Stephens,Uta Bertsch,Peter Broderick,Chiara Campo,Hermann Einsele,W Gregory,Urban Gullberg,Marc Henrion,Jens Hillengass,Per Hoffmann,Per Hoffmann,Graham Jackson,Ellinor Johnsson,Magnus Jöud,Sigurur Y. Kristinsson,Stig Lenhoff,Oleg Lenive,Ulf-Henrik Mellqvist,Gabriele Migliorini,Hareth Nahi,Sven Nelander,Jolanta Nickel,Markus M. Nöthen,Thorunn Rafnar,Fiona M. Ross,Miguel Inacio da Silva Filho,Bhairavi Swaminathan,Hauke Thomsen,Ingemar Turesson,Annette Juul Vangsted,Ulla Vogel,Anders Waage,Brian A Walker,Anna-Karin Wihlborg,Annemiek Broyl,Faith E. Davies,Unnur Thorsteinsdottir,Unnur Thorsteinsdottir,Christian Langer,Markus Hansson,Martin Kaiser,Pieter Sonneveld,Kari Stefansson,Gareth J. Morgan,Hartmut Goldschmidt,Kari Hemminki,Kari Hemminki,Björn Nilsson,Björn Nilsson,Richard S. Houlston +64 more
TL;DR: Eight new loci are discovered at 6p22.3, which localize in or near to JARID2, ATG5, SMARCD3, CCAT1, CDKN2A, WAC, RFWD3 and PREX1, providing additional support for a polygenic model of MM and insight into the biological basis of tumour development.
Journal ArticleDOI
Identification of sequence variants influencing immunoglobulin levels.
Stefan Jonsson,Gardar Sveinbjornsson,Aitzkoa Lopez de Lapuente Portilla,Bhairavi Swaminathan,Rosina Plomp,Gillian Dekkers,Ram Ajore,Mina Ali,Arthur E. H. Bentlage,Evelina Elmér,Gudmundur I. Eyjolfsson,Sigurjon A. Gudjonsson,Urban Gullberg,Arnaldur Gylfason,Bjarni V. Halldorsson,Markus Hansson,Hilma Holm,Åsa Johansson,Ellinor Johnsson,Aslaug Jonasdottir,Bjorn R. Ludviksson,Asmundur Oddsson,Isleifur Olafsson,Sigurgeir Olafsson,Olof Sigurdardottir,Asgeir Sigurdsson,Lilja Stefansdottir,Gisli Masson,Patrick Sulem,Manfred Wuhrer,Anna-Karin Wihlborg,Gudmar Thorleifsson,Daniel F. Gudbjartsson,Unnur Thorsteinsdottir,Gestur Vidarsson,Ingileif Jonsdottir,Björn Nilsson,Björn Nilsson,Kari Stefansson +38 more
TL;DR: A genome-wide association study of 19,219 individuals found 38 new variants and replicated 5 known variants associating with IgA, IgG or IgM levels or with composite immunoglobulin traits, accounted for by 32 loci.
Journal ArticleDOI
A cytokine gene screen uncovers SOCS1 as genetic risk factor for multiple sclerosis
Koen Vandenbroeck,Koen Vandenbroeck,Jorge I. Alvarez,Bhairavi Swaminathan,Iraide Alloza,Fuencisla Matesanz,Elena Urcelay,Manuel Comabella,Antonio Alcina,María Fedetz,Miguel A. Ortiz,Guillermo Izquierdo,Oscar Fernández,Naiara Rodríguez-Ezpeleta,Carlos Matute,Stacy J. Caillier,R. Arroyo,Xavier Montalban,Jorge R. Oksenberg,Alfredo Antigüedad,Ana M. Aransay +20 more
TL;DR: The association with SOCS1 appears independent from the chr16MS risk locus CLEC16A and the T allele of rs243324 was consistently increased in relapsing-remitting/secondary progressive versus primary-progressive MS patients, in each of the six data sets used in this study.
Journal ArticleDOI
Autophagic marker MAP1LC3B expression levels are associated with carotid atherosclerosis symptomatology.
Bhairavi Swaminathan,Haize Goikuria,Reyes Vega,Alfredo Rodríguez-Antigüedad,Antonio López Medina,Maria Del Mar Freijo,Koen Vandenbroeck,Iraide Alloza +7 more
TL;DR: Analysis of differentially expressed genes in stable versus unstable plaques may provide clues toward disclosing the mechanistic basis of plaque instability, and may help to identify prognostic biomarkers for ischaemic events.